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GlossarySelective Serotonin Reuptake Inhibitors

medications that increase serotonin levels to treat depression

Selective Serotonin Reuptake Inhibitors (SSRIs) are a class of medications commonly used to treat depression and anxiety disorders. They work by increasing the levels of serotonin, a neurotransmitter, in the brain by inhibiting its reabsorption (reuptake) into neurons, thereby enhancing mood and emotional stability.

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community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

in Finasteride/Dutasteride 26 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community I really wish I started Propecia sooner

in Finasteride/Dutasteride 29 upvotes 3 years ago

A 27-year-old man's experience with taking Finasteride to treat hair loss and the positive side effects he has experienced, such as improved skin. The user also shared their journey of how they were scared away from taking Finasteride due to fear of possible side effects before eventually deciding to take it.

community Hair loss over a year following depression and taking antidepressants

in Side effects? 200 upvotes 4 months ago

A 33-year-old experienced significant hair loss after a depressive episode and taking paroxetine, possibly due to telogen effluvium or androgenic alopecia. Suggestions included reducing alcohol, considering finasteride and minoxidil, and consulting a doctor about antidepressant side effects.

community My Theory Of Androgenic Alopecia

in Research/Science 20 upvotes 5 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community Is someone like Elon Musk still on fin and min after hair transplant?

in Transplants 3 years ago

Hair loss treatments, specifically finasteride and minoxidil, being used by wealthy individuals to combat their genetic predisposition to baldness. It also discussed other potential treatments such as RU58841 and dutasteride.

community How to keep taking finasteride after getting gynecomastia as a side effect (Full guide and 4 year search complete).

in Finasteride/Dutasteride 52 upvotes 4 years ago

User experienced gynecomastia from finasteride and found a solution using liposomal topical finasteride. This method minimizes side effects and is effective for hair loss treatment.

community EU Shouldn't Ban Fin & Dut: PFS is NOT REAL.

in Research/Science 11 upvotes 1 year ago

Finasteride and Dutasteride do not cause depression or "Post Finasteride Syndrome," with concerns often linked to the nocebo effect and preexisting mental health issues. The EU is unlikely to ban these drugs, but access may become more restricted due to ongoing debates.

community Selection of Minoxidil with Finasteride Topical Solution Products

in Finasteride/Dutasteride 12 upvotes 6 years ago

The conversation lists various topical hair loss treatments combining Minoxidil and Finasteride, ranking them by price and providing details like concentration and availability. The user also mentions personal positive results with a topical Finasteride-only solution.

community Topical Finasteride Selection

in Finasteride/Dutasteride 1 upvotes 1 year ago

A user is seeking advice on choosing the right topical finasteride for hair loss, considering different formats (spray, gel, aqueous solution) and brands (Xyon, Ro, Keeps, Hims Rx Hair Loss Serum, Happy Head Topical Rx Serum). They are also concerned about the optimal strength to minimize side effects while using it with topical minoxidil.

community Looking for a hair transplant? I made a clinic 'Red Flag' list. Need your feedback

in Chat 73 upvotes 1 year ago

Selecting a hair transplant clinic requires avoiding pitfalls like prioritizing quantity over quality and aggressive sales tactics. Ensure the clinic uses experienced surgeons and recommends treatments like minoxidil and finasteride before a transplant.

community Is tazarotene potentially better than tretinoin in combination with topical minoxidil?

in Chat 1 upvotes 6 months ago

Tazarotene may be more effective than tretinoin when combined with topical minoxidil for hair loss due to its selective binding to RAR-beta and gamma, though it can cause irritation. Tazarotene's potency can lead to indirect inflammatory reactions despite potentially causing less irritation than tretinoin.

community We need actual hair loss studies on Epristeride

in Research/Science 6 upvotes 1 year ago

Epristeride is a selective 5 alpha reductase type 2 inhibitor that may reduce scalp DHT similarly to finasteride, with potentially fewer side effects. It is suggested that combining epristeride with finasteride or dutasteride could enhance hair loss treatment effectiveness.

community Pyrilutamide ,the molecule’s true nature

in Research 302 upvotes 1 year ago

Pyrilutamide is a selective AR antagonist with a high binding affinity, making it effective in competing with DHT for androgen receptors. The 1% concentration is more effective than the 0.5%, but the latter may suffice for mild hair loss; the drug is considered a good option for those avoiding 5AR blockers due to side effects.

community Could a reversed SARM designed for the scalp serve as a replacement for oral Dut and Fin?

in Finasteride/Dutasteride 2 upvotes 1 year ago

The conversation discusses the potential of developing a selective oral SARM to target androgen activity in the scalp and skin, as an alternative to oral Dutasteride and Finasteride, which have systemic side effects. It also mentions Clascoterone and RU58841 as topical treatments for hair loss.

community 14 yrs Fighting the Good Fight - A Summary

in Treatment 40 upvotes 5 years ago

A user shared their 14-year experience with hair loss treatments, primarily using finasteride, minoxidil, and Nizoral. They highlighted the effectiveness of finasteride despite some side effects and emphasized the importance of early prevention and the potential for negative selection bias in online reviews.

