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community Before and after PP405 from phase 2a after applying it for just 4 weeks

in Chat 279 upvotes 4 months ago

PP405 shows some hair growth after 4 weeks, but results are debated and expectations should be tempered. Some users compare it to minoxidil or finasteride, questioning its effectiveness and commercialization timeline.

community PP405 mechanism question - looking for discussion

in Treatment 6 upvotes 4 months ago

PP405 may promote short-term hair growth by pushing follicles into the growth phase, but concerns exist about long-term effects due to lack of rest phases. Users discuss various treatments like finasteride, minoxidil, spironolactone, alfatradiol, and investigational drugs like KX-826 and GT20029 for hair maintenance and regrowth.

community Is this a good enough progress?

in Is this regrowth? 54 upvotes 4 months ago

The user has seen significant hair regrowth using topical minoxidil and dutasteride, with better results than finasteride alone. Despite concerns about hairline and temporal peaks, others believe a hair transplant is unnecessary due to the current hair condition.

community If on oral minox, would applying Tretinoin on eyebrows make them grow thicker/faster?

in Minoxidil 1 upvotes 4 months ago

Using tretinoin on eyebrows while on oral minoxidil may not enhance growth, as some users report no difference with additional treatments like microneedling. Tretinoin can stimulate hair growth on its own, but its effectiveness varies.

community Haircafe slams pp405 presentation. Are results really that bad?

in Treatment 65 upvotes 4 months ago

PP405 shows promise in activating dormant hair follicles and increasing hair counts but lacks detailed efficacy data compared to minoxidil and finasteride. Opinions are mixed, with some optimism and skepticism about its effectiveness.

community Handle the itch from Minoxidil?

in Minoxidil 1 upvotes 4 months ago

Minoxidil can cause scalp itchiness, often due to propylene glycol, and users suggest alternatives like foam formulations without PG, using moisturizing oils, or reducing application frequency. Some recommend ketoconazole or zinc pyrithione shampoos to help with inflammation and itchiness.

community How do you guys use minoxidil twice a day?

in Minoxidil 10 upvotes 4 months ago

The conversation discusses challenges and tips for applying liquid topical minoxidil twice a day, with users sharing their experiences and methods for managing greasy hair. Many users apply minoxidil once at night, and some combine it with finasteride for better results.

community One year on dut 5mg daily as a 19-20 yr old , answering any queries

in Finasteride/Dutasteride 10 upvotes 4 months ago

A 19-20-year-old has been using 0.5 mg of dutasteride daily for a year to combat hair loss, avoiding minoxidil due to side effects. They plan to continue this regimen and consider a future hair transplant, experiencing no significant side effects from dutasteride.

community Sooo whats the consensus about pp405 now?

in Chat 75 upvotes 4 months ago

PP405 may help with hair regrowth, especially when combined with minoxidil and finasteride, but its long-term effectiveness is unclear. Phase 3 trials are expected to begin soon, with results in a few years.

community Found a slide summary for PP405

in Research/Science 33 upvotes 4 months ago

PP405 shows promise in stimulating new terminal hair growth by activating dormant follicles, with no systemic adverse effects observed in a short-term trial. However, long-term efficacy remains unproven, and further trials are needed to confirm its potential as a hair loss treatment.

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