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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Anyone hear of Ursolic Acid?

      in Question  4 upvotes 7 years ago
      Ursolic acid, found in apple peels, lemongrass, rosemary, and lavender, may have anti-androgen effects similar to finasteride. It might be beneficial for hair health when used with other treatments like Minoxidil, Finasteride, and RU58841.

      community Minoxidil asking advice as an 23F

      in Minoxidil  1 upvotes 2 months ago
      A 23-year-old woman is considering starting minoxidil for hair thinning but is concerned about its long-term use and effectiveness. Recommendations include consulting a doctor, checking ferritin levels, and considering treatments like spironolactone or finasteride, while minoxidil is suggested for regrowth but not as a primary treatment.

      community Possibilities without Fin/Dut ?

      in Treatment  5 upvotes 2 months ago
      The user experiences severe side effects from finasteride and dutasteride, including low libido and anxiety, and is currently using oral minoxidil despite shortness of breath. They are seeking alternative treatments for hair loss, having tried pyrilutamide, fluridil, and RU58841 with no success, and are considering future treatments or a hair transplant.

      community Can I stop oral minoxidil if I'm on HRT?

      in Transgender  2 upvotes 2 years ago
      A person with androgenetic alopecia has seen hair improvement using oral minoxidil and finasteride but is concerned about increased body hair. They want to know if stopping minoxidil while continuing hormone replacement therapy and finasteride will cause hair loss.

      community I might have found hair transplant bug guys

      in Transplants  6 upvotes 9 years ago
      Using finasteride before a hair transplant can prevent further hair loss and make the transplant look more natural. Patients should continue using finasteride until hair cloning becomes available.

      community Hair loss products whilst trying to conceive

      in Minoxidil  1 upvotes 1 year ago
      The conversation is about the safety of using hair loss products like Minoxidil and finasteride while trying to conceive and after birth. The user is seeking advice on whether these products are safe for the baby and if any men in similar situations can share their experiences.

      community Fertility - are/were you able to impregnate your SO while taking hair loss meds (such as fin/min/RU/keto/etc) ? Please share your stories 🙏

      in Treatment  21 upvotes 3 years ago
      People discussed their experiences with hair loss medications like finasteride and minoxidil affecting fertility. Some had successful pregnancies while on these medications, others took breaks from the medications when trying to conceive, and there were mixed opinions on the necessity of stopping treatment for conception and pregnancy.

      community 2nd day on pyrilutamide - what I noticed so far

      in Treatment  7 upvotes 3 years ago
      The user started using a hair loss treatment called pyrilutamide and experienced mild chest discomfort and tightness, similar to previous side effects from RU58841. They plan to reduce the dosage due to these side effects and will provide an update on the results in 1-2 months.

      community 23M Wierd blood test results after 7 months on finasteroid (1mg daily)

      in Finasteride/Dutasteride  6 upvotes 4 months ago
      A user experienced unexpected hormone test results after 7 months on 1mg daily finasteride, noting a decrease in estradiol despite expectations of an increase. Other users suggested that hormone responses can vary and that finasteride might still be effective if DHT levels are within range, while also mentioning factors like circadian rhythm and stress that could impact results.

      community I've had a FUE hair transplant in Turkey today. AMA.

      in Transplants  13 upvotes 9 years ago
      A 36-year-old male had a 3000-graft FUE hair transplant in Turkey, with 2000 grafts to the front and 1000 to the crown. Post-operation, he experienced nausea, dizziness, itching, and pain, but saw hair growth and plans to take pictures once redness subsides.

      community How obvious is it that I am using hair fibers to thicken my hairline?

      in Product  175 upvotes 6 months ago
      The user uses Toppik hair fibers to thicken their hairline and has switched from finasteride to dutasteride and oral minoxidil, noticing more hair thickening. Most responses indicate the hair fibers are not noticeable, and many suggest the user doesn't need them as their hair looks natural and good for their age.

      community finasteride vs "natural" DHT blockers

      in Finasteride/Dutasteride  10 upvotes 3 years ago
      The conversation discusses challenges in obtaining finasteride in the Netherlands and explores alternatives like natural DHT blockers and topical finasteride. Suggestions include consulting different doctors or dermatologists and considering cost-effective options like cutting higher-dose tablets.

      community 2.5 years Minoxidil and HRT, CPA->Lupron +Minox 5%

      in Transgender  611 upvotes 1 year ago
      The user experienced significant hair regrowth after 2.5 years of using Minoxidil 5% and hormone replacement therapy (HRT) with Lupron, despite initial scalp irritation. Finasteride was ineffective for them.

      community Are baby hairs growing on fin and min?

      in Is this regrowth?  125 upvotes 2 years ago
      The conversation discusses whether baby hairs observed after using finasteride and minoxidil will grow into terminal hairs, with mixed experiences and opinions shared on the effectiveness of these treatments for hair regrowth. Some users report positive results, while others are skeptical about the potential for significant change.

      community Anybody used Fluridil ? Is my last hope.

      in Finasteride/Dutasteride  5 upvotes 3 years ago
      The conversation is about alternatives to finasteride for hair loss, with suggestions including fluridil, oral minoxidil, alfatradiol, and cb-03-01. Concerns about finasteride's side effects, including potential breast cancer risk, are also discussed.

      community Can finasteride affect on your muscle and other things?

      in Finasteride/Dutasteride  1 upvotes 2 years ago
      The conversation discusses using finasteride topically for hair loss and concerns about potential side effects like feminization and impact on muscle growth. One person shared their experience with finasteride, indicating it increased testosterone and did not prevent them from gaining muscle or strength.

      community 7 months topical fin only trying to fix center of hairline

      in Progress Pictures  4 upvotes 3 weeks ago
      A user is experiencing hair loss in the center of their hairline and has been using topical finasteride for seven months with minimal progress. They are considering switching treatments due to concerns about losing ground and potential side effects of other options.