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The conversation is about using micro needling and PTD-DBM for hair loss treatment. The user applies PTD-DBM drops on weekdays and performs micro needling weekly.

A user shared their initial experiences with The Ordinary hair density serum, which contains Redensyl (taxifolin). They observed increased hair volume but also developed pimples, likely due to the serum stimulating sebaceous glands.

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

A 39 year old male who has been balding since 23 and is intolerant to finasteride, using microneedling with Derminator 2 once per week and minoxidil foam twice daily in an effort to increase thickness of vellus hairs on the crown and maintain hairline.

The conversation is about making topical finasteride using stemoxydine as a carrier. The user is considering buying Redken Cerafill Hair Re-Densifying Treatment (Stemoxydine) 90ml for this purpose.

The user has been using 0.5mg Dutasteride daily and topical Minoxidil but is experiencing worsening hair density and is considering switching to Finasteride, increasing the Dutasteride dose, or adding RU58841. They are also considering microneedling and have concerns about the effectiveness of generic Dutasteride compared to branded versions.

Finasteride, Minoxidil, Bioneer CosmeRNA, Technoderma, Kintor, Hope, Breezula, and Follicum treatments showed increases in hair count, with Technoderma showing the highest increase at 24.3 hairs/cm². Amplifica has not yet published results.

HMI-115, a potential treatment for hair loss that can reverse miniaturization and make individual hairs thicker, as evidenced by data from macaques given the treatment and one subject in the phase I trial.

A 22-year-old has been using minoxidil for 2 years and started finasteride a week ago to improve hairline density. They are advised to continue both treatments for potential improvement over time and consider styling or hair concealers for immediate visual changes.

Treatments for hair loss, such as minoxidil and finasteride; scalp micropigmentation; and humorous approaches to accepting baldness.

The user experienced reduced hair loss using an online serum but found it too expensive and is seeking a vendor for ptd-dbm. They are also interested in KY19382 but are unable to find it.

A user shared their positive experience with MoriTint, a Korean scalp micro pigmentation technique that enhances the appearance of hair density without being permanent. They now offer this service in Los Angeles and emphasize its benefits for those with thinning hair, while clarifying it is not suitable for those with significant hair loss or baldness.

The user has been using minoxidil and finasteride for 3.5 months and has seen a 20% improvement in hair density. They are advised to continue treatment and consider switching agents or adjusting dosages if needed.

An 18-year-old using finasteride since February and minoxidil since July has not seen improvement in hair density. They are advised to continue treatment as results can take up to a year, and to consider other options if no change occurs after a full year.

A dermatologist recommended a new supplement containing annurca apple, which reportedly doubles hair density and increases keratin after 60 days, to be used with finasteride. Some users are skeptical, considering it potentially ineffective or a marketing ploy, while others are open to trying it if it proves effective and affordable.

TDM-105795 is a potential hair growth stimulant that works differently from minoxidil and could be used alongside it for enhanced growth. It completed phase 2 trials in 2024, with a medium to high chance of release in 2026, but lacks recent updates or phase 3 trial information.

A user experienced increased hair density loss after 4 months on dutasteride combined with finasteride. They are also using topical dutasteride with azelaic acid and alfatradiol but cannot tolerate antiandrogens like RU58841 due to headaches.

Low ferritin levels can affect hair density, and increasing ferritin through iron supplements may help with regrowth. It's suggested to maintain ferritin levels between 70-100 ng/mL and check other micronutrients for optimal hair health.

A 28-year-old male is experiencing temple regrowth but crown thinning while using 5mg minoxidil and 0.5mg dutasteride. The shedding phase is seen as a positive sign of treatment effectiveness, with expectations of noticeable improvements around 6 to 12 months.

Finasteride has been effective for maintaining hair density, but due to a slight dip in temple hair, the user switched to dutasteride as an additional measure. Users discuss varying experiences with side effects from finasteride, dutasteride, and minoxidil, highlighting that reactions can differ significantly among individuals.

Dutasteride improved hair density and thickness in men who didn't respond to finasteride, with some experiencing transient sexual dysfunction. Users discussed switching from finasteride to dutasteride, noting initial shedding but eventual hair improvement.

Shiseido's Dermal Sheath Cup (DSC) Hair Multiplication treatment is now available in Japan. Users discuss the treatment's availability and cost.

The conversation discusses using high molecular weight hyaluronic acid after microneedling to form a protective barrier, though it's considered expensive and offers marginal improvement. Users share experiences with different microneedling tools like derma rollers, dermastamps, and Dr. Pen, with some opting not to use any products on the scalp.

Concerns about metal particles from dermapen or dermaroller needles potentially entering the skin and lymph nodes, similar to tattoo needles. Discussion includes the possibility of using Minoxidil, finasteride, and RU58841 for hair loss treatment.

The user is considering using "Grow Gorgeous Intense Hair Density Serum" alongside Minoxidil and is currently taking Finasteride. Some users doubt the serum's effectiveness, while others suggest it may help with hair strength and thickness, but opinions are mixed.

A 22-year-old with 4c hair is considering a hair transplant to address traction alopecia caused by braid extensions. They have tried derma stamping, oils, and minoxidil but stopped due to side effects.

Maintaining good hair density is more important than preventing a receding hairline, as it can enhance a mature look. Treatments discussed include finasteride, minoxidil, dutasteride, and RU58841.

The user is concerned about the lack of improvement in hair density 12 months after a hair transplant on the crown, despite using minoxidil. The doctor suggests the native hair is thinning, but the user disagrees.

PTD-DBM therapy for hair loss is being developed by Dr. Kang-Yell Choi, with human testing planned in South Korea. Some clinics in the U.S. offer PTD-DBM/valproic acid therapy, but it hasn't completed trials yet.

This post and conversation are about the molecular mechanisms triggered by microneedling, specifically its effects on inflammation, tissue remodeling, epithelial proliferation, differentiation, and collagen synthesis. The discussion highlights the potential benefits of microneedling for hair loss treatment.