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      community Since there is so much hype for cosmeRNA and HMI-115...

      in Chat  44 upvotes 3 years ago
      Exploring different treatments for hair loss, such as cosmeRNA and HMI-115 which are small interference messenger RNA that inhibits the DHT receptor and an antibody that binds to the prolactin (PRL) receptor respectively; and researching mechanism and environment of hyperresponders.

      community Why are there no proper phase 3 trials for RU

      in Chat  4 upvotes 3 months ago
      RU58841 lacks FDA approval due to financial and safety concerns, including potential cardiological side effects. The company abandoned further research, and users report adverse effects like heart palpitations and gynecomastia.

      community Losing ground on dut for 1.5y daily

      in Finasteride/Dutasteride  6 upvotes 10 months ago
      The user has been using 0.5mg Dutasteride daily and topical Minoxidil but is experiencing worsening hair density and is considering switching to Finasteride, increasing the Dutasteride dose, or adding RU58841. They are also considering microneedling and have concerns about the effectiveness of generic Dutasteride compared to branded versions.

      community OFFICIAL Multi-Center Verteporfin Trial Recruitment

      in Research/Science  251 upvotes 1 year ago
      Recruitment for a verteporfin trial and a separate hair cloning trial using verteporfin and other methods is underway, with locations in Jordan, NYC, Beverly Hills, and Memphis. Dr. Bloxham is conducting the hair cloning trial, and interested participants are encouraged to contact him directly.

      community Am i being impatient

      in General  1 upvotes 1 year ago
      Minoxidil, finasteride, and RU58841 are discussed as treatments for hair loss. The conversation questions the effectiveness and patience required for these treatments.

      community 5ARI (dutasteride) Associated with Adverse Metabolic Effects

       22 upvotes 8 years