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      community Clearing the air on how non-surgical treatments really work

       19 upvotes 6 years ago
      Treatments for hair loss, including finasteride, dutasteride, minoxidil, ketoconazole, microneedling, and low level laser light therapy, which aim to reduce DHT production, increase cell absorption and blood flow, and stimulate epidermal stem cells. It also stresses the importance of patience when using these treatments.

      community Tretinoin can make it worse!!!

      in Chat  7 upvotes 2 years ago
      Tretinoin may enhance minoxidil's effectiveness for those not responding to minoxidil alone, but it could reduce efficacy for some who are already responding to minoxidil. Tretinoin requires careful use, including skin moisturizing and sun protection due to increased sensitivity.

      community Tretinoin .. beneficial or hindrance?

      in Treatment  6 upvotes 4 months ago
      Tretinoin combined with minoxidil may improve hair regrowth, especially in difficult areas like temples, but requires diligent scalp cleaning. Some users suggest oral minoxidil as a more potent and less irritating alternative.

      community the ordinary retinol & minoxidil

      in Minoxidil  13 upvotes 1 year ago
      Using retinol with minoxidil may not be as effective as tretinoin, but retinaldehyde or adapalene could be alternatives. A micro-roller with minoxidil is suggested for better results.

      community How can this be? I'm on a damn MTF regimen and still getting decimated

      in Transgender 1 year ago
      The conversation is about a person using minoxidil, finasteride, estrogen, and bicalutamide to combat hair loss, expressing frustration and desperation over their situation. They are advised against using female hormones and encouraged to focus on finasteride and minoxidil, with suggestions to seek therapy for mental health support.

      community Should i stop the treatment seems like nothing works for me.

      in Progress Pictures  23 upvotes 2 years ago
      The conversation is about someone considering stopping their hair loss treatment, which includes minoxidil, finasteride, ketoconazole, microneedling, and oral minoxidil, due to lack of visible results. Replies suggest continuing treatment, considering a hair transplant, and trying dutasteride.

      community Topical min and dermarolling with seborrheic dermatitis

      in Minoxidil  4 upvotes 1 month ago
      The user is managing hair loss with oral finasteride, recently switching to dutasteride, and topical minoxidil, but faces challenges due to seborrheic dermatitis. They seek advice on effective regrowth methods that don't worsen their condition, with suggestions including various shampoos like Vichy Dercos and ketoconazole.

      community Got a crazy shred again 3 months after starting daily microneedling

      in Microneedling  2 upvotes 5 months ago
      The user experienced hair loss after switching to daily microneedling and stopping tretinoin, while continuing oral finasteride, minoxidil, and other treatments. The consensus suggests daily microneedling is excessive and harmful, recommending less frequent sessions to allow healing.

      community Opinions on the “best” topical out there?

      in Treatment  1 upvotes 4 months ago
      The conversation is about choosing effective hair loss treatments, specifically discussing RU58841, 5% minoxidil, copper peptides, microneedling, finasteride, dutasteride, and Tretinoin. The user seeks advice on the best topical treatments and prefers to use only 1-2 products.

      community From Perfect Hair to This: 2 Years of Chronic TE + Unmasked AGA.

      in Treatment  5 upvotes 1 month ago
      A 25-year-old is experiencing chronic telogen effluvium (TE) and androgenetic alopecia (AGA) after surgery, using finasteride, red light therapy, and supplements, and considering oral minoxidil despite heart concerns. They are unsure whether to start minoxidil before or after an upcoming surgery, which may trigger another hair shed.

      community Anagenic is trying to compound Gt20029

      in Treatment  55 upvotes 3 years ago
      The conversation discusses concerns that Anagenic's version of GT20029 might not be as effective or safe as Kintor's, with comparisons to issues faced by pyrilutamide. The chemical structure of the drug has been published.

      community Minoxidil with Tretinoin together

      in Minoxidil  6 upvotes 10 months ago
      Combining tretinoin with minoxidil may improve absorption by exfoliating the scalp, but results vary. Users suggest starting with low frequency to avoid irritation, and some recommend additional treatments like finasteride or microneedling.

      community 3 months later: topical min/fin + MN is working

      in Update  2 upvotes 1 year ago
      The user is seeing positive results in hair growth using a combination of topical minoxidil, finasteride, microneedling, and keto shampoo. They also use a red light panel for collagen rebuilding and are happy with the progress.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community 5 months topical spiro + minox + micro

      in Progress Pictures  7 upvotes 1 year ago
      A 35-year-old male uses topical minoxidil, spironolactone, and microneedling for hair loss, with spironolactone prescribed based on a DNA test indicating poor response to finasteride and dutasteride. Despite concerns about the test's validity and spironolactone's side effects, he reports stable or improved hair condition and no low testosterone symptoms.

      community (Serious) Updates and discussion, new treatments in development

      in Treatment  7 upvotes 1 year ago
      Finasteride, minoxidil, and derma rolling are currently the best treatments for hair loss. New treatments like TDM-105795, GT20029, PP405, HMI 115, Tsuji, Scube 3, RU, JW0061, Topilutamide, and verteporfin show promise but have uncertain timelines.

      community Is Tretinoin gel useful with Oral Minoxidal?

      in Minoxidil  6 upvotes 1 year ago
      Oral minoxidil and finasteride are the main treatments for hair loss, with microneedling as an additional method. Tretinoin gel is not necessary with oral minoxidil but can be used for skincare.

      community Any Microneedling non-responders figure it out by experimenting?

      in Microneedling  1 upvotes 6 months ago
      The conversation discusses experimenting with microneedling for hair loss, specifically addressing non-responsiveness and the use of topical treatments like dutasteride, minoxidil, and tretinoin. The user seeks advice on effective frequency and depth combinations for better results.

      community Adding topical Min and dermastamping to oral Min/Fin?

      in Treatment  1 upvotes 3 months ago
      The user has been using oral Minoxidil, Finasteride, and Biotin for hair recovery and is considering adding topical Minoxidil and dermastamping to improve results. It is suggested to use micro-needling once a week with a 24-hour gap before applying topical Minoxidil.

      community Lowering DHT vs measured level and topical scalp treatment issues

      in Research/Science  1 upvotes 2 years ago
      The conversation discusses the effects of lowering DHT on hair loss and the importance of monitoring DHT levels during treatment. The user suggests that individual responses to DHT and hair loss treatments vary, and expresses a preference for topical treatments over oral medications due to concerns about systemic DHT reduction.

      community Tretinoin for better Minoxidil response

      in Treatment  11 upvotes 5 years ago
      The conversation is about using tretinoin to improve the response to Minoxidil for hair loss treatment. No specific protocol for tretinoin application is provided.