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      community Pelage are going to do two phase 3 trials for PP405. How long will it take to complete two phase 3 trials?

      in Chat  45 upvotes 6 months ago
      Pelage plans to conduct two Phase 3 trials for PP405, a new hair loss treatment, which may take about a year to complete. Users discuss various hair loss treatments, including pyrilutamide, minoxidil, finasteride, and clascoterone, with some expressing impatience over the lengthy trial process compared to faster drug approvals like the COVID vaccine.

      community Finasteride doubled my testosterone & estrogen

      in Chat  265 upvotes 7 months ago
      Finasteride increased testosterone and estrogen, stopped hair loss, and promoted regrowth. Users discussed side effects like libido changes and considered adding minoxidil and aromatase inhibitors.

      community Accelerated Hair Loss from Creatine

      in Finasteride/Dutasteride  133 upvotes 8 months ago
      Creatine may cause hair loss in some individuals, especially those on finasteride, despite no scientific link. Personal experiences suggest individual sensitivity to DHT could be a factor.

      community It's always the Mice that gets to grow back hair.

      in Research/Science  431 upvotes 8 months ago
      Sodium dodecyl sulfate, oleic acid, and palmitoleic acid may promote hair growth, but their safety and effectiveness for humans are uncertain. Users consider trying these treatments cautiously, exploring alternatives like ostrich oil and microneedling.

      community The amazing fast pace of PP405.

      in Chat  327 upvotes 8 months ago
      PP405 is a new hair loss treatment advancing quickly in trials, generating excitement and skepticism about its effectiveness and marketing claims. Some see it as a potential alternative to minoxidil and finasteride, but concerns about long-term effects and the need for DHT blockers persist.

      community Lost all my progress bc I went to jail :(

      in Update  67 upvotes 8 months ago
      The user lost hair progress while in jail due to stopping treatments like oral dutasteride, topical applications, and ketoconazole shampoo. They plan to restart their regimen and hope to recover in about 18 months.

      community Fighting Seb Derm + MPB - Winning

      in Progress Pictures  74 upvotes 9 months ago
      The user successfully managed hair regrowth by using a combination of finasteride, dutasteride, minoxidil, and specific shampoos to treat seborrheic dermatitis. They emphasize the importance of maintaining a healthy scalp and are considering food intolerance tests to further address inflammation.

      community Progress after 4 years of Fin?

      in Is this regrowth?  187 upvotes 10 months ago
      The user experienced hair regrowth and thicker hair after using finasteride daily for four years and recently added topical minoxidil. They are considering derma stamping but are cautious about switching to dutasteride due to potential side effects.

      community Boyfriend’s hair transformation in 10 months 🥲

      in Progress Pictures  2281 upvotes 10 months ago
      A boyfriend's hair improved significantly over 10 months using minoxidil, steroid cream, antihistamine cream, and wild growth oil, with a strict cleaning regimen. His partner's dedicated care contributed to the transformation.

      community Use minoxidil & finasteride. It works.

      in Minoxidil  555 upvotes 11 months ago
      Minoxidil and finasteride effectively improve hairlines and reduce balding, though some users report side effects like reduced libido. Consistent use over 1-2 years leads to significant hair regrowth, with some users also using skincare and biotin for added benefits.

      community Switching from Topical to Oral Minoxidil.

      in Minoxidil  397 upvotes 11 months ago
      Switching from topical to oral minoxidil for hair loss, with plans to use it alongside dutasteride. Users report mixed experiences, including increased body hair, potential heart-related side effects, and varying hair regrowth.

      community 6 Months Into Dut Progress Pictures

      in Progress Pictures  100 upvotes 1 year ago
      Switching from finasteride to dutasteride caused significant shedding but minimal side effects. The user plans to continue dutasteride for 12 months despite concerns about hair density.

      community Pelage Announces Positive Results of Phase 2a Trials for PP405

      in Update  300 upvotes 1 year ago
      PP405 shows promise in treating severe hair loss, with 31% of users experiencing over 20% hair density increase in four weeks, faster than minoxidil and finasteride. Some users are skeptical about the results' significance and long-term efficacy.

      community PP405 Phase 2a press release with early results

      in Research/Science  700 upvotes 1 year ago
      PP405 shows promise in hair regrowth, with 31% of participants experiencing over 20% increase in hair density after 8 weeks. Phase 3 trials are expected in 2026, with potential market availability by 2029-2031.

      community minoxidil saved my life (no cap)

      in Chat  137 upvotes 1 year ago
      Oral minoxidil and finasteride effectively improved hair growth and stopped hair loss, with no major side effects. The user switched from topical to oral minoxidil, added finasteride, and later transitioned to dutasteride, experiencing regrowth and thicker hair.

      community Switch from fin to dut and its worse

      in Finasteride/Dutasteride  4 upvotes 1 year ago
      Switching from finasteride to dutasteride can worsen hair loss for some men due to increased testosterone levels. Topical treatments like RU58841 and Pyrilutamide are suggested to counteract these effects, but individual responses vary.

      community Guys, we finally have an alternative to finasteride

      in Research/Science  263 upvotes 1 year ago
      A combination of pyrilutamide, minoxidil, and alfatradiol is proposed as an effective alternative to finasteride for treating mild to moderate hair loss, claiming to stabilize hair loss and improve thickness without finasteride's side effects. Some users are skeptical about the effectiveness and approval of these treatments, while others are interested in trying them due to finasteride's side effects.

      community 1.5 years on fin only (1mg daily)

      in Progress Pictures  293 upvotes 1 year ago
      The conversation discusses hair loss treatment with finasteride, which has shown positive results for the user over 1.5 years. Concerns about using minoxidil due to its toxicity to pets, especially cats, are also highlighted.

      community 7 years on Fin… I’m tired of this

      in Progress Pictures  25 upvotes 1 year ago
      The user has been on finasteride for 7 years and had a hair transplant, but is experiencing hair thinning and itchiness, particularly on one side, leading to concerns about male pattern baldness or other health issues. Despite having a full head of hair, the user is considering shaving it due to mental health struggles and is advised to consult a therapist and consider other treatments like minoxidil or dutasteride.

      community Anyone else super depressed cause of hairloss?

      in Finasteride/Dutasteride  185 upvotes 1 year ago
      A 20-year-old is dealing with hair loss, using finasteride and oral minoxidil, and considering dutasteride. Others suggest treatments like dutasteride, hair transplants, therapy, and lifestyle changes to boost confidence and mental health.

      community Are Derma Rollers Actually Harmful in the Long Run?

      in Microneedling  40 upvotes 1 year ago
      Derma rollers may cause scarring alopecia, leading some to prefer dermastamps or dermapens for microneedling. Combining minoxidil with microneedling is effective, but proper technique and healing time are essential to prevent damage.