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    Did you mean Steroid Sulfatase?
    GlossarySteroid Sulfatase

    enzyme that converts sulfated steroids into active forms

    Steroid Sulfatase (STS) is an enzyme that plays a crucial role in the metabolism of steroid hormones by converting sulfated steroid precursors into their active forms. This process is important for the regulation of various physiological functions, including skin health, hair growth, and reproductive processes. Deficiencies or mutations in the STS gene can lead to conditions such as X-linked ichthyosis, which is characterized by dry, scaly skin.

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      community The perfect reverse reverse hair-loss nuclear stack for those who feel left out

      in Satire  415 upvotes 10 months ago
      A satirical discussion on intentionally inducing hair loss using harmful habits and substances like cigarettes, junk food, anabolic steroids, and stress. The conversation humorously suggests extreme measures like chemotherapy and hydrofluoric acid, while also mentioning the ineffectiveness of sulfates and pumpkin seed oil in hair loss prevention.

      community Reducing Scalp Inflammation

      in Treatment  5 upvotes 5 years ago
      The conversation discusses treatments for scalp inflammation, suggesting options like scalp massage, changing shampoos, using aloe vera, Tgel, nizoral shampoo, topical cetirizine, and consulting a dermatologist. Finasteride was mentioned as helpful for reducing inflammation, but with side effects.

      community Minoxidil 5% ONLY 3month progress

      in Progress Pictures  966 upvotes 1 year ago
      A 19-year-old saw significant hair regrowth using 5% minoxidil over three months, with only initial shedding as a side effect. They plan to continue minoxidil and may add finasteride to maintain results.

      community Creatine is the opposite of minoxidil !

      in Research/Science  315 upvotes 7 months ago
      Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

      community 22M Losing hair since 16, nothing helps, scalp always itchy. Just fed up.

      in Treatment  59 upvotes 7 months ago
      A 22-year-old experiencing hair loss and persistent scalp itchiness since age 16 has tried various treatments, including finasteride, ketoconazole shampoo, and dietary changes, with no success. Suggestions include consulting a knowledgeable dermatologist, considering seborrheic dermatitis, and trying different shampoos like Selsun Blue or those with selenium sulfide.

      community Painkillers May Block Minoxidil

      in Research/Science  14 upvotes 1 year ago
      Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

      community Why don’t more people use hair fibers?

      in Product  527 upvotes 7 months ago
      Hair fibers can effectively cover thinning hair when used with minoxidil and hairspray but require daily application and can be inconvenient in certain conditions. Some users prefer treatments like finasteride, dutasteride, microneedling, or wigs due to the maintenance and limitations of hair fibers.

      community Minoxidil seems to not work anymore this sucks

      in Progress Pictures  32 upvotes 2 years ago
      A user reported that Minoxidil, a hair growth treatment, stopped working for them despite initial success. Other users suggested not taking breaks from the treatment, checking for fake products, trying microneedling, using oral Minoxidil, combining Minoxidil with tretinoin, and using finasteride.

      community Why can’t we just do another creatine study?

      in Chat  153 upvotes 1 year ago
      Creatine may worsen hair loss in some, especially with androgenic alopecia, but evidence is mixed. Some users experience no hair loss when using creatine with minoxidil and finasteride, while others notice increased shedding.

      community Homelessess: the solution right in front of our eyes?

      in Satire  142 upvotes 5 months ago
      Homelessness is humorously proposed as a solution to hair loss due to less grooming and stress. Treatments like Minoxidil and Finasteride are discussed, with genetics and lifestyle also considered important factors.

      community 6 Months topical 5% minoxidil twice a day.

      in Progress Pictures  147 upvotes 7 months ago
      The user has been using topical 5% minoxidil for six months with minimal results and is worried about greasy hair and potential side effects of adding finasteride. Others suggest combining minoxidil with finasteride for better results, while discussing potential side effects like erectile dysfunction.

      community What’s the most effective way to beat Serb Derm?

      in Treatment  7 upvotes 1 year ago
      OP struggles with scalp flakes causing hair loss and has tried Selsun Blue, Ketoconazole, and ZPT Shampoo without success. Suggestions include using salicylic acid shampoo, shaving the head, using Nizoral, and combining treatments like Minoxidil and finasteride.

      community Oral Minoxidil and Grapefruit Juice

      in Research/Science  96 upvotes 2 years ago
      The conversation is about the potential dangers of taking oral minoxidil and grapefruit juice together. Some users express concern about dangerous drug interactions, while others argue that grapefruit juice may inhibit the metabolism of finasteride. The conclusion is that grapefruit juice may make finasteride less effective, but it won't affect minoxidil.

      community Why the fu*k do people behave like this?

      in Chat  385 upvotes 3 years ago
      People making comments on others' hair loss, and the different strategies used to deal with it. Treatments mentioned include finasteride and minoxidil.

      community Surprise! Hair loss at 25

       5 upvotes 10 years ago
      A user noticed worsening hair loss and is considering treatments. They plan to use finasteride, Rogaine, and a ketoconazole shampoo, and seek advice on their effectiveness and usage.

      community 6 months on minoxidil shedding again

      in Update  265 upvotes 2 months ago
      A user experienced hair shedding after six months of using topical minoxidil and is considering adding finasteride to their routine. Many suggest that minoxidil alone is insufficient for stopping hair loss and recommend combining it with finasteride or dutasteride for better results.
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