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GlossarySubcision

Subcision is a minimally invasive surgical procedure used to treat various skin conditions, including hair loss, by breaking up fibrous tissue that may be contributing to scarring or tethering of the skin. In the context of hair loss, subcision can help improve blood flow and promote the release of growth factors in the scalp, potentially enhancing hair follicle health and stimulating hair regrowth. Key distinguishing characteristics of subcision include its focus on the underlying connective tissue rather than the surface skin, and its ability to create a more favorable environment for hair follicles to thrive.

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community Cassiopea Announces FDA Submission of New Drug Application for Clascoterone Cream 1%, the First New Mechanism of Action for Acne in Nearly 40 Years

in Technology 30 upvotes 6 years ago

The conversation is about a new acne treatment cream called Clascoterone Cream 1%, which is the first new mechanism of action for acne in nearly 40 years. One person joked about hoping their face will be as clean as their bald head after using the cream.

community Following the recent IPO and the positive Phase 3 clinical data for VDPHL01 (extended-release oral minoxidil), what is the projected timeline for the FDA submission and the subsequent commercial availability on the market?

in Chat 4 upvotes 1 month ago

Veradermics' extended-release oral minoxidil is expected to be commercially available in 2027-2028, while another company, Minx, may release a similar product sooner. VDPHL01 is considered more clinically validated compared to Minx.

community Breezula 6 Month Topline Phase III Results Released

in Research/Science 173 upvotes 6 months ago

Breezula shows promising hair growth results, with up to 539% increase in hair count compared to placebo, and regulatory submissions are planned in the US and EU. Users are cautiously optimistic, noting the potential for Breezula to replace finasteride by targeting DHT without systemic effects.

community Clascoterone phase 3 results are out!

in Treatment 83 upvotes 6 months ago

Clascoterone phase 3 results show promising improvements in hair count, but concerns about high costs and lack of detailed data remain. Users compare it to existing treatments like Minoxidil and Finasteride, expressing skepticism about its accessibility and effectiveness.

community Starting position, 21M (more in description)

in Chat 1 upvotes 1 year ago

A 21-year-old male discusses his starting position with hair loss. He mentions using Minoxidil, finasteride, and RU58841 as treatments.

community What do we currently know about clascoterone?

in Chat 5 upvotes 5 months ago

Clascoterone is seen as a promising topical treatment for hair loss, similar to finasteride but without side effects, though concerns exist about its long-term effectiveness. Other treatments discussed include topical minoxidil, ketoconazole, microneedling, and oral options like dutasteride and minoxidil.

community Why us no one talking about this?

in Treatment 61 upvotes 6 months ago

A new hair loss treatment reportedly shows a 539% improvement in hair count, but skepticism remains due to unclear placebo results and potential minimal actual hair growth. Many users doubt its effectiveness and market viability, citing high costs and lack of visual proof.

community Does DHT Cause Complete Baldness?

in Research/Science 5 upvotes 9 months ago

Hair cloning technology is advancing, with clinical trials for improved methods expected by 2028 and 2029, potentially offering a solution for hair loss if donor follicles remain. Organtech's expansion into other biotech areas may secure funding, but the effectiveness of cloning depends on the availability of androgen-resistant donor follicles.

community End of Year 1 [Fin/Min] SonsUK

in Progress Pictures 503 upvotes 1 year ago

The user shared impressive hair regrowth results after one year using oral finasteride and minoxidil spray, despite skepticism from some about the authenticity of the progress. The user experienced minimal side effects, such as an itchy scalp, and emphasized the importance of consistent use for maintaining results.

community I Found Foreign Particles in my Tretinoin Cream

in Treatment 2 years ago

A user applied tretinoin to their scalp for hair loss and found brown particles in the cream. They are seeking information about these particles.

community Clascoterone (Winlevi) Update for Canada

in Treatment 15 upvotes 3 years ago

Clascoterone cream was submitted for review to Health Canada in August 2022, with hopes of approval within 3-6 months. It may potentially enhance finasteride's effects for hair loss treatment.

community Most promising cures for baldness as of May 2026

in Treatment 56 upvotes 3 weeks ago

PP405 is the most promising future treatment for hair loss, aiming to reactivate dormant hair follicles. Clascoterone 5% is the most promising near-term drug, while current strategies include using finasteride or dutasteride to stabilize hair loss and minoxidil to stimulate growth.

community Breezula Phase III 12-Month Data Released by Cosmo Pharma

in Research/Science 39 upvotes 1 month ago

Clascoterone 5% topical solution is effective and safe for long-term use in treating male pattern hair loss. Cosmo Pharma aims for EU and US approval, with a potential US release in late 2027 or early 2028.

community KX-826 Phase 3 Results Are Out

in Research/Science 113 upvotes 2 months ago

KX-826 shows promising results for hair growth with fewer side effects, offering an alternative to finasteride and minoxidil. Users discuss combining it with minoxidil, dermarolling, and Nizoral for improved results.

community Clascoterone - what we have right now

in Research/Science 23 upvotes 3 months ago

Clascoterone is a topical treatment for androgenetic alopecia, showing modest to moderate hair regrowth, and may be available by 2027-2028. It is considered safer than finasteride, with discussions on its effectiveness compared to RU58841 and pyrilutamide.

