community Reaching the End
User tried dutasteride, topical finasteride, oral minox, dermawounding, saw palmetto, pumpkin seed oil, and ketacozonole for hair loss. Improvement was temporary, now trying RU58841 and seeking help.
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990-1000 / 1000+ resultscommunity EMA is re-examining Winlevi (clascoterone at lower concentration)
Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.
community Possible topical option for preventing BDNF-related hair loss
The conversation discusses hair loss linked to BDNF-increasing nootropics like Semax and Lions Mane. Suggested topical treatments include capsaicin, beta-glucan, and ginseng to counteract TGF-B activation.
community Pyrilutamide US Phase 2 Trial?
The Phase 2 trial for Pyrilutamide in the US, which started a year after the China trials, and inquiring about any available information on when it will finish. Treatments discussed include Minoxidil, Finasteride, and RU58841.
community Is a topical serum as effective as a topical spray?
The post discusses whether a topical serum with 0.3% finasteride, 6% minoxidil, and essential oils is as effective as a spray with the same concentrations but different ingredients for scalp absorption. The user is seeking advice on which formulation absorbs better into the scalp.
community Why is everyone not directly advised Dutasteride?
Dutasteride is less commonly prescribed for hair loss because it is not FDA-approved for this purpose, unlike finasteride, which is more accessible and preferred due to fewer side effects. Dutasteride may be more effective in reducing DHT but has a longer half-life and potentially more significant side effects.
community We always hear that DUT only lowers scalp DHT by 50% (fin at 40%) but a study within the hair follicle itself shows that DUT nukes DHT to near undetectable levels... so which is it??
Dutasteride significantly reduces DHT levels in hair follicles, potentially more effectively than previously thought. The discussion highlights differences in DHT measurements and the impact on hair loss treatment.
community An Uncontrolled Case Series Using a Botanically Derived, β-Cyclodextrin Inclusion Complex in Two Androgenetic Alopecia-Affected Male Subjects
The conversation discusses a botanically derived treatment for androgenetic alopecia using ingredients like saw palmetto, green tea, and evening primrose, showing impressive results over 270 days. Concerns include the study's uncontrolled nature and potential product motivation, with suggestions to enhance absorption through derma rolling.
community Combine minoxidil, tazarotene, lumigan
Combining minoxidil 5%, tazarotene 0.1% cream, and lumigan for hair loss treatment is discussed. The conversation focuses on the safety and effectiveness of using these treatments together.
community Self-Experiment - Topical Rapamycin or a-KB
A user plans to create a DIY topical treatment for hair loss using Rapamycin, possibly combined with alpha-ketoglutaric acid (a-KG). They discuss the concentration and formulation process for Rapamycin, considering safety and skin penetration, and intend to apply it every other day to the scalp.