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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Alfatradiol 1% study rebuttal.

      in Research/Science  4 upvotes 2 years ago
      Alfatradiol is often discussed at a 1% concentration, but studies typically use 0.025%. Some users report success using it as a topical treatment alongside other hair loss treatments like finasteride.

      community MinoxidilMax just launched a 0.3% tretinoin topical. Would you try?

      in Treatment  14 upvotes 4 years ago
      The conversation discusses a new 0.3% tretinoin topical launched by MinoxidilMax for mixing with other solutions, with some users expressing concern about potential skin irritation compared to lower concentrations. MinoxidilMax has also released other products like topical Dutasteride and RU58841.

      community 9 months progress. Started treatment in Aug 24

      in Progress Pictures  227 upvotes 11 months ago
      The user shared progress pictures showing hair growth after 9 months of using 1 mg oral finasteride, 2.5 mg oral minoxidil (recently increased to 5 mg), and 2% ketoconazole shampoo. Users discussed the effectiveness and side effects of these treatments, with some suggesting alternative methods and cautioning about minoxidil dosage.

      community 1 month progress. Fin+minox+dermarolling+ketoconazole

      in Is this regrowth?  10 upvotes 2 years ago
      After one month of treatment with finasteride, minoxidil, dermarolling, ketoconazole shampoo, hair vitamins, and vitamin D3, the user reports minimal visual progress and increased shedding, but notes stronger body hair and light fuzz on eyebrows. The user is inquiring about potential hair regrowth.

      community Is fin not working for me? Burning sensation

      in Finasteride/Dutasteride  1 upvotes 9 months ago
      The user is experiencing a burning sensation on their scalp despite using finasteride and nizoral for hair loss, and is unsure if they should switch to dutasteride. They have reduced their testosterone dose but the burning persists, and a trichologist suggested it might be telogen effluvium.

      community CRAZY HIGH? 1% Fin 0.3% GHK-CU topical perscription

      in Treatment  2 upvotes 1 month ago
      The conversation discusses concerns about using a high concentration of 1% topical finasteride for hairline balding, with some users suggesting starting with a lower dose. It also mentions the use of GHK-CU peptide and the importance of considering the formulation to avoid excessive absorption.

      community Suggestions?

       5 upvotes 12 years ago
      The user is experiencing chronic folliculitis with scalp sores and is concerned about a receding hairline. They have tried various treatments including antibiotics, Nizoral 2% shampoo, and lifestyle changes, but are seeking further advice.

      community Minoxidil with Tretinoin together

      in Minoxidil  6 upvotes 9 months ago
      Combining tretinoin with minoxidil may improve absorption by exfoliating the scalp, but results vary. Users suggest starting with low frequency to avoid irritation, and some recommend additional treatments like finasteride or microneedling.

      community 1 Year on Fin, 2 months on Min

      in Progress Pictures  31 upvotes 2 years ago
      The user has been using 1mg finasteride daily, 0.05% tretinoin, and 5% topical minoxidil for hair loss. They've seen hairline recession with minoxidil but also new baby hairs, indicating a positive response.

      community Homemade finasteride foam similar to minoxidil foam

      in Product 1 year ago
      A user is seeking advice on creating a homemade finasteride foam similar to over-the-counter Minoxidil foam, due to issues with glycerin and propylene glycol in their current solutions. They are considering using a mixture of ethanol/alcohol and water for the foam.

      community Pyrilutamide cease and desist from Kintor

      in Transplants  12 upvotes 3 years ago
      Considering a hair transplant, using Pyrilutamide, the potential availability of CosmeRNA, and the significance of taking Minoxidil and Finasteride for long-term results.

      community 3 months on Fin/Min oral chewable

      in Progress Pictures  621 upvotes 1 month ago
      The user experienced positive hair regrowth and thicker hair after 12 weeks on 1.25mg Finasteride and 2.5mg Minoxidil chewables, with no side effects. They plan to reassess the need for a hair transplant after seeing further progress.

      community Minoxidl 5% and finasteride 1.25mg daily 11 months

      in Finasteride/Dutasteride  99 upvotes 8 months ago
      The conversation discusses using minoxidil 5% and finasteride 1.25mg daily for hair loss, with the user experiencing monthly shedding and a slight decrease in sex drive as a side effect. The user also mentions using a shampoo with piroctone olamine for seborrheic dermatitis and considers oral minoxidil to reduce scalp irritation.

      community Combining topicals together or use them separately

      in Chat  4 upvotes 7 months ago
      Combining Minoxidil with Finasteride or RU58841 may cause interference, irritation, or reduced absorption. It might be better to apply one topical at a time and wait an hour before applying another.

      community Fin update

      in Finasteride  7 upvotes 9 years ago
      User took 1mg finasteride daily and 2% ketoconazole weekly for 5 months, seeing slight hairline regrowth and no major side effects except temporary dry eyes. They encourage others to try finasteride despite negative stories online.
      1.5 years topical min and fin where do I go from here

      community 1.5 years topical min and fin where do I go from here

      in General  69 upvotes 1 year ago
      The user has been using topical minoxidil and finasteride for 1.5 years, which has thickened existing hair but left some areas thin. They suspect the treatment may be causing dandruff or seborrheic dermatitis and are seeking advice.

      community Ketoconazole shampoo, which one to choose??

      in Ketoconazole  6 upvotes 4 months ago
      Ketoconazole shampoo is recommended at a 2% concentration for hair loss, with advice to leave it in the hair for 2-5 minutes. Users discuss different brands, noting that Nizoral contains artificial dyes, and suggest alternatives without dyes.

      community Experience with only Minoxidil and Nizoral

      in Minoxidil  6 upvotes 6 months ago
      Minoxidil and Nizoral alone are unlikely to stop hair loss effectively, as they do not address the root cause, which is often DHT. Many users suggest incorporating a 5AR inhibitor like finasteride or dutasteride for better results, despite concerns about potential side effects.

      community Alfatradiol Experience (2 months)

      in Treatment  12 upvotes 5 years ago
      User experienced side effects from oral finasteride and tried topical Alfatradiol for hair loss. Alfatradiol provided maintenance without significant regrowth, and user suggests it as an alternative for those struggling with finasteride side effects.