RU58841, an anti-androgenic compound, showed early promise for treating alopecia but faced challenges after its patent in 1997. Despite advancing to Phase II trials, safety concerns and financial struggles led Aventis to abandon its development. Proskelia, which later merged into ProStrakan, couldn't prioritize the drug, leading to its eventual stagnation and failure to reach the market.
The conversation discusses the effectiveness of oral minoxidil versus topical minoxidil with tretinoin for hair regrowth, with some users suggesting oral minoxidil might be more effective for non-responders to topical treatments. Concerns about side effects and the role of enzymes in activating minoxidil are also mentioned.
The user experienced hair regrowth using finasteride, oral and topical minoxidil, and RU58841, despite initial shedding. They also transitioned from finasteride to dutasteride and addressed scalp issues with a folliculitis shampoo.
The conversation is about evaluating the ingredients in Davines VOLU shampoo for potential red flags. The user is concerned about which ingredients to avoid despite the shampoo being sulfate-free.
A user shared their 6-month progress using a dermaroller and a homemade shampoo made of rosemary water, aloe vera, and vitamin E for hair loss. They provided a link to photos showing their results.
The user has been using Essengen 6+ (a mix of low-dose topical finasteride and minoxidil) for three months, seeing positive results, especially on the crown area. They also use Nizoral for dandruff and dermaroll weekly.
A user recently started using nanoxidil 5% for hair loss, particularly on the hairline, and is seeking feedback or experiences from others. The conversation focuses on the effectiveness of nanoxidil.
HMI-115 is a new drug developed by Bioinvent and licensed by Bayer, with mixed opinions on its potential effectiveness. Some users are skeptical and prefer proven treatments like Minoxidil, finasteride, and RU58841.
The user has been using oral finasteride, topical minoxidil, and a dermaroller for hair regrowth, noticing most improvement between months 3 and 4. Other users commented on the positive results and shared their own treatment routines.
The conversation discusses hair loss treatments, specifically Breezula, Minoxidil, finasteride, and RU58841. Participants express curiosity about Breezula's safety and its steroidal nature.
Tretinoin is used with minoxidil to enhance hair growth, with some users applying tretinoin before minoxidil to improve results. Some users report success with this combination, while others experience irritation or dryness.
Using a routine of 5% minoxidil, microneedling, and tretinoin for hair loss. The user seeks advice on the ideal weekly schedule for applying these treatments.
The conversation discusses the use of spironolactone, cyproterone acetate, and bicalutamide for hair loss, with concerns about side effects like gynecomastia and depression. Topical spironolactone is considered safe for men and effective when combined with regular treatments.
The conversation is about using a topical spray containing minoxidil, finasteride, and tretinoin for hair regrowth over six months, with positive results and minimal side effects. The user also mentions using biotin and alpecin, and discusses the benefits of topical application over oral forms.
The conversation discusses the potential use of verteporfin for hair loss treatment, with one user mentioning their surgeon's interest in trying it and another noting its research status and clinical use as a YAP inhibitor. Some users debate the market size, availability of generics, and the optimism in the hair loss community regarding new treatments.
Autologous exosome treatment for hair loss is being discussed as an emerging option. Minoxidil, finasteride, and RU58841 are also mentioned as treatments.
The user experienced constipation and gas issues possibly linked to Minoxidil and Dutas use, leading them to stop and later restart Minoxidil without lactose. They recently began using finasteride and are awaiting a SIBO test to understand their gastrointestinal issues.
The user asks about the order and compatibility of using topical minoxidil, stemoxydine, The Ordinary natural moisturizing factors + HA for scalp, RU58841, and Nioxin system 2 leave-in treatment. They seek advice on layering these hair loss treatments.
The conversation discusses using liquid cetirizine as a topical treatment for hair loss. It mentions Minoxidil, finasteride, and RU58841 as other treatments.
Avixis Alfatradiol is a topical 5-alpha reductase inhibitor available in Latin America and Germany, but its effectiveness is questioned. A user reported worsened hair loss after using it and recommended finasteride instead due to its proven effectiveness and lower cost.
The user experienced significant hair regrowth using a combination of oral minoxidil (5mg) and dutasteride (0.5mg) along with monthly mesotherapy injections. Despite the progress, the user plans to proceed with a hair transplant to address a receding hairline that hasn't fully responded to the treatment.
The user cannot handle Minoxidil and is looking for an alternative to dilute topical finasteride. They are considering using Alpecin liquid as a solution.
Verteporfin is being discussed for its potential to regrow hair and heal scars, possibly aiding hair transplants or replacing them. Some users are skeptical about its effectiveness, while others suggest combining it with microneedling for better results.
A user shared a 6-month progress picture showing improvement in hair loss using biotin and minoxidil. They also mentioned dealing with stress, diet issues, and seborrheic dermatitis.
GT20029 showed significant hair growth and safety in phase II trials, with no adverse sexual events. Users are hopeful but concerned about future costs and systemic effects.
A user discusses using latanoprost, a costly treatment that may extend the hair growth phase and improve hair quality, wondering why it's not more popular. They already use a combination of finasteride and minoxidil and plan to incorporate latanoprost into their routine.