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GlossarySubstance P

neuropeptide involved in pain perception and inflammation

Substance P (SP) is a neuropeptide that functions as a neurotransmitter and neuromodulator, playing a key role in pain perception by transmitting pain signals to the central nervous system. It is also involved in inflammatory processes and can influence hair growth by affecting the local immune response and blood flow in the scalp.

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community I'm experiencing significant growth with unknown substance(s). I want to know which one it is.

in Product 8 upvotes 2 years ago

A user from Iran reports hair growth in bald spots after using a domestic tonic containing Anageline, Trichogen, Aminexil, Caffeine, Saw Palmetto, and B vitamins, alongside Finasteride, but without Minoxidil. They prefer the tonic over Minoxidil as it doesn't make their hair greasy or cause hair fall.

community Targeting multiple AGA mechanisms with commonly available substances

4 upvotes 7 years ago

The conversation discusses using a multimodal approach to treat androgenic alopecia, including substances like gamma-linolenic acid, DHA, sulforaphane, melatonin, cetirizine, astaxanthin, fisetin, apigenin, curcumin, limonene, genistein, and berberine. Users also mention using ketoconazole, minoxidil, and low-level laser therapy (LLLT) as part of their hair loss treatment regimens.

community For sublingual minoxidil users and topical minoxidil drinkers : You should STOP spraying topical minoxidil to your mouth NOW. You should consider stopping using a drop of it and mixing it with some other substance too, as you may mess up the dosage

in Minoxidil 183 upvotes 6 months ago

Spraying or drinking topical minoxidil is dangerous and less effective than oral minoxidil. Proper oral minoxidil, like Loniten®, is recommended for safety and effectiveness.

community PP405 Updates Feel Like Breadcrumbs at This Point

in Research/Science 1 upvotes 3 weeks ago

PP405 updates are seen as vague and lacking substance, causing frustration among users. Some users report positive effects from using minoxidil and dutasteride, while others remain skeptical about new treatments.

community The perfect reverse reverse hair-loss nuclear stack for those who feel left out

in Satire 415 upvotes 10 months ago

A satirical discussion on intentionally inducing hair loss using harmful habits and substances like cigarettes, junk food, anabolic steroids, and stress. The conversation humorously suggests extreme measures like chemotherapy and hydrofluoric acid, while also mentioning the ineffectiveness of sulfates and pumpkin seed oil in hair loss prevention.

community Seriously confused about minoxidil's method of action

in Minoxidil 5 upvotes 3 years ago

The conversation discusses confusion about how Minoxidil promotes hair growth compared to other substances like Menthol, which have similar actions. The user mentions personal positive results with peppermint oil extract and is currently trying L-citrulline for its vasodilation effects.

community Minoxidil vs Minoxidil + Tretinoin vs Minoxidil + LCLT

in Minoxidil 10 upvotes 5 years ago

The conversation is about comparing the effectiveness of Minoxidil alone versus Minoxidil combined with other substances like Tretinoin, LCLT, Procapil, Aminexil, and Capixyl for hair growth. One user did not understand the terms used.

community WHITE STUFF COMING OUT OF SCALP

4 upvotes 8 years ago

The conversation discusses hair regrowth after a health condition, with the appearance of white substance on the scalp. Suggestions include it being sebum or White Piedra, with a recommendation to try Nizoral.

community Does anyone think their hair loss is thyroid related?

in Chat 11 upvotes 1 year ago

Hair loss may be linked to thyroid issues, with some individuals noticing changes in hair texture when taking substances affecting the thyroid. Treatments mentioned include a topical mix of finasteride, minoxidil, and tretinoin, along with microneedling.

community Is this true? Is long term taking fin harmful to the liver?

in Chat 127 upvotes 2 years ago

The conversation discusses whether long-term use of finasteride (Fin) is harmful to the liver, with various opinions on side effects and comparisons to other substances. Specific treatments mentioned include finasteride, minoxidil (Min), and RU58841 (RU).

community I got an idea to cure baldness but i need your help

in Satire 94 upvotes 3 years ago

User suggests finding unknown baldness cure by applying random items on scalp and reporting results after 6 months. Various users humorously agree to try different substances, including whale sperm and hydrochloric acid.

community Lasering body hair off boosts scalp hair growth?

in Question 4 upvotes 7 years ago

Lasering off body hair does not boost scalp hair growth, as removing body hair does not redirect hair growth substances to the scalp. The idea that body hair uses up resources needed for scalp hair is incorrect, and treatments like finasteride are suggested for addressing hair loss.

community 2024 vs today. Dutasteride 0.5mg and 5mg oral minoxidil

in Progress Pictures 91 upvotes 2 months ago

The user experienced significant hair regrowth using 0.5mg dutasteride and 5mg oral minoxidil, with fewer side effects compared to finasteride. They noticed improvements in hair thickness and hairline, despite intermittent use of performance-enhancing substances.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 413 upvotes 1 year ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community Should topicals be massaged thoroughly into the scalp ?

