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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Electrical devices like violet ray for hair regrowth

      in Technology  5 upvotes 2 years ago
      The conversation discusses using a violet ray device for hair regrowth, citing a case where zinc ion treatments showed promising results. It also mentions similar devices like the Growcombr and niostem helmet.

      community Has anyone tried Topical oxytocin?

      in Treatment 2 years ago
      A user reported less hair shedding using melatonin spray and is considering trying topical oxytocin or estrogel for hair growth, but is concerned about potential side effects like breast development. Topical oxytocin has been found to promote hair growth by increasing growth factors.

      community Roughly 3 years Finateride monotherapy. 25M

      in Progress Pictures  79 upvotes 9 months ago
      A 25-year-old male has been using finasteride since October 2022 to combat diffuse thinning and hairline recession, experiencing initial shedding but later stabilization. He plans to add oral minoxidil to improve hair density and is open to trying dutasteride if necessary, with minimal side effects reported.

      community 4 month Min+Fin progress (topical)

      in Progress Pictures  124 upvotes 2 years ago
      A user shared their 4-month progress using a topical solution with 5% minoxidil and 0.1% finasteride, applied twice daily. They reported good results despite occasional missed applications.

      community Budget LLLT Options: Are the under $200 products legit?

      in Technology  8 upvotes 9 months ago
      The conversation discusses hair loss treatments, specifically the effectiveness and legitimacy of low-level laser therapy (LLLT) devices under $200. The user has seen positive results with finasteride, minoxidil, ketoconazole, microneedling, and scalp massages, and seeks advice on affordable LLLT options.

      community For those thar had a hair transplant.....

      in Is this regrowth?  2 upvotes 2 years ago
      The user had a hair transplant 10 months ago and sees some improvement but still has thin spots. They previously used finasteride pills and now use a topical solution of minoxidil, dutasteride, and tretinoin.

      community Zix + Topical Fin : Blood Test Before/After, AMA and suggestions

      in Treatment  49 upvotes 5 years ago
      A user's plan to use Zix and topical finasteride (5AR inhibitors) for hair loss, followed by blood testing before/after. The user has suggested creating a fund to cover part of the cost of their blood tests. Replies to their post discuss the effectiveness of the treatments.

      community Product search: minox + finast + tret

      in Product  4 upvotes 2 years ago
      The conversation is about someone looking for a single product that combines finasteride, minoxidil, and tretinoin for hair loss treatment. They are asking if it exists, where to find it, and if it's available without a prescription.

      community Tretinoin & Minoxidil application

      in Chat  6 upvotes 2 years ago
      Using Tretinoin with Minoxidil may increase Minoxidil's absorption and improve hair growth results. The user is seeking advice on how to apply both treatments effectively.

      community 5 weeks tretinoin, severe shed and thinning.

      in Minoxidil  3 upvotes 4 months ago
      The user has been using minoxidil for 5 years and finasteride for 7 months, with recent addition of tretinoin cream causing significant hair shedding. Other users suggest the shedding indicates effectiveness and recommend continuing tretinoin use.

      community Before and after of 20 months of fin and min

      in Progress Pictures  125 upvotes 4 months ago
      The user experienced worsening hair thinning despite using finasteride, minoxidil, and ketoconazole shampoo, and switched to dutasteride five months ago. They are considering adding tretinoin and microneedling to their routine for better results.

      community Guys, are any of you using alfatradiol as part of your regimen?

      in Treatment  5 upvotes 2 years ago
      The conversation is about the effectiveness of alfatradiol for hair loss and whether it can be used with or as a replacement for common treatments like minoxidil, finasteride, and RU58841. The user is seeking feedback on others' experiences with alfatradiol.

      community 5 Months Hair Transplant Progress / 3500 Grafts

      in Transplants  1667 upvotes 2 years ago
      A user shared their positive experience with a hair transplant of 3500 grafts, showing significant improvement in appearance after 5 months. They underwent the procedure at Heva Clinic in Istanbul for $2,300 USD, which included aftercare, and attributed their hair loss to both genetics and traction alopecia from tight hairstyles.

      community Actually Life CHANGING | Fin/Min/Tret

      in Progress Pictures  47 upvotes 2 years ago
      The user reports significant hair growth after using finasteride for a year and minoxidil for 2-3 months, along with topical tretinoin. They advise against listening to family or internet fear-mongering about hair loss treatments and encourage using finasteride and minoxidil despite potential side effects.