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GlossaryUltraviolet A

long-wavelength ultraviolet light that penetrates deeply into the skin

Ultraviolet A (UVA) is a type of ultraviolet radiation with wavelengths ranging from 320 to 400 nanometers. It penetrates the skin more deeply than UVB, contributing to skin aging and long-term skin damage, and is also implicated in the development of some skin cancers. UVA is commonly encountered in sunlight and is also used in tanning beds.

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community Evolution theory: AGA is your body trying to reduce the risk of prostate cancer by exposing your scalp to more UV

in Research/Science 6 months ago

Androgenic alopecia (AGA) might have evolved to reduce prostate cancer risk by increasing UV exposure to the scalp, but this theory is debated. Treatments like minoxidil and finasteride are used for AGA, though the exact causes and evolutionary reasons for hair loss are unclear.

community What About Phytosterol Alternatives - Rice Bran Oil - Natural DHT Blockers

in Research/Science 4 upvotes 2 years ago

The conversation discusses natural DHT blockers like rice bran oil, which may reduce 5α-reductase activity similarly to Minoxidil and Dutasteride. One user argues that finasteride is more reliable and effective than natural alternatives.

community The Health Benefits of Head Hair

in Research/Science 19 upvotes 8 months ago

Hair provides protection against head trauma, reduces skin cancer risk, helps remove heavy metals, and aids in wound healing. The conversation emphasizes the health benefits of maintaining head hair beyond cosmetic reasons.

community Tretinoin can make it worse!!!

in Chat 7 upvotes 2 years ago

Tretinoin may enhance minoxidil's effectiveness for those not responding to minoxidil alone, but it could reduce efficacy for some who are already responding to minoxidil. Tretinoin requires careful use, including skin moisturizing and sun protection due to increased sensitivity.

community any news about DUPA (Diffuse unpatterned alopecia)?

in Research/Science 8 upvotes 3 years ago

The conversation discusses diffuse unpatterned alopecia (DUPA) and its possible causes, including sensitivity to DHT, not being androgenic alopecia, being diffuse alopecia areata, or hormonal issues. Treatments mentioned include topical melatonin, Clobetasol Propionate for alopecia areata, and the lack of results from using finasteride, dutasteride, and minoxidil.

community Does pyri/kx826 degrade in exposure to bathroom light?

in Treatment 5 upvotes 1 year ago

The conversation discusses concerns about RU58841 degrading when exposed to light and transferring pyri to a dark glass bottle to prevent this. The user keeps the pyri out for only two minutes before storing it in a dark place.

community Scalp Sunburns can cause permanent hair loss. UPF hats protect you.

in Technology 1 year ago

Scalp sunburns can cause permanent hair loss, so wearing UPF hats is essential. Tretinoin and Tacrolimus users should be cautious of increased photosensitivity and potential scalp issues.

community DUPA - Impossible to cure, so giving up

in Update 3 upvotes 9 months ago

The user diagnosed with DUPA tried treatments like dutasteride, finasteride, RU58841, and minoxidil without success and is considering a hair system. They hope for a future cure, possibly with PP405, and others suggest options like scalp biopsy and SMP.

community Scalp Sunburns cause permanent hair loss. UPF hats protect you. Watch if you use Tretinoin on the scalp

in Technology 1 year ago

Sunburns on the scalp can cause permanent hair loss, especially for those using Tretinoin or Tacrolimus. Wearing UPF 50+ hats is recommended to protect against UV radiation.

community AH-001 another topical AR degrader beside GT20029, completed Phase I

in Research/Science 10 upvotes 7 months ago

AH-001 is a new topical treatment designed to degrade androgen receptors, targeting the root cause of androgenetic alopecia without the side effects of oral treatments like finasteride. It has shown a strong safety profile and good local tolerability in early trials.

community Verteporfin (Visudyne) group buy 🌷

in Treatment 29 upvotes 4 years ago

User seeks participants for Verteporfin group buy. Verteporfin, FDA approved, may regenerate hair follicles and sweat glands through heavy microneedling.

community Treating my DUPA via controlling inflammation

in Treatment 5 upvotes 2 years ago

The user has DUPA and suspects autoimmune activity as a cause. They have tried various treatments including finasteride, minoxidil, dutasteride, pyrilutamide, estrogel, hydrocortisone, and clobetasol, and are now seeking a long-term immunosuppressant.

community Best Treatment In The Pipeline?

in Chat 15 upvotes 1 year ago

New treatments for AGA are emerging, including pyrilutumide, gt0029, scube3, kx-826, and pp405. Verteporfin is mentioned as a promising option.

community topical fluridil/eucapil + dut to block all DHT+T from scalp?

in Treatment 8 upvotes 4 years ago

User experienced slow gains with topical fin+min, switched to topical dut+min, and considered adding Eucapil. Another user suggested DUT may be less effective topically due to high molar mass and mentioned Fluridil as a weak anti-androgen that could help.