in Minoxidil 4 upvotes 1 year ago

Topicals like minoxidil and finasteride should reach the scalp, but excessive massaging can cause hair to fall out. The evaporation felt is likely the carrier substances like alcohol or propylene glycol.

community Does it work? Maneup GHK-Cu hair growth serum

in Treatment 8 upvotes 2 years ago

The conversation is about the effectiveness of Maneup GHK-Cu hair growth serum, a topical treatment for hair loss. The user is considering trying it but is skeptical due to issues others have had with DIY injections of a similar substance.

community Guys hear me out we might have a breakthrough

in Satire 665 upvotes 2 years ago

The conversation is a satirical discussion about unconventional hair loss treatments, including using mold, butter, and other non-traditional substances, with no real evidence of effectiveness. Some users joke about side effects like erectile dysfunction and weight gain.

community This guy claims stem cells fixed his balding

in Is this regrowth? 325 upvotes 2 years ago

A man who claimed to have regrown his hair using stem cell treatment, sparking a debate about its effectiveness and cost. Some users suggested he might be using other treatments or substances, while others shared their own experiences with stem cell therapy for hair loss.

community HMI-115 when will it be available

in Research/Science 15 upvotes 3 years ago

The potential availability of a new hair loss treatment called HMI-115, which has shown promising results in experiments on monkeys but is not yet available to the public. Replies cautioned against using unproven substances from shady labs.

community Effect of melatonin on aromatase expression

in Update 5 upvotes 4 years ago

Melatonin's effect on aromatase expression is unclear, with studies showing both increases and decreases. Hormonal impacts are complex and inconsistent, similar to changing health advice on other substances.

community Is there a way to boost/enhance the effects of minoxidil?

in Minoxidil 8 upvotes 6 years ago

Enhancing minoxidil effects can involve using penetration enhancers like DMSO, urea, or retinol, and methods like dermarolling and adding substances like biotin and L-carnitine tartrate. Some users suggest trying higher concentrations of minoxidil if lower percentages are ineffective.

community Hair follicle neogenesis

7 upvotes 10 years ago

A user plans to experiment with creating new hair follicles using methods like derma rolling, applying lithium chloride, tannic acid, and various other substances including caffeine, ketoconazole, and raspberry ketones. They also consider using anti-inflammatories, immunosuppressants, and DHT inhibitors to potentially improve results.

community RU-58441 Janoshik test result of Made-In-China Supplier

in Product 27 upvotes 6 months ago

A user ordered RU58841 from a Chinese supplier, found it to be less than 99% pure, and plans to try a different seller next time. Concerns were raised about impurities, but the user believes they are likely inactive fillers rather than harmful substances.

community RU58841 Permanently Fixed Balding In Unexpected Way.

in Satire 123 upvotes 7 months ago

The user humorously describes trying various hair loss treatments, including minoxidil, finasteride, and RU58841, with a satirical twist involving psychedelic experiences and imaginary entities. They mistakenly used LSD instead of RU58841 and plan to continue experimenting with other substances.

community RU58841 and impact onmale fertility?

in Chat 2 upvotes 1 year ago

The conversation is about the potential impact of RU58841 on male fertility, specifically regarding sperm concentration, total count, and motility. The user is curious about the likelihood of RU58841 reducing fertility based on its mechanism of action and comparisons to similar substances.

community Minoxidil killed my cat - It was just a few licks - Please be super careful with your pets

in Minoxidil 425 upvotes 3 years ago

In this conversation, people discussed how Minoxidil and Finasteride can be toxic to cats if ingested. It was highlighted that even when being careful with application, there is still a risk of poisoning due to the potential for contact between fur/hair and the substances.

community PSA: You can’t donate blood if you are taking finasteride

in Finasteride/Dutasteride 280 upvotes 7 months ago

Finasteride users cannot donate blood due to potential risks to pregnant women, requiring a one-month cessation before donating. Dutasteride requires a six-month deferral, and topical applications are not restricted.

community [M31] 2+ years progress on Oral Dutasteride and Sublingual Minoxidil

in Progress Pictures 67 upvotes 2 years ago

A user shared their 2+ years progress on Oral Dutasteride and Sublingual Minoxidil for hair loss. Another user asked about the form of Minoxidil used sublingually.

community Fin year 3 results/maintainence

in Progress Pictures 332 upvotes 1 year ago

A user has used finasteride for three years to maintain hair thickness and is considering adding minoxidil for temple recession. They report no side effects and are satisfied, while others discuss minoxidil's pros and cons and share hair treatment experiences.

community Soo.. uhh.. one year... wondering when Dutasteride is going to stop hair loss

in Finasteride/Dutasteride 132 upvotes 3 years ago

User has been on finasteride and switched to Dutasteride 6 months ago, using minoxidil, tretinoin, microneedling, and RU-58841, but still experiencing hair loss. Advice given includes waiting 6-18 months for Dutasteride results and checking if it's definitely MPB.