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Pelage is delaying the start of phase 3 trials for PP405 to 2026 due to necessary regulatory processes, despite having $120 million in funding. Users discuss the potential of PP405 for hair regrowth, with some expressing skepticism and others hopeful for new treatments like Breezula.

The user has been using 1mg finasteride daily, minoxidil foam once or twice a day, and Nizoral shampoo 3-4 times weekly for 8 months, noticing some shedding but not much growth. Others suggest patience, microneedling, or additional treatments like dutasteride, PRP, or exosomes for better results.

A 44-year-old man has been using finasteride 1mg daily and minoxidil 5% foam for 19 months to address hair loss, with mixed results and continued shedding. Suggestions include trying oral minoxidil, microneedling, and possibly a hair transplant for better cosmetic density.

A user is starting a hair loss treatment with a 3-in-1 spray containing finasteride, minoxidil, and tretinoin. They are concerned about whether to continue shaving their head and how to determine if hair follicles are dead.

Psoriasis shampoo with salicylic acid can improve scalp health and hair quality better than Nizoral. It helps create a cleaner environment for hair growth, especially when using treatments like finasteride.

The user is using topical finasteride (1MG in 30ML stemoxydine) and experiencing a lack of morning erections after three months. They are questioning whether to discontinue the treatment or if the side effect will resolve if they continue.

Piroctone olamine and ketoconazole are both effective for reducing dandruff and hair shedding, with potential benefits for hair thickness and scalp health. Piroctone olamine may be as effective or better than ketoconazole in certain conditions, yet it is often overlooked.

Pelage Pharmaceuticals raised $120M for their hair loss treatment, PP405, showing strong investor confidence despite limited data. There is skepticism about its efficacy and long-term effects compared to treatments like GT20029.

The user shared their hair loss treatment progress using topical products like exosomes, fluridil, Kx826, and topical dutasteride, avoiding oral finasteride and dutasteride due to side effects. They found exosomes from Creative Biolabs most effective and also used topical probiotics, noting improvements without significant side effects.

User found hair loss stabilization without side effects using a topical solution of 0.008% Finasteride, 2% RU, and Stemoxydine. Other treatments like Eucapil, Fluridil, RU-monotherapy, and Pyrilutamide didn't work for them.

Using Nizoral shampoo intermittently and reassessing scalp condition after each bottle, potentially adding in other tools to target seb derm, and alternating between Pura D'Or and Nizoral for a healthy and clean scalp.

People discuss different methods for applying minoxidil foam to the scalp, with some using their hands, caps, or brushes for better coverage. Concerns about finasteride causing hair shedding are addressed, clarifying that healthy hair should not fall out.

Piroctone Olamine at 1% is recommended for reducing scalp inflammation and encouraging hair growth. The user seeks recommendations for UK shampoos/conditioners containing this ingredient.

Using PRP or Exosome treatments alongside Finasteride/Dutasteride and Minoxidil may not significantly enhance results. Dutasteride and oral Minoxidil are considered more effective options.

The user recommends washing hair twice daily with glycerin soap, using finasteride and minoxidil, avoiding cigarettes and alcohol, and maintaining a diet rich in fruits and vegetables. They claim these methods have significantly improved their hair health over 25 years.

The user shared their positive experience with a hair loss treatment regimen, which includes a diluted version of Hims finasteride spray, Kirkland 5% minoxidil, and weekly dermarolling. The user also mentioned taking hair multivitamins and plans to continue updating on their progress.

The user experienced severe dandruff and hair loss, trying various treatments including oils, vitamins, and minoxidil. They found success by simply dampening their scalp with water twice a day, which improved their hair's appearance and eliminated psoriasis.

A user discussed the "Rootique Duo," a device that turns minoxidil into mist for scalp application, but others suggested cheaper alternatives like an AliExpress applicator. Some users prefer traditional methods like droppers or spray nozzles, especially for longer hair.

Switching from finasteride to dutasteride can cause significant hair shedding if done abruptly. It's recommended to overlap both treatments and gradually taper off finasteride to minimize shedding.

RU58841 treatment for hair loss, comparing premixed solutions to powder form. Users prefer powder for cost-effectiveness and customization.

Dutasteride treatment may decrease sperm concentration, but levels remain above WHO recommendations and recover after discontinuation. The study has limitations, including small sample size and lack of pre-treatment sperm data, and does not assess other fertility factors.

The conversation discusses using high molecular weight hyaluronic acid after microneedling to form a protective barrier, though it's considered expensive and offers marginal improvement. Users share experiences with different microneedling tools like derma rollers, dermastamps, and Dr. Pen, with some opting not to use any products on the scalp.

The conversation discusses whether using 0.1% topical finasteride alongside 0.5 mg oral finasteride is excessive, with suggestions to choose either oral or topical treatment. The user also uses 5% minoxidil and mentions concerns about alcohol-based solutions due to seborrheic dermatitis.

A treatment showed a 20% hair density increase in weeks, with nearly a third of participants experiencing significant results, while questions remain about its long-term efficacy and effectiveness across different scalp areas. There is interest in combining it with finasteride and minoxidil for potentially better outcomes.

A phase 3 trial for Breezula (clascoterone solution) to treat male pattern hair loss has been listed, with 726 participants and a completion date of January 2025. Other treatments mentioned include Aneira Pharma's combination of minoxidil and latanoprost, Triple Hair's combination of minoxidil, latanoprost, and finasteride, and a new microneedling and LLLT device called StimuSIL.

The user has been using finasteride (0.5mg), minoxidil (5% foam), dermarolling, and rosemary oil for 3 months, noticing baby hairs and some shedding. Advice given includes continuing the current treatment, considering additional treatments, and potentially increasing the finasteride dose.

The user diagnosed with DUPA tried treatments like dutasteride, finasteride, RU58841, and minoxidil without success and is considering a hair system. They hope for a future cure, possibly with PP405, and others suggest options like scalp biopsy and SMP.

A user shared their experience with a homemade essential oils shampoo for hair loss after stopping finasteride due to side effects. They reported healthier, shinier hair and new body hair growth but no scalp regrowth yet.

A peptide from Japanese water chestnut fruit may help with hair loss by suppressing DHT's effect on hair follicle cell death, potentially serving as a finasteride alternative. The treatment's effectiveness and safety in humans remain uncertain.

Combining 0.5 mg oral finasteride with topical finasteride and minoxidil during an Enclomiphene cycle may help manage increased DHT levels. Monitoring for side effects is advised.