community EMA is re-examining Winlevi (clascoterone at lower concentration)

in Treatment 8 upvotes 11 months ago

Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.

community My experience and a discourse on “DUPA”

in Chat 46 upvotes 3 years ago

How diffuse unpatterned alopecia (DUPA) is not an invitation to self-diagnose oneself with aggressive AGA and that seeking a specialized dermatologist may help people experiencing hair loss. Treatment options discussed include topical clobetasol propionate, oral minoxidil, and discontinuing finasteride.

community Fluridil/Eucapil UAE customs regulation

in Chat 1 year ago

A user in the UAE is facing customs issues with ordering Fluridil (Eucapil) and is considering ordering smaller quantities or switching to Pyrilutamide. They are also using finasteride daily to maintain hair and are unsure of Fluridil's effectiveness.

community Thoughts on Avixis Alfatradiol?

in Product 4 upvotes 4 years ago

Avixis Alfatradiol is a topical 5-alpha reductase inhibitor available in Latin America and Germany, but its effectiveness is questioned. A user reported worsened hair loss after using it and recommended finasteride instead due to its proven effectiveness and lower cost.

community Eucapil, Fluridil update from manufacturer

in Treatment 5 upvotes 11 months ago

The user is experiencing hair loss after a hair transplant and is considering using fluridil (Eucapil) and possibly alfatradiol as treatments, as they couldn't tolerate finasteride or minoxidil. The manufacturer of Eucapil confirmed they won't produce higher concentrations due to lack of efficacy.

community Ru delivery and heat outside .

in Treatment 1 upvotes 11 months ago

The conversation discusses concerns about the effectiveness of RU58841 due to high temperatures during delivery. A user reassures that the heat will not affect its efficacy.

community Advanced AGA and DUPA at 25. Starting Nuclear Stack: Day 1

in Treatment 14 upvotes 3 years ago

User starts Nuclear Stack treatment for hair loss, including Dutasteride, Minoxidil, RU58841, Derminator 2, and supplements. Seeks advice on storing and dosing RU58841.

community Just took a pic of my hair under direct sunlight for the first time in months. Instant regret.

in Chat 16 upvotes 5 years ago

The conversation is about disappointment with hair loss progress despite using treatments like finasteride, minoxidil, nizoral, tretinoin, and a dermaroller. Direct sunlight revealed more hair loss than expected, prompting continued treatment and hope for improvement.

community Betacaroten and hairloss? Make it better or Worse?

in Treatment 1 upvotes 4 years ago

Betacarotene's effect on hair loss is discussed, with concerns about excessive vitamin A. The user also questions if 15mg melatonin impacts vitamin A levels.

community DHEA, the culprit behind DUPA ? Read this!

in Research/Science 19 upvotes 2 years ago

High DHEA levels may contribute to hair loss by increasing DHT in hair follicles, potentially explaining why finasteride is ineffective for some. Treatments like high-dose dutasteride and RU58841 are suggested, but the underlying cause, such as adrenal issues, should be investigated.

community DUPA hair loss - What's the real deal ?

in Research/Science 10 upvotes 3 years ago

A 25-year-old male with DUPA (diffuse thinning including the donor area) has not seen improvement after 14 months on finasteride. He's considering switching to dutasteride (DUT) after advice from a hair loss YouTuber and is also contemplating trying RU58841.

community PG causing irritation when applying RU

in Research/Science 2 years ago

The user is experiencing irritation from using PG with RU58841 and is seeking alternative solutions like K&B in the UK. They report redness, itchiness, and flaky skin from the current treatment.

community Advanced AGA and DUPA at 25. Starting Nuclear Stack: Day 178 (6 months-ish)

in Update 7 upvotes 2 years ago

A user is treating hair loss with Dutasteride, Minoxidil, RU58841, Derminator 2, Vitamin D, Biotin, and Zinc. After 6 months, there's no significant visual improvement, but the user feels less insecure about Retrograde Alopecia.

community Pp405 AAD presentation tomorrow - fingers crossed - what to expect?

in Research/Science 84 upvotes 3 months ago

New hair loss treatments PP405 and VDPHL01 are discussed with skepticism and hope, alongside existing treatments like minoxidil and finasteride. Users express frustration over limited progress since the 1980s but remain cautiously optimistic.

community Anything stronger than DUT out there?

in Finasteride/Dutasteride 14 upvotes 2 years ago

The conversation discusses seeking a stronger treatment than Dutasteride (DUT) for hair loss. Suggestions include combining DUT with RU58841, increasing DUT dosage, and using transgender hormone replacement therapy or testosterone blockers, though some options may have feminizing side effects.

community 0.25 alfatradiol or 0.5 Pyrulitamide ?

in Product 4 upvotes 8 months ago

The conversation is about choosing an anti-androgen for hair loss treatment, with options being alfatradiol and pyrilutamide. Alfatradiol is considered a better choice due to its established use, while pyrilutamide is more experimental.