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      community A concern regarding the upcoming androgen degrader drug GT20029

      in Chat  11 upvotes 1 year ago
      GT20029 is a topical treatment that degrades androgen receptors to prevent hair thinning and loss, potentially offering fewer side effects than systemic treatments like finasteride. Concerns include its impact on hair texture and potential systemic effects, with market availability speculated in 3 to 5 years.

      community Low topical fin + 0.5% pyrilutamide

      in Research/Science  2 upvotes 3 months ago
      Using a combination of low-dose topical finasteride (0.025%) and 0.5% pyrilutamide for hair loss, with a focus on minimizing side effects. The user seeks experiences and results from others who have tried this combination.

      community Any good experiences with Alfatradiol ?

      in Treatment  4 upvotes 6 years ago
      Alfatradiol is discussed as a weak 5ARI and estrogen, not as effective as minoxidil, RU58841, or CB-03-01, but a safe alternative for those who can't use finasteride. Users express frustration over the lack of strong FDA-approved topical antiandrogens for hair loss.

      community Can we get a reality check on PP405?

      in Research/Science  81 upvotes 8 months ago
      PP405 is a promising hair loss treatment that may outperform minoxidil and finasteride by reviving dormant follicles and promoting significant regrowth. Results from ongoing trials are awaited, with a potential market release between 2028-2030.

      community Guys, we finally have an alternative to finasteride

      in Research/Science  263 upvotes 1 year ago
      A combination of pyrilutamide, minoxidil, and alfatradiol is proposed as an effective alternative to finasteride for treating mild to moderate hair loss, claiming to stabilize hair loss and improve thickness without finasteride's side effects. Some users are skeptical about the effectiveness and approval of these treatments, while others are interested in trying them due to finasteride's side effects.

      community Alfatradiol Experience (2 months)

      in Treatment  12 upvotes 5 years ago
      User experienced side effects from oral finasteride and tried topical Alfatradiol for hair loss. Alfatradiol provided maintenance without significant regrowth, and user suggests it as an alternative for those struggling with finasteride side effects.

      community 10 day solo pyrilutamide update

      in Chat  11 upvotes 3 years ago
      The user started using pyrilutamide for hair loss on January 24, applying 1ml daily without other treatments, and after 10 days noticed reduced hair shedding and improved hair quality, with plans to continue for at least 6 months. They experienced chest pain initially, which could be related to starting methylphenidate or pyrilutamide, but the pain has since subsided.

      community This true? Sult1a1 enzyme booster 2025

      in Technology  8 upvotes 1 year ago
      The conversation discusses the potential effectiveness of a Sult1a1 enzyme booster in enhancing the results of minoxidil for hair loss. Users express interest in the booster, hoping it will improve the effectiveness of oral minoxidil, especially for those who struggle with topical application.

      community DUPA / APHK discussion ( Diffuse unpatterned alopecia / Acquired Progressive Hair Kinkering )

      in Treatment  4 upvotes 7 years ago
      The user discusses their experience with diffuse unpatterned alopecia and acquired progressive hair kinkering, noting improvements with treatments including biotin, pantothenic acid, finasteride, ketoconazole, and zinc pyrithione shampoo. They report thicker, healthier hair and improved scalp condition, attributing success mainly to biotin, pantothenic acid, and finasteride.

      community Ky19382 group buy results question

      in Technology  2 upvotes 4 years ago
      The conversation discusses the results of a group buy for Ky19382 related to hair loss treatments. Specific treatments mentioned include Minoxidil, finasteride, and RU58841.

      community Best carrier for pyrilutamide?

      in Update  9 upvotes 3 years ago
      The conversation is about adding a low dose of pyrilutamide to a hair loss treatment regimen. Specific treatments mentioned include Minoxidil, finasteride, and RU58841.

      community Hope Medicine HMI-115 got 28M$ investment

      in Research/Science  59 upvotes 2 years ago
      Hope Medicine received a $28M investment for HMI-115, a monoclonal antibody in phase II trials for treating androgenetic alopecia. Some users are skeptical about its effectiveness, while others find the investment and trial results encouraging.

      community PSA: Get your Vitamin D levels checked!

      in Treatment  115 upvotes 3 years ago
      A user improved their hair health by taking 50,000 IU of vitamin D3 weekly due to a deficiency. Others discussed the potential link between vitamin D and hair growth, with some sharing similar experiences and emphasizing the importance of monitoring vitamin D levels and consulting with doctors.

      community RU/Pyrilutamide access and purchase

      in Product  3 upvotes 5 months ago
      The conversation is about accessing and purchasing RU58841 or Pyrilutamide for hair loss treatment, with mentions of alternatives like Breezula. Users discuss price differences in various countries and suggest websites like rudirect.com for purchasing.

      community Lets do this!!! My current Stack

      in Treatment  4 upvotes 1 year ago
      The conversation discusses a hair loss treatment regimen using Alfatradiol, Pyrilutamide, and Minoxidil. The user shares their current stack of these treatments.

      community 12 months progress. Min Topical Fin Pyri MN

      in Progress Pictures  14 upvotes 1 year ago
      A user shared their 12-month progress using 0.5% Pyrilutamide once daily, 0.025% topical finasteride once daily, 5% Minoxidil twice daily, and microneedling 3 times a week. They reported good progress but noted a slowdown in recent months, hoping for thicker hair soon.

      community AHK-cu peptides experiences and sources to buy

      in Product  5 upvotes 1 year ago
      AHK-cu peptides are discussed for hair growth, with users comparing them to GHK-cu peptides and sharing sources to buy. AHK-cu is noted as more expensive, and users express interest in finding cheaper, reliable vendors.

      community VDPHL01 phase-2/3 results comparison

      in Research/Science  128 upvotes 1 month ago
      The conversation discusses hair loss treatments, focusing on a new slow-release oral minoxidil compared to topical minoxidil and finasteride. The results show that twice-daily dosing of the new treatment is slightly more effective than once-daily, but concerns about cost, side effects, and the accuracy of reported results remain.