community U.S Court let Merck hide secrets about Finasteride.
Hair loss discussion involving finasteride's side effects and effectiveness. Users shared mixed experiences, with some reporting side effects and others seeing positive results.
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30 / 1000+ resultscommunity Whoever had success with PYRILUTAMIDE, please give us hope outside of 5AR inhibitors.
Users discuss using pyrilutamide for hair loss, seeking alternatives to 5AR inhibitors. They mention using minoxidil, ketoconazole shampoo, and RU58841.
community Kintor Phase 2 Results released KX-826 (pyrilutamide)
Kintor Pharmaceutical's Phase 2 results with the drug Pyrilutamide, a potential alternative to 5-ARI drugs like Finasteride and Dutasteride but without the side effects. It could be used in combination with other topical treatments such as Minoxidil. The safety of the drug has been demonstrated in 6 months of use, however there are still questions about long term efficacy and systemic absorption.
community Warning: Minoxidil usage around pets
Minoxidil is highly toxic to pets, especially cats and dogs, even in small amounts. Many users have switched to oral minoxidil to prevent accidental exposure to their pets.
community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?
The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.
community New update. 16 months on finasteride, 25 year old, 1.25mg daily. The first picture is a screenshot from a video taken in February 2023, hence the quality is kinda poor.
A 25-year-old user shared progress pictures after 16 months of using 1.25mg daily finasteride for hair loss, reporting noticeable results around months 4-5 and some initial side effects that resolved. The user experienced thickening and slight regrowth of the hairline.
community Pyrilutamide Phase 3 on its way
Pyrilutamide Phase 3 approved, starting early 2022 with 416 subjects for 24 weeks. Drug potentially better than RU and Breezula, with some users reporting no side effects.
community Publication concludes finasteride is a associated with a 60% risk of persistent sexual dysfunction.
Finasteride is not linked to a 60% risk of persistent sexual dysfunction; this figure applies only to those already experiencing sexual issues. Most users do not have side effects, and the study's methodology is criticized for selection bias.
community Why do so many people trash on finasteride?
Finasteride is effective for hair regrowth, especially on the crown, but can cause side effects like reduced libido and erectile dysfunction in some users. Opinions are mixed, with some reporting positive results without side effects and others experiencing significant issues.
community Is pyrilutamide safe to use or still unknown?
The conversation is about the safety and effects of using pyrilutamide for hair loss. One person reported severe negative effects, another experienced minor side effects without much benefit for hair, and a third found the anecdote helpful in making a decision.
community Can't believe I've slept on microneedling for so long.
Microneedling with minoxidil and finasteride greatly improves hair regrowth. Using 0.5mm depth every other day boosts minoxidil absorption without side effects.
community Just had this wild thought come into my head.
The conversation is about the debate over the existence of Post-Finasteride Syndrome (PFS) and its symptoms, with some users skeptical about PFS and others discussing side effects like erectile dysfunction and gynecomastia from hair loss treatments like finasteride. Specific treatments mentioned include finasteride, viagra, and a joke about using a popsicle stick for erectile support.
community HLT Megathread on HMI-115 (key takeaways in comments)
HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.
community This sub in a nutshell when it comes to medicine. Oral Minoxidil isn’t that bad
The post and conversation are about the use of oral Minoxidil (Min), Finasteride (Fin), and RU58841 for hair loss treatment, with mixed opinions on their safety and effectiveness.
community Transient and Permanent Effects of Finasteride Use
Potential side effects of 5AR inhibitors like finasteride and dutasteride. Users debate risks, benefits, and personal experiences with these hair loss treatments.
community Popular hair loss drug linked to higher suicide risk: compared to non-users, finasteride (Proscar/ Propecia) users have a markedly increased risk of depression, anxiety, and suicidal thoughts. Over 30 years of observation, 19,320 suicides were expected.
Finasteride users may have an increased risk of depression, anxiety, and suicidal thoughts, though some attribute these issues to hair loss itself. The link between finasteride and mental health effects is debated, with varying user experiences.
community Why don’t people just just DUT instead of FIN?
