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GlossaryThyrotropin-Releasing Hormone

hormone from the hypothalamus that stimulates thyroid-stimulating hormone release

Thyrotropin-Releasing Hormone (TRH) is a hormone produced in the hypothalamus, a region of the brain. It stimulates the pituitary gland to release thyroid-stimulating hormone (TSH), which in turn prompts the thyroid gland to produce thyroid hormones. These thyroid hormones are crucial for regulating metabolism, energy levels, and overall growth and development.

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community 16 months finasteride progress but slowly losing hair again

in Progress Pictures 143 upvotes 1 year ago

A 21-year-old male experienced initial success with finasteride for 16 months but is now losing hair again. He is considering switching to dutasteride and adding oral minoxidil, while also investigating environmental and health factors.

community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 39 upvotes 3 years ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

community Trestolone (MENT) as a nuclear treatment

in Treatment 99 upvotes 3 years ago

Experimenting with trestolone as a treatment for hair loss in an attempt to avoid DHT-related treatments such as finasteride and dutasteride, and discussing the potential effects of its receptor selectivity on the androgen receptors in the scalp.

community TRT. Pyrilutamide. Ru58841. Help

in Treatment 3 upvotes 2 years ago

A 30-year-old man experienced significant hair loss after starting testosterone replacement therapy (TRT), which did not improve with daily finasteride and minoxidil. He is considering restarting TRT and is seeking advice on using pyrilutamide or RU58841 to prevent further hair loss.

community 21m, curious about what's going on with my hair

6 upvotes 11 years ago

A 21-year-old male with a thyroid condition noticed his hair thinning uniformly without a receding hairline. He is considering using a 5ARI to prevent further baldness if he starts TRT.

community What factors cause more regrowth for MTF people with hormone replacement therapy?

in Transgender 5 upvotes 3 years ago

Hair regrowth in transfems is more effective due to hormonal changes, specifically estrogen, which keeps hair in growth phase longer. Treatments mentioned include anti-androgens, sex hormones, and DHT blockers like finasteride.

community Since there is so much hype for cosmeRNA and HMI-115...

in Chat 44 upvotes 3 years ago

Exploring different treatments for hair loss, such as cosmeRNA and HMI-115 which are small interference messenger RNA that inhibits the DHT receptor and an antibody that binds to the prolactin (PRL) receptor respectively; and researching mechanism and environment of hyperresponders.

community Positive Hair Result in Patient using Tirzepatide

in Research/Science 5 upvotes 1 year ago

A 57-year-old man with male pattern hair loss and insulin resistance experienced hair regrowth and weight loss after using tirzepatide, without other hair treatments. Dysregulated glucose metabolism is linked to hair loss, with tirzepatide potentially improving hair density by normalizing insulin resistance.

community How well can HRT reduce scalp tension?

in Transgender 4 upvotes 3 years ago

A trans woman is curious about the impact of HRT on hair regrowth and scalp tension. Her current regimen includes finasteride, spironolactone, estradiol, ketoconazole, vitamin D, iron, and plans to add oral minoxidil and restart derma rolling.

community GT20029. Kintor Pharma’s Product

in Research/Science 12 upvotes 3 years ago

The conversation discusses GT20029, a compound by Kintor Pharma that degrades androgen receptors and is in trials, with potential as a hair loss cure. Another promising treatment mentioned is an antibody that blocks prolactin and has shown positive results in macaques.

community Taking HRT medication not only cured my thinning hair, it gave me better hair than I ever had before

in Transgender 12 upvotes 7 months ago

Hormone replacement therapy with spironolactone and estradiol significantly improved hair thickness and growth, surpassing previous treatments like dutasteride, finasteride, and minoxidil. The user experienced regrowth in receded areas and a more youthful appearance.

community Does anyone think their hair loss is thyroid related?

in Chat 11 upvotes 1 year ago

Hair loss may be linked to thyroid issues, with some individuals noticing changes in hair texture when taking substances affecting the thyroid. Treatments mentioned include a topical mix of finasteride, minoxidil, and tretinoin, along with microneedling.

community Temple recession continues, 19 MtF, Monotherapy w/ confirmed low T, also taking 1.25mg Finasteride,

in Transgender 115 upvotes 8 months ago

A 19-year-old transgender individual is experiencing worsening temple recession despite taking female hormones and 1.25mg finasteride. They are seeking advice on additional treatments to address hair loss.

community Topical T3 study - 1000% Growth. Anyone tried it?

in Research/Science 101 upvotes 4 years ago

The conversation discusses using T3 (triiodothyronine) as a topical treatment for hair growth, with some users noting it showed promising results in studies but lacked follow-up. Users express interest in trying T3 due to its potential effectiveness compared to Minoxidil.

community Hair regrow idea: High dose Testosterone + RU58841

in Satire 2 upvotes 1 month ago

Using high doses of testosterone with RU58841 to create an androgen-free environment for hair regrowth is suggested, but concerns about heart health and the effectiveness of this approach are raised. Alternatives like topical estrogen, progesterone, and other treatments like finasteride and dutasteride are discussed.

