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960-990 / 1000+ resultscommunity Minoxidil’s mechanism of action on blood pressure as a potassium channel opening molecule
Minoxidil works by opening potassium channels, leading to reduced blood pressure and potential side effects like reflex tachycardia. It is used for hair growth and affects blood pressure at high doses.
community Pyrilutamide phase 3 results and maintenance?
Pyrilutamide phase 3 results showed little to no significant hair regrowth, but may be sufficient for maintaining current hair density. The user is unsure due to lack of recent discussions on pyrilutamide.
community Can retinol add hair regrowth when combined with micro needling/topical minoxidil
community Published in Nature: Osteopontin, a protein involved in the growth of hair on moles could be the key to our troubles.
Osteopontin, a protein involved in hair growth on moles, may help with hair loss. However, it is also linked to Alzheimer's, cancer, and bone development, so caution is advised.
community Has anybody here become a responder once switching from topical minoxidil to topical minoxidil + tretinoin?
Some people saw improved hair growth when adding tretinoin to their topical minoxidil routine. They combined the two by applying tretinoin before minoxidil.
community Tretinoin .. beneficial or hindrance?
Tretinoin combined with minoxidil may improve hair regrowth, especially in difficult areas like temples, but requires diligent scalp cleaning. Some users suggest oral minoxidil as a more potent and less irritating alternative.
community Topical peppermint may reduce scalp T and DHT?
Peppermint oil may promote hair regrowth by decreasing scalp testosterone and DHT levels. Other herbs in the Mint family, like spearmint and rosemary, might also reduce testosterone.
community Stemoxydin and hair cycle question
The user has been using Finasteride for hair loss and is considering adding alphatradiol, stemoxydine, or 2% minoxidil to their regimen. They are concerned that stemoxydine, which shortens the resting phase of hair, might accelerate hair loss in those not using Finasteride by depleting hair cycles without strengthening miniaturized hairs.
community A preliminary study on topical cetirizine in the therapeutic management of androgenetic alopecia.
The conversation discusses using topical cetirizine as a treatment for androgenetic alopecia (hair loss). Specific treatments mentioned include Minoxidil, finasteride, and RU58841.
community PP405 Might Be the Closest We Have to a Upcoming Cure
PP405 is considered a promising potential cure for hair loss, with phase 2 trial results expected in February 2025. Hair cloning is also discussed as a potential ultimate solution, despite significant scientific challenges.
community RU58841 pre-mixed solution loses efficacy after 2 weeks of usage
community Pelage PP405 Phase 2a completed.
Minoxidil, finasteride, and RU58841 are discussed as treatments for hair loss, with excitement around a new drug, PP405, and a reformulated oral minoxidil in trials. Concerns about cost, side effects, and long-term use are also mentioned.
community Mucuna pruriens, dopamine and prolactin. Natural route with oils.
The post discusses using Mucuna pruriens, essential oils, and dermarolling for hair loss treatment. The user also mentions pausing testosterone-boosting herbs due to side effects like acne and hair loss.
community My two months experience with RU58841
community DHT itch and sugar intake ! Anybody seen a link ?
Reducing sugar intake may lessen scalp itchiness associated with hair loss, even when using treatments like finasteride. Some users also report similar symptoms while on dutasteride.
community Hormone Management Advice - Aromatase Inhibitors , SHBG Blockers
The user plans to switch from minoxidil to finasteride or dutasteride for hair loss, while managing hormones with aromatase inhibitors and SHBG blockers. They seek advice on the best options for these treatments, considering past side effects and future therapies.
community How come topical finasteride even works at all?
Topical finasteride can effectively reduce scalp DHT by targeting local enzymes, despite less systemic impact compared to oral forms. Combining oral dutasteride with topical finasteride and minoxidil may enhance hair loss prevention, though evidence of its effectiveness is limited.
community Won’t pp405 and gt20029 be patented and be almost unreasonably expensive
Concerns about the potential high cost of new hair loss treatments, pp405 and gt20029, were discussed, with some users willing to pay a premium if they are effective. Alternatives like finasteride and minoxidil are mentioned as current, more affordable options, and there is speculation about future generic versions and black market availability.
community DHT Gel (2.5%) to beard area + Dut + Pyri 1% + Minox
The conversation discusses using a combination of DHT gel, dutasteride, pyrilutamide, and minoxidil to promote beard growth while minimizing hair loss. Users suggest consulting a doctor and considering genetic factors before proceeding.
community Latanoprost shed - anyone have experience?
The user started using topical latanoprost and dutasteride, experiencing significant hair shedding and scalp itchiness, possibly due to an allergic reaction. They are considering stopping the treatment if the shedding is linked to an allergy.
community We need more people trying 2.5 mg dutasteride
Increasing the dutasteride dose to 2.5 mg may significantly reduce DHT and promote hair regrowth, with similar side effects to lower doses. Some users combine dutasteride with minoxidil and finasteride for better results, but there are concerns about long-term effectiveness and availability.
community Just FYI, Here are pictures of 6 months results on Clascoterone 5%. Is it remarkable? No. But it seems likely to be FDA approved considering 1% is already available. This is a win, especially if you pair it with other treatments like Finasteride.
Clascoterone 5% shows potential for hair thickening and darkening, especially when combined with treatments like finasteride. It may be a good alternative for those who experience side effects from other treatments.
community Bloodwork Results. DHT and Testosterone Levels
The user shared their bloodwork results showing DHT at 17 ng/dl and testosterone at 287 ng/dl, with a slight Vitamin D deficiency. They are seeking opinions on these levels and have an upcoming dermatologist appointment.
community Anybody heard about clascoterone against hair loss?
Clascoterone, an acne treatment that blocks DHT, is being developed for scalp use against hair loss. The conversation also mentions Minoxidil, finasteride, and RU58841 as treatments.
community Han Bio claims success at Hair Multiplication
Han Bio claims success in hair multiplication using dermal papilla cells. Treatments discussed include Minoxidil, finasteride, and RU58841.
community Would appreciate some thoughts on the “dht itch”
The user is experiencing scalp itching despite using finasteride and Ketoconazole shampoo for hair loss and seborrheic dermatitis. They are unsure if the itch is due to their treatments, diet, or mental factors.
community Hair started thinning and found out i have high cortisol and thyroid issues
User experienced hair thinning due to high cortisol and thyroid issues, along with insulin resistance. They are taking magnesium, zinc, vitamin D, calcium, and selenium as supplements.
community Are You Hopeful About VDPHL01?
community Melatonin a possible tool to help fight AGA hair loss.
Topical melatonin may help reduce hair loss and increase hair thickness in people with androgenetic alopecia (AGA), with some studies showing positive results. It can be mixed with minoxidil for application, and its effectiveness might be enhanced when used with micro-needling, but results may vary among individuals.