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    GlossarySMAD4

    protein involved in TGF-beta signaling, affecting cell growth and differentiation

    SMAD4, also known as Mothers against decapentaplegic homolog 4, is a protein that plays a crucial role in the TGF-beta signaling pathway, which is involved in regulating cell growth, differentiation, and apoptosis. Mutations in the SMAD4 gene can lead to various medical conditions, including certain types of cancer and hereditary hemorrhagic telangiectasia.

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      community My Theory Of Androgenic Alopecia

      in Research/Science  20 upvotes 7 months ago
      Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

      community What's your option on complementary treatment

      in Product  3 upvotes 2 years ago
      The conversation discusses complementary treatments for hair loss while using finasteride and minoxidil, including scalp massagers, scrubs, coconut oil, and vitamin supplements. The user seeks opinions on these additional treatments.

      community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

      in Research/Science  58 upvotes 3 months ago
      Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

      community Creatine's effect on Hair Loss and DHT

      in Research/Science  101 upvotes 2 years ago
      A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

      community Should I take creatine if Im on fin?

      in Finasteride/Dutasteride  6 upvotes 11 months ago
      Creatine is unlikely to worsen hair loss for those on finasteride, with no strong scientific evidence linking it to increased hair loss. Many users report no negative effects on hair while using creatine.

      community 4 month is in - 2 pics - fin/min+

      in Progress Pictures  386 upvotes 1 year ago
      The user shared a 4-month update on their hair regrowth journey using finasteride, minoxidil, and microneedling, reporting significant progress and styling ability. They emphasized persistence, shared their regimen details, and addressed side effects like weaker erections and blurry vision, which improved with lifestyle changes.

      community Expectations control for SCUBE3

      in Research/Science  22 upvotes 2 years ago
      SCUBE3, a protein linked to hair growth in moles, was discovered over 25 years ago and is being developed by Amplifica for potential hair loss treatment. Concerns exist about SCUBE3's association with cancer, as it is a protein that promotes cell growth, which could potentially trigger cancer development if used for hair growth therapy.

      community 4 month minoxidil foam + 1MM dermarolling update.

      in Progress Pictures  526 upvotes 5 years ago
      User sshamu's progress pictures of 4 months using minoxidil foam and 1MM dermarolling for hair loss, which resulted in impressive results. There is also discussion about how often to use the treatments, as well as potential side effects of finasteride.

      community RU58841 Permanently Fixed Balding In Unexpected Way.

      in Satire  123 upvotes 7 months ago
      The user humorously describes trying various hair loss treatments, including minoxidil, finasteride, and RU58841, with a satirical twist involving psychedelic experiences and imaginary entities. They mistakenly used LSD instead of RU58841 and plan to continue experimenting with other substances.

      community Pp405 - it has to work. It has to.

      in Research/Science  170 upvotes 3 months ago
      Hair loss treatments, including PP405, minoxidil, finasteride, and RU58841, with hopes for future solutions. Participants discuss the emotional impact of hair loss and consider alternatives like hair transplants or acceptance.

      community Here is some hope. Big 4. A lot of growth. Pics.

       16 upvotes 7 years ago
      The user experienced hair regrowth using finasteride, minoxidil, dermarolling, and a castor oil and peppermint mix after initially having a significant hair loss. They reported no lasting side effects from finasteride and believe dermarolling contributed to their hairline growth.

      community my poetic rendition titled "nor-wood" of the song mad-world.

      in Satire  16 upvotes 2 years ago
      The conversation is a satirical poem about hair loss, mentioning treatments like Minoxidil, RU58841, hair transplants, and derma rolling. The user also shares their personal regimen, which includes Dutasteride, Finasteride, Minoxidil, Alfatradiol, Stemoxydine, Ketoconazole shampoo, Fluridil, and Cetirizine, along with monthly microneedling.

      community Iโ€™m convinced that smile is aimed straight at bald people

      in Satire  131 upvotes 2 months ago
      The conversation humorously discusses hair loss, focusing on the envy of an older man, Massimo Cacciari, who has a full head of hair. Treatments mentioned include finasteride, minoxidil, RU58841, and hair transplants, with some users expressing dissatisfaction with baldness and considering various solutions.

      community progress pic after 4 months fin, min

      in Progress Pictures  4 upvotes 2 years ago
      A 38-year-old man from Poland, balding for 15 years, shared his hair regrowth progress after 4 months of using finasteride (fin), minoxidil (min), micro-needling, and infrared light treatments. He recently switched from finasteride to dutasteride.

      community waiting for hope DIY pp405 guy that will save us๐Ÿ˜ก๐Ÿ˜ก๐Ÿ˜”

      in Satire  38 upvotes 7 months ago
      People are discussing the potential of a new hair loss treatment, pp405, and its approval timeline, comparing it to existing treatments like Minoxidil and finasteride. There is skepticism about its effectiveness and concerns about the time it will take for approval and availability, especially in Europe.

      community 4 months min/fin progress. Hopeful

      in Progress Pictures  270 upvotes 1 year ago
      A 19-year-old reports positive hair regrowth using oral minoxidil and finasteride, with no side effects. The conversation includes advice on consulting a dermatologist and exploring alternative treatments.

      community 4 month update fin + min after hair cut

      in Progress Pictures  198 upvotes 1 year ago
      The conversation is about skepticism regarding hair growth results after 4 months of using finasteride and minoxidil. Many users doubt the authenticity of the progress pictures, suggesting the hair growth is too rapid to be real.

      community 4C hair journey minoxidil and finasteride

      in Progress Pictures  13 upvotes 2 months ago
      The user experienced hair loss and started using minoxidil (5%) and finasteride (0.5 mg daily) with inconsistent application but still saw noticeable improvements by the end of January. They use the liquid form of minoxidil.