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      community Please stop looking for a natural way to stop your hairloss

      in Chat  247 upvotes 4 years ago
      There is no natural way to stop hair loss; pharmaceuticals like minoxidil, finasteride, and RU58841 are the only effective treatments. Some users report success with minoxidil and microneedling, while others discuss the side effects of finasteride.

      community Journey against alopecia - Finasteride 3 month

      in Progress Pictures  18 upvotes 4 years ago
      A 26-year-old man from France started experiencing hair loss in September 2020 and began using finasteride in June 2021, reporting some improvement after three months without side effects. He plans to continue finasteride for a year before considering additional treatments like minoxidil or dermarolling.

      community Why don't more people here use oils?

      in Treatment  19 upvotes 6 years ago
      The conversation discusses using oils like pumpkin seed, rosemary, peppermint, and grape seed oil for hair regrowth, claiming they can be as effective as finasteride or minoxidil without side effects. Some users remain skeptical and prefer proven treatments like minoxidil.

      community Where can I get this topical solution compounded?

      in Treatment  1 upvotes 2 months ago
      A user is seeking a pharmacy to compound a topical solution containing Minoxidil, Finasteride, Alfatradiol, Melatonin, Latanoprost, and either RU58841 or Pyrilutamide. They prefer a professional compounding lab over DIY methods.

      community Topical 5% minoxidil vs compounded topical spray

      in Minoxidil  3 upvotes 1 week ago
      A user is considering switching from regular 5% minoxidil foam to a compounded 5% minoxidil spray with added caffeine, melatonin, and tretinoin for easier application and potentially better results. Another user mentions that tretinoin can enhance minoxidil's effectiveness by converting it to its active form.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Kintor Pharma Announces Positive Top-line U.S. Phase I Trial Results of GT20029, the World’s First Topical Use PROTAC Compound

      in Research/Science  128 upvotes 3 years ago
      The conversation discusses positive initial trial results for GT20029, a topical compound for hair loss that degrades androgen receptors, potentially requiring only weekly application. Participants express hope for this treatment to be more effective and convenient than current options like Minoxidil, Finasteride, and RU58841.

      community Topical solution recommendation

      in Product  1 upvotes 8 months ago
      The user is using finasteride 1mg every other day and seeks a topical solution to complement it, excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

      community Combining Ru58841 with my Topical Formula

      in Research/Science  3 upvotes 9 months ago
      A user is combining RU58841 with a topical formula containing finasteride, dutasteride, minoxidil, triamcinolone, caffeine, and other ingredients. They have just started using it and report no side effects so far.

      community What about azelaic acid, retinol and caffeine, all topical?

      in Minoxidil  7 upvotes 4 years ago
      The conversation is about a user inquiring about a hair loss treatment product that contains minoxidil, azelaic acid, retinol, and caffeine, and whether it is more effective than Regaine foam. No specific treatments or outcomes are discussed.

      community GT20029. Kintor Pharma’s Product

      in Research/Science  12 upvotes 3 years ago
      The conversation discusses GT20029, a compound by Kintor Pharma that degrades androgen receptors and is in trials, with potential as a hair loss cure. Another promising treatment mentioned is an antibody that blocks prolactin and has shown positive results in macaques.

      community Topical solution recommendation

      in Treatment  2 upvotes 8 months ago
      The user is using finasteride 1mg every other day and seeks a topical solution excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

      community Patent for topical resveratrol and melatonin for AGA

       5 upvotes 6 years ago
      The conversation discusses a patent for using topical resveratrol and melatonin to treat androgenetic alopecia (AGA) and also mentions interest in topical sulforaphane as a treatment.

      community Possible natural pp405 solution

      in Research/Science  45 upvotes 8 months ago
      Rotenone, a natural plant extract, may promote hair growth by increasing LDH activity and blocking MPC in the scalp, but it carries risks due to its toxicity. The suggested formulation includes Barbasco extract, DMSO, propylene glycol or PEG-400, ethanol, and a carrier oil.

      community Any other treatments to still be hopeful for?

      in Research/Science  20 upvotes 2 years ago
      The conversation discusses the potential of new hair loss treatments, with a focus on pyrilutamide, gt20029, and topical alfatradiol, and the possibility of improving their effectiveness through methods like increased concentration and microneedling. Dutasteride is also mentioned as a stronger option.

      community The best vehicle/carrier for RU58841

      in Treatment  2 upvotes 2 years ago
      The conversation is about the best vehicle for RU58841, comparing trichosol and Garnier/Vichy Stemoxydine, avoiding propylene glycol (PG) or ethanol due to previous scalp damage. The user is also seeking sources for these products in the EU.

      community Pyrilutamide ,the molecule’s true nature

      in Research  302 upvotes 1 year ago
      Pyrilutamide is a selective AR antagonist with a high binding affinity, making it effective in competing with DHT for androgen receptors. The 1% concentration is more effective than the 0.5%, but the latter may suffice for mild hair loss; the drug is considered a good option for those avoiding 5AR blockers due to side effects.

      community Betamethasone dipropionate 0.05 (sernivo spray)

      in General  76 upvotes 1 year ago
      A user was prescribed betamethasone dipropionate spray for a receding hairline, which caused skin peeling and depigmentation. They stopped using it and are considering alternatives like BPC-157/TB-500 for healing.

      community Opinions on the “best” topical out there?

      in Treatment  1 upvotes 4 months ago
      The conversation is about choosing effective hair loss treatments, specifically discussing RU58841, 5% minoxidil, copper peptides, microneedling, finasteride, dutasteride, and Tretinoin. The user seeks advice on the best topical treatments and prefers to use only 1-2 products.

      community Peptide Therapy -> GHK-CU, ZN-Thumulin, PTD-DBM

      in Research/Science  4 upvotes 2 years ago
      The conversation is about the use of peptide therapies for hair loss, specifically GHK-CU, ZN-Thymulin, and PTD-DBM. The user is seeking feedback on the effectiveness of these treatments from those who have tried them.