The conversation discusses the use of dutasteride (DUT) versus finasteride (FIN) for hair loss treatment, with some users preferring DUT for its effectiveness while others choose FIN due to its approval status, better long-term data, and lower risk of side effects. Users share personal experiences with both medications, including side effects and effectiveness.
community KX-826 Phase 3 Failed. Sorry guys...
The conversation discusses the failure of Phase 3 trials for the hair loss treatment KX-826, with no significant difference found between the drug and placebo. Some users express disappointment and skepticism, while others discuss alternative treatments like Minoxidil, finasteride, and RU58841.
community Why is Finasteride seen as “scary” for men, but hormonal birth control is totally normalized for women?
Finasteride is seen as risky for men due to side effects like erectile dysfunction, while hormonal birth control for women is normalized despite its side effects. The discussion points out a double standard influenced by societal and gender norms.
community People are misunderstanding PP405. 31% response at 8 weeks is better than you think
PP405 shows promise as a hair loss treatment, with 31% experiencing increased hair density in a short trial. It may complement treatments like finasteride and minoxidil, but long-term effectiveness and safety need confirmation.
community Finasteride/dut. causes NAFLD,IR,diabetes,kidney dysfunction is it correct.
Hair loss discussion mentions treatments like Finasteride, Dutasteride, and Minoxidil. Users share experiences, side effects, and advice on using these treatments.
community PSA: Not all Finasteride generics are created equal, effectiveness and severity of side-effects can vary by manufacturer.
Switching generic finasteride manufacturers can reduce side effects while maintaining effectiveness. Different fillers in generics may affect bioavailability and cause varying side effects.
community Post Finasteride Syndrome, A dangerous lie.
A user initially had side effects from finasteride, attributed them to anxiety and the nocebo effect, and after resuming the drug, experienced positive effects and now warns against misinformation about Post Finasteride Syndrome.
community People's ignorance on MPB is both frustrating and harmful to balding men and it's important to educate other balding men on Fin/Min/Dut (Discussion)
Many are unaware of effective male pattern baldness treatments like finasteride and minoxidil, often opting for ineffective remedies. Educating others on proven treatments and potential side effects is crucial.
community Finasteride and fertility. Personal report.
Finasteride can affect sperm quality, but fertility usually returns after stopping it, as shown by a user who conceived four months after discontinuation. Some users successfully conceive while on finasteride, though some prefer to pause its use to minimize risks.
community If you're sitting there wondering, "I'm losing my hair, what do I do?" then read my advice here. I've been fighting the fight for 7 years, with great success. (pictures included)
Fighting hair loss with "The Big 3" treatments of Propecia, Rogaine and Nizoral shampoo, as well as specific advice on how to use these products. People have shared their long-term success stories and some have discussed the side effects of finasteride. Other suggestions included Lipogaine and Pura D'or Hair Loss Prevention Therapy Shampoo & Conditioner.
community Quick rant about fin/dut posts on this sub.
Hair loss treatments Finasteride and Dutasteride are discussed, with emphasis on their safety and effectiveness. Users share frustration about fear-mongering and side effect discussions, suggesting trust in scientific studies and FDA approval.
community Approximation of Scalp DHT Suppression Between 0.05 mg to 2.5 mg
The conversation discusses the effectiveness of various doses of Dutasteride in reducing scalp DHT and its impact on hair count. Users shared personal experiences with hair loss treatments, including Dutasteride, Finasteride, and Minoxidil, with one reporting significant hair loss reduction using a combination of oral Dutasteride and topical Minoxidil and Finasteride.
community How many years can we expect PP405 to be on the market
PP405 is expected to be on the market between 2027 and 2030, with phase 3 trials starting in 2026. There is skepticism about its fast-tracking due to its cosmetic nature, and it may appear on the gray market sooner.
community HairCafe: The Broscience of Hair Loss, DHT, and Bludflow with Andrew Huberman
Hair loss, DHT and bloodflow with Andrew Huberman; the discussion includes opinions about supplements, finasteride, minoxidil, turmeric, coffee and botox injections for hair loss.