community Treatment of Finasteride Induced Gynecomastia (Male breast tissue growth)

in Finasteride/Dutasteride 16 upvotes 5 years ago

Finasteride can cause gynecomastia, which may be reversible by stopping the drug and using selective estrogen receptor modulators (SERMs) like tamoxifen. Lifestyle changes such as weight loss and avoiding alcohol can also help, but surgery may be needed if the condition persists.

community Take licorice to lower testosterone?

in Question 1 upvotes 9 years ago

Licorice is not recommended for hair loss as it inhibits hair growth and is a non-selective testosterone inhibitor. Alternatives like spironolactone are suggested for those considering hormonal treatments for hair loss.

community Alternatives/unorthodox hairloss protocols to the big three

in Chat 1 upvotes 3 months ago

The conversation discusses alternative and unorthodox hair loss treatments, including RU58841, nandrolone, and dianabol, as well as theoretical approaches involving high doses of estrogen and selective estrogen receptor modulators. These methods are considered extreme and potentially harmful but are explored for those unable to tolerate traditional 5-alpha reductase inhibitors.

community PP405 - A True Breakthrough or Another Disappointment?

in Research/Science 31 upvotes 10 months ago

PP405 shows potential for hair growth, with 31% of advanced balding men experiencing over 20% increase in hair density in 8 weeks. However, skepticism persists due to selective data presentation and lack of long-term results, with comparisons to treatments like minoxidil and finasteride.

community Why is Kevin Mann (Haircafe) Hated?

in Chat 62 upvotes 3 years ago

Hair loss treatments, including microneedling, minoxidil, finasteride and RU58841; the efficacy of these treatments; criticisms of Kevin Mann's content related to his selective data presentation and biases towards certain treatments; and other topics such as DHT being labeled a "trash hormone" and critiques of other hairloss YouTubers.

community Why are low finasteride doses seen as highly ineffective, when studies show 0.05 mg/day to work?

in Finasteride/Dutasteride 38 upvotes 3 years ago

The efficacy of low doses of finasteride to reduce scalp DHT, and whether studies showing a 61% reduction are reflected in actual results. Replies discussed hair growth as an unintended consequence of minoxidil and finasteride use, as well as self-selective bias, potential side effects, and that studies measure effectiveness by hair count changes rather than DHT inhibition.

community Publication concludes finasteride is a associated with a 60% risk of persistent sexual dysfunction.

in Research/Science 342 upvotes 2 months ago

Finasteride is not linked to a 60% risk of persistent sexual dysfunction; this figure applies only to those already experiencing sexual issues. Most users do not have side effects, and the study's methodology is criticized for selection bias.

community I got two hair transplants in Istanbul, one was good and one was bad, this is what I learned

in Research/Science 213 upvotes 2 weeks ago

A user shared their experience with two hair transplants in Istanbul, highlighting the importance of choosing clinics with a low doctor-to-patient ratio, ISHRS membership, thorough consultations, and reliable aftercare. They emphasized the significance of PRP shots post-procedure and advised careful selection of clinics, especially for crown procedures, due to limited donor area opportunities.

community Choose your topical antiandrogen and tell me why

in Product 6 upvotes 1 year ago

The conversation is about choosing a topical antiandrogen for hair loss, with options including RU58841, CB0301, Pyrolutamide, Alfatradiol, and Fluridil. Users discuss their preferences and reasons for selecting specific treatments.

community How an SSRI seemed to help my hairloss

in Chat 6 upvotes 3 years ago

An SSRI (paroxetine) reduced hair loss and itching for a user with male-pattern baldness, but liver issues forced discontinuation, leading to increased hair loss and anxiety. The user plans to try other anti-anxiety medications, noting stress and anxiety significantly impact hair loss.

community Hair Loss Associated with Escitalopram (anti-depressant). Do SSRIs Affect the Hair Follicle?

in Research/Science 7 upvotes 1 year ago

A 22-year-old male experienced hair loss potentially linked to escitalopram, which stopped after switching to vortioxetine. His depressive symptoms improved with continued treatment.

community Is my current doseage viable? (Trans)

in Transgender 3 upvotes 6 months ago

The user is taking Dutasteride, Finasteride, Estradiol, Spironolactone, and Progesterone for hair regrowth and is considering adding Minoxidil and rosemary oil. They are experiencing some hair regrowth and are consulting a dermatologist to avoid a hair transplant.

community Can Dutasteride really destroy your hairline, or is it broscience?

in Finasteride/Dutasteride 39 upvotes 3 years ago

User asks if Dutasteride can destroy hairline. Replies suggest it works for most people, but some experienced negative effects.

community Serenoa repens (Saw palmetto)

in Chat 1 upvotes 2 months ago

Saw palmetto, a 5-alpha reductase inhibitor, caused unexpected side effects like breast changes and altered semen consistency, which resolved after stopping its use. Concerns about similar side effects with finasteride or dutasteride were expressed, and another user reported low libido and depression from saw palmetto.

community Depression, ADHD meds and Finasteride

in Finasteride/Dutasteride 1 upvotes 1 year ago

Finasteride caused anxiety, depression, and hair shedding for the user, leading them to stop taking it. They are now on Lexapro and Adderall for depression and ADHD, and are considering trying topical Finasteride and Minoxidil.