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GlossaryThalidomide

medication causing birth defects, now used for specific conditions

Thalidomide is a medication that was originally developed in the late 1950s as a sedative and treatment for morning sickness in pregnant women. However, it was later found to cause severe birth defects, leading to its withdrawal from the market. Today, thalidomide is used under strict regulations to treat certain conditions like multiple myeloma and complications of leprosy, due to its anti-inflammatory and immunomodulatory properties.

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community Taiwan scientists used naturally derived fatty acids serum to regrow hairs (in mice <.<)

in Research/Science 96 upvotes 7 months ago

A serum with oleic and palmitoleic acids shows promise for hair regrowth in mice, but its effectiveness in humans is unproven. Minoxidil and finasteride remain the recommended treatments.

community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

in Research/Science 66 upvotes 8 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community Pyrilutamide vs enzalutamide. Same thing?( Especially for biochemists, farmacologists)

in Research/Science 17 upvotes 3 years ago

Researching whether pyri and enza, which are stereoisomers of each other, share the same features related to CNS penetration/GABA Inhibition; safety and efficacy when used topically at 0.5-1%; and cost comparison between the two treatments.

community Kintor’s KX-826 Pyrilutamide!!

in Research/Science 154 upvotes 4 years ago

KX-826 hair loss treatment completed trials with mild side effects. GT20029 may be ultimate cure, destroying androgen receptors causing baldness.

community No, Finasteride as a treatment for MPB was not an "accident"

in Research/Science 108 upvotes 5 years ago

Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.

community Conceived on low dose topical fin (.025%), anyone else?

in Finasteride/Dutasteride 6 upvotes 3 months ago

A user expressed concern about using low-dose topical finasteride while conceiving, but was reassured that the risk of affecting a fetus is negligible. The user stopped using finasteride during pregnancy and switched to minoxidil and ketoconazole, while others shared experiences and advice on using these treatments safely.

community Anagenic is trying to compound Gt20029

in Treatment 56 upvotes 3 years ago

The conversation discusses concerns that Anagenic's version of GT20029 might not be as effective or safe as Kintor's, with comparisons to issues faced by pyrilutamide. The chemical structure of the drug has been published.

community Trestolone (MENT) as a nuclear treatment

in Treatment 99 upvotes 3 years ago

Experimenting with trestolone as a treatment for hair loss in an attempt to avoid DHT-related treatments such as finasteride and dutasteride, and discussing the potential effects of its receptor selectivity on the androgen receptors in the scalp.

community Pregnancy Ru58841. Girlfriend unintentionally impregnated

in Research/Science 6 upvotes 1 year ago

A user stopped using RU58841 after discovering their girlfriend's unplanned pregnancy, expressing concern about potential harm to the baby. Others advised consulting a doctor, waiting for health scans, and considering switching to oral finasteride or natural supplements like saw palmetto.

community GT20029. Kintor Pharma’s Product

in Research/Science 12 upvotes 3 years ago

The conversation discusses GT20029, a compound by Kintor Pharma that degrades androgen receptors and is in trials, with potential as a hair loss cure. Another promising treatment mentioned is an antibody that blocks prolactin and has shown positive results in macaques.

community Heads up for guys with pregnant wives.

in Finasteride/Dutasteride 3 upvotes 2 months ago

Finasteride and dutasteride are not considered safe during pregnancy, with some users suggesting caution and others sharing personal experiences of no issues. The general consensus is to avoid these medications during pregnancy to prevent any potential risks.

community Alfatradiol and bad side effects

in Product 2 upvotes 1 year ago

Using alfatradiol can cause nausea and headaches. Users discuss these side effects and seek advice.

community So Pyrilutamide has been postponed by one year. How likely is that to happen to GT20029

in Treatment 27 upvotes 2 years ago

The conversation discusses the delay in the release of a new hair loss treatment, Pyrilutamide, and speculates on potential safety concerns as a reason for the delay. It also mentions GT20029 as another future treatment option, with a release at least five years away, and touches on the avoidance of research chemicals due to uncertainty about their authenticity.

community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 39 upvotes 3 years ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

community Any further update on kintor pyrilumatide treatment

in Research/Science 26 upvotes 3 years ago

Kintor Pyrilutamide treatment, a potential hair loss treatment that may become available to the public soon. People have been experimenting with using it in topical form, with mixed results and no reported side effects.

community Where the fuck are the pyrilutamide GB guys?

