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Hair follicle stem cells remain in bald individuals, but progenitor cells do not, raising questions about hair regrowth claims by Pelage. PP405 is discussed as a potential treatment, with skepticism about its effectiveness compared to existing treatments like Minoxidil and Finasteride.

The user had a hair transplant five years ago and started using minoxidil three months ago. Commenters recommend adding finasteride or other DHT blockers to prevent further hair loss and maintain results.

Pelage plans to conduct two Phase 3 trials for PP405, a new hair loss treatment, which may take about a year to complete. Users discuss various hair loss treatments, including pyrilutamide, minoxidil, finasteride, and clascoterone, with some expressing impatience over the lengthy trial process compared to faster drug approvals like the COVID vaccine.

Dutasteride is often preferred over finasteride for hair loss due to its stronger DHT blocking, leading to better hair regrowth for some users. However, it can cause side effects like brain fog, libido changes, and mood issues, prompting some to switch back to finasteride or adjust their dosage.

The user is experiencing hair loss and is using oral treatments including 5mg minoxidil, 1.1mg finasteride, and 1mg biotin daily. They are considering adding dutasteride and possibly a hair system, while others suggest patience and additional treatments like microneedling.

A 35-year-old is seeking advice on hair loss treatments, considering minoxidil, finasteride, and possibly a hair transplant in Turkey. They have previously tried microneedling for a year.

The user shared positive results after one year of using topical minoxidil and finasteride for hair loss, reporting no side effects and fuller hair. They recommend trying topical treatments over oral due to fewer side effects.

A 24-year-old reported new hair growth on temples after 3.5 months of using topical minoxidil without shedding. They plan to add finasteride to maintain progress, as minoxidil alone may not be enough long-term.

Ketoconazole 2% shampoo effectively regrew hair by treating scalp dermatitis and inflammation. The user also used jojoba and oat oil, Aveeno moisturizer, and hyaluronic acid for scalp care.

Clascoterone is being discussed as a promising new hair loss treatment, showing significant improvement in trials. Despite this, skepticism persists about its effectiveness, cost, and side effects, with some users preferring minoxidil and finasteride.

The user experienced significant hair improvement over nine months using a routine of oral finasteride, mixed topical and oral minoxidil, microneedling, and Head & Shoulders shampoo. The user attributes the progress to oral minoxidil and reduced stress during paternity leave.

Finasteride is preferred for its shorter half-life and FDA approval, while dutasteride is seen as more effective but not FDA-approved for hair loss. Many combine these with minoxidil for improved results, though side effects and effectiveness vary.

A 29-year-old is experiencing diffuse hair loss and has been using minoxidil without success. They are now trying a routine with oral minoxidil, topical finasteride, and dermarolling, but are unsure about the effectiveness and legitimacy of the products.

Breezula shows promising hair growth results, with up to 539% increase in hair count compared to placebo, and regulatory submissions are planned in the US and EU. Users are cautiously optimistic, noting the potential for Breezula to replace finasteride by targeting DHT without systemic effects.

The user shares a positive experience with Dutasteride for hair loss, noting increased hair density and minimal side effects after switching from Finasteride. They prefer oral Dutasteride and avoid Minoxidil due to its inconvenience and potential risks.

Finasteride is prescribed at 1mg because it is FDA-approved and proven effective, despite evidence that 0.2mg may similarly reduce DHT. The 1mg dose is more effective for hair growth, and lower doses are less available.

The user has been taking 1 mg of finasteride and 6 drops of minoxidil orally per day for five months, experiencing increased hair shedding but also noticing denser and fuller hair according to friends. Despite the shedding, the user is happy with the progress and has not experienced significant side effects, though they caution against the risks of taking minoxidil orally.

The user is experiencing diffuse thinning and inflammation despite using 2.5mg dutasteride daily, ciclopirox, and ketoconazole shampoos. They are considering treatments like hydroxychloroquine and JAK inhibitors due to suspected scarring alopecia and have faced challenges in obtaining a scalp biopsy.

A user shared their experience with hair loss treatments, switching from 1mg finasteride and topical minoxidil to 5mg oral minoxidil and oral dutasteride, noting improvements despite shedding phases. Other users discussed the hair growth cycle, treatment effects, and shared advice on managing hair loss, including buzzing hair and maintaining mental health.

A user reported significant hair regrowth using a homemade 0.01% topical finasteride solution, highlighting its effectiveness and lack of side effects. The discussion included concerns about oral finasteride's side effects and the benefits of topical solutions.

Matthew McConaughey likely maintains his hair using finasteride, minoxidil, hair transplants, and possibly a hair system. Products like Reginix or rosemary oil are not considered as effective as these treatments.

A 15-year-old is concerned about hair loss, possibly at Norwood 2 or 3, and is using shampoos and conditioners recommended by a trichologist. Suggestions include considering topical minoxidil and consulting a doctor about topical anti-DHT treatments like finasteride or RU58841, but avoiding 5-alpha-reductase inhibitors at this age.

Justin Bieber's hair loss and his choice not to use finasteride or other treatments like rectal injection are discussed, with reasons speculated to be side effects or lack of concern. The conversation also mentions his past hair transplant and suggests his wealth and fame might make appearance less of a priority.

A 19-year-old is using 2.5 mg oral minoxidil for hair loss and plans to add finasteride later, but is concerned about potential hair loss after starting finasteride. Others advise starting finasteride sooner to prevent further hair loss, noting that shedding is a normal part of the process.

Topical finasteride can effectively reduce scalp DHT by targeting local enzymes, despite less systemic impact compared to oral forms. Combining oral dutasteride with topical finasteride and minoxidil may enhance hair loss prevention, though evidence of its effectiveness is limited.

George Clooney likely had a hair transplant, as many Hollywood actors do to maintain their appearance. Treatments like finasteride and hair transplants are common among celebrities to combat hair loss.

A new alcohol-free, propylene glycol-free topical finasteride foam is available for prescription in Canada and the USA, offering a cleaner alternative for hair loss treatment. The product also offers a combination of 0.1% finasteride with 5% minoxidil and aims to be affordable and less irritating for sensitive scalps.

Creating custom topical treatments for hair loss using minoxidil, finasteride, and RU58841. It includes recipes and instructions for home preparation, focusing on cost savings and customization.

A dermatologist advised stopping minoxidil due to heavy shedding, suggesting alternative treatments like Betaval Lotion and supplements, but many users disagreed, recommending continuing minoxidil and adding finasteride for better results. The conversation highlights skepticism about the dermatologist's motives and emphasizes the importance of understanding the type of hair loss before choosing treatments.

Dutasteride is more effective than finasteride for hair loss, with optimal dosing at 0.5mg once or twice a week to minimize side effects. Topical application may further reduce side effects while effectively lowering scalp DHT.