community Diffuse Thinning From Low Iron and Thyroid -Finally Seeing Regrowth After Fixing the Root Cause

in Female 26 upvotes 8 months ago

A female experienced hair loss due to low iron and an undiagnosed thyroid issue, specifically Hashimoto's, and saw improvement after starting thyroid medication, iron supplements, and making lifestyle changes. She emphasizes the importance of addressing the root cause and shares her journey to regrowth and emotional recovery.

community Kintor Pharma Announces Completion of Subject Enrollment and Dosing in Phase I Clinical Trial of AR-PROTAC(GT20029) in the US_Kintor Pharmaceutical Limited

in Research/Science 58 upvotes 3 years ago

Kintor Pharma finished enrolling and dosing participants in a Phase I trial for a hair loss treatment called AR-PROTAC (GT20029). The effectiveness of another drug, pyrilutamide (KX-826), for hair loss will be clearer after a Phase 2 trial expected to complete in January 2023.

community DHT levels and correlation to hair loss

in Chat 3 upvotes 8 months ago

The user experienced hair shedding after starting testosterone replacement therapy (TRT) and is considering using DHT blockers like finasteride or dutasteride to address potential DHT-related hair loss. Low ferritin levels due to frequent blood donations may also contribute to hair issues, and the user is working on stabilizing iron levels.

community Potential role of TB-500 Thymosin Beta-4

in Technology 8 upvotes 1 year ago

The conversation discusses hair loss treatments, specifically mentioning Minoxidil, finasteride, RU58841, and TB-500 Thymosin Beta-4. It critiques the credibility of biohacking claims.

community Prolactin's role in antitumor activity of the immune system - a safety concern for HMI-115?

in Research/Science 4 upvotes 3 years ago

Hair loss discussion includes treatments Minoxidil, Finasteride, and RU58841. Prolactin's role in immune system's antitumor activity raises safety concerns for HMI-115.

community 19M on HRT Concerned About Hairline Receding; Finasteride Concerns

in Transgender 183 upvotes 11 months ago

A trans man is experiencing hair loss due to testosterone therapy but is unwilling to stop the treatment despite concerns about using finasteride. The individual is distressed about balding at a young age but acknowledges it is genetic.

community (MTF 35) Results of 18 Months of HRT

in Transgender 783 upvotes 6 months ago

A transgender woman experienced significant hair regrowth after 18 months of hormone replacement therapy (HRT) with estrogen and bicalutamide. The discussion notes HRT's effectiveness for hair regrowth but warns against its use for cisgender men due to feminizing effects.

community MTF why am I suddenly shedding hair of exactly the same length

in Transgender 4 upvotes 4 years ago

The user experienced hair shedding after increasing minoxidil from 5% to 7% with latanoprost, possibly causing telogen effluvium. They are on HRT with Lupron, Estradiol, and Raloxifene, and are concerned about the shedding's duration.

community A list of top hyperresponders of /tressless with a data array for studying the phenomenon

in Research 155 upvotes 2 years ago

The conversation is about treatments for androgenetic alopecia, focusing on hyperresponders. Treatments include Minoxidil, finasteride, RU58841, leg training, and cold therapy.

community Running Gear- Preemptive Treatment

in Product 8 months ago

A 51-year-old on TRT plans to use steroids and is concerned about hair loss, considering topical treatments like Hair Rescue with RU58841 and finasteride, along with Nioxin shampoo. They are cautious about using oral DHT blockers due to potential interactions with steroids like Tren and Anavar.

community Article of all potential future cures

in Treatment 25 upvotes 1 year ago

Ritlecitinib and PP405 show promise for hair regrowth. Diagnosing the cause of hair loss is crucial before treatment.

community Hair loss at age 23... Thyroid t4 value of 0.8

4 upvotes 8 years ago

A 23-year-old is experiencing hair loss, primarily at the top middle of the head, and is considering finasteride but is hesitant due to potential side effects. Other users share their positive experiences with finasteride, suggesting it is worth trying, while also discussing the importance of researching and monitoring for any side effects.

community r/tressless members when encountering people with good hair genetics

in Satire 290 upvotes 3 years ago

Hair loss discussion includes treatments like Minoxidil, Finasteride, and RU58841. Users share experiences and support, mentioning that many people face hair thinning.

community Kintor Pharmaceutical Announces AR-PROTAC (GT20029) Approved for Acne and Androgenic Alopecia Clinical Trials in China

in Technology 13 upvotes 5 years ago

The conversation discusses the approval of Kintor Pharmaceutical's AR-PROTAC (GT20029) for clinical trials in China for acne and androgenic alopecia. One user expresses optimism about new treatments being developed and seeks clarification on how the new drug works, specifically if it temporarily degrades the AR protein to reduce DHT sensitivity in hair follicles.

community 21 months on topical minoxidil and full HRT

in Transgender 214 upvotes 2 years ago

The conversation is about a transgender individual's experience with hair regrowth using topical minoxidil and hormone replacement therapy (HRT), expressing concern about the slow growth and thin appearance of their hair. Some responses encourage patience and highlight the variability of results, while others discuss the role of HRT and its effects.