in Chat 23 upvotes 4 years ago

The effects of Pyrilutamide, a hair loss treatment that is being tested for June/July; and reports from people who have experienced side effects similar to those of RU58841, suggesting they may have been sold an incorrect product from their supplier.

community Quitting Alfatradiol after 4 months

in Product 5 upvotes 1 year ago

The user stopped using Alfatradiol after 4 months due to no hair improvement and side effects like dry scalp and gallbladder pain. They are considering trying topilutamide, which is suggested as an alternative.

community Source for Pyrilutamide has disappeared

in Treatment 21 upvotes 3 years ago

Anageninc stopping the sale of Pyrilutamide due to a cease and desist order from Kintor, with some speculating that it was either a hoax or subpar product.

community Pyrilutamide at 16 years old- update 2

in Research/Science 21 upvotes 3 years ago

A 16-year-old researching and trying Pyrilutamide for hair loss treatment, reporting back on side effects experienced after one week of use; the reported side effects included testicle pain, headache, and increased shedding. Libido and sexual performance seemed unaffected.

community Using topical finasteride/minoxidil while wife is pregnant

in Finasteride/Dutasteride 17 upvotes 2 years ago

A user applies topical finasteride and minoxidil for hair loss and is concerned about the risk to his pregnant wife. It's suggested that topical treatments could be hazardous to a male fetus, and switching to oral finasteride might be safer.

community Topilutamide (fluridil) raw active?

in Research/Science 7 upvotes 5 years ago

Topilutamide is a potential hair loss treatment between Clascoterone and RU58841. Users discuss finding Topilutamide powder and its possible benefits for those who can't afford or tolerate other treatments.

community Stopping Dutasteride to have a baby

in Finasteride/Dutasteride 70 upvotes 1 year ago

A user plans to stop Dutasteride to conceive a child, seeking advice on hair maintenance. Suggestions include switching to Finasteride, but many emphasize prioritizing child safety.

community Dutasteride causing us to have… girl babies?

in Finasteride/Dutasteride 26 upvotes 3 years ago

User Kylo313 used dutasteride for 20 years and had two daughters, questioning if dutasteride affects the likelihood of having male vs female children. Replies mostly request hairline photos and discuss anecdotal experiences, with some suggesting correlation doesn't imply causation and that gender determination isn't affected by dutasteride.

community Starting Pyrilutimide 5% Update

in Treatment 1 upvotes 2 years ago

The user started using Pyrilutamide 5% for hair loss and has not experienced side effects after two days. They previously had side effects from Fluridil and topical Minoxidil 5%, and their hair continued thinning with topical Spironolactone.

community Koshine 826 (Pyrilutamide). Any results after 5 months since it's been released?

in Product 12 upvotes 1 year ago

Koshine 826 (Pyrilutamide) has mixed reviews, with some users experiencing side effects like insomnia and others seeing minimal results. Concerns about the company's transparency and lack of progress photos are noted.

community Kintor develop GT20026 Anti-Androgen receptor drug with NO SIDES

in Treatment 18 upvotes 5 years ago

The conversation discusses GT20029, a new topical drug for hair loss and acne without notable side effects, which has been accepted for investigational use in China. Some users express skepticism about the legitimacy of the company and the potential for other drugs like RU58841 to be developed due to patent expiration and lack of profitability.

community Oral PTD-DBM available online, worth giving a shot?

in Research/Science 4 upvotes 6 years ago

Oral PTD-DBM was discussed as a potential hair loss treatment, but it was deemed ineffective in humans despite promising results in mice. The conversation concluded that trying it without VPA might be unwise.

community Kintor pyrilutamide presentation?

in Research/Science 12 upvotes 3 years ago

The conversation is about whether the phase 2 results for pyrilutamide, a potential hair loss treatment, were presented at a dermatology convention and inquiries about the completion of phase 3 trials. Specific treatments mentioned include pyrilutamide.

community First patient dosed with Pyrilutamide (Kintor) Phase III

in Research/Science 199 upvotes 4 years ago

First patient dosed with Pyrilutamide (Kintor) Phase III for hair loss treatment. Pyrilutamide differs from approved treatments as it competes with DHT to bind hair follicles, potentially reducing side effects.

community A concern regarding the upcoming androgen degrader drug GT20029

in Chat 11 upvotes 1 year ago

GT20029 is a topical treatment that degrades androgen receptors to prevent hair thinning and loss, potentially offering fewer side effects than systemic treatments like finasteride. Concerns include its impact on hair texture and potential systemic effects, with market availability speculated in 3 to 5 years.