community Anyone here have a lot of knowledge on hair follicle stem cells and progenitor cells for PP405?

in Chat 4 upvotes 5 months ago

Hair follicle stem cells remain in bald individuals, but progenitor cells do not, raising questions about hair regrowth claims by Pelage. PP405 is discussed as a potential treatment, with skepticism about its effectiveness compared to existing treatments like Minoxidil and Finasteride.

community Why doesn't phase 3 of PP405 start straight away?

in Chat 14 upvotes 5 months ago

Pelage is delaying the start of phase 3 trials for PP405 to 2026 due to necessary regulatory processes, despite having $120 million in funding. Users discuss the potential of PP405 for hair regrowth, with some expressing skepticism and others hopeful for new treatments like Breezula.

community What’s your views on clascoterone 5% topical solution by cosmo

in Research/Science 24 upvotes 6 months ago

Clascoterone 5% topical solution shows promise for treating male-pattern hair loss by blocking DHT at the follicle without systemic absorption, potentially offering fewer side effects than oral treatments like finasteride. While results are promising, long-term safety and effectiveness need further study, and it may serve as a starting point for developing more effective treatments.

community What the Breezula Phase III results mean & realistic timeline

in Research/Science 60 upvotes 6 months ago

Breezula offers modest hair growth similar to finasteride and is expected to be available by late 2026. It is a safe alternative without hormonal side effects and works well with minoxidil.

community My Hairloss Journey (4 years of treatment, early 20s)

in Progress Pictures 7 upvotes 2 years ago

A user shared their 4-year hair loss journey, starting with finasteride and minoxidil, then adding dutasteride and oral minoxidil, which improved their hair. They are now considering RU58841 and a hair transplant in the future.

community Apostles Creed: On The Third Day, He Rose Again From The Dead. 9 Months Dutasteride 1mg daily and Oral Minoxidil 2.5-5mg daily on Diffuse Unpatterned Alopecia

in Progress Pictures 664 upvotes 2 years ago

The conversation is about a person's positive experience with Dutasteride 1mg and Oral Minoxidil 2.5-5mg daily for Diffuse Unpatterned Alopecia, showing significant hair regrowth after 9 months. They mention a tough initial shedding phase, no side effects after 9 months, and a preference for oral treatments due to convenience and pet safety.

community What ever happened to hairlosshelp.com ??!

in Update 35 upvotes 3 years ago

User began losing hair in 2006, used Avodart and got a hair transplant in 2012. They discuss the decline of hair loss forums and the shift to Reddit, which isn't ideal for long-form discussions.

community Pre Fin Bloodwork To Check Other Potential Issues

in Chat 21 upvotes 4 years ago

A user preparing to start finasteride for hair loss wanted to check for any abnormal bloodwork related to hair loss. They shared their blood test results and learned from another user that their doctor prescribed finasteride without any preliminary tests.

community Clascoterone 12 months phase 3 result out

in Treatment 45 upvotes 2 months ago

Clascoterone is promising for hair loss, showing 24.5% improvement in satisfaction compared to placebo. Users consider it an alternative to finasteride, with concerns about absorption and side effects.

community Haircafe slams pp405 presentation. Are results really that bad?

in Treatment 65 upvotes 2 months ago

PP405 shows promise in activating dormant hair follicles and increasing hair counts but lacks detailed efficacy data compared to minoxidil and finasteride. Opinions are mixed, with some optimism and skepticism about its effectiveness.

community My as soon as my son turns 18:

in Satire 1982 upvotes 3 months ago

Hair loss treatments like finasteride, dutasteride, and minoxidil are discussed, with differing views on when to begin treatment. Some suggest early use, while others warn of hormonal side effects from starting too young.

community Has anyone seen the data on this 539% boost breakthrough?

in Technology 867 upvotes 3 months ago

Topical Clascoterone showed a 539% improvement in hair count compared to placebo, but its effectiveness and safety are debated. Users compared it to minoxidil and finasteride, with mixed opinions on its potential release in 2026 or 2027.

community How long are Pelage going to milk the phase 2a results of PP405?

in Chat 21 upvotes 4 months ago

PP405, a potential hair loss treatment, is facing delays in releasing Phase 2 results, causing frustration among users who compare it to past failed treatments. Despite skepticism, some remain hopeful about PP405's future, while others discuss alternative treatments like Clascoterone and its expected market release.

community Clascoterone 5% Delivers Strong Phase 3 Hair-Growth Results

in Research/Science 369 upvotes 5 months ago

Clascoterone 5% solution shows strong potential for hair growth, offering a new treatment for alopecia with minimal side effects. It blocks androgen receptors locally and may be available by late 2026 or early 2027.

community Currently Trending Twitter Post: Clascoterone Hailed as New Cure

in Research/Science 1895 upvotes 6 months ago

Clascoterone is being discussed as a promising new hair loss treatment, showing significant improvement in trials. Despite this, skepticism persists about its effectiveness, cost, and side effects, with some users preferring minoxidil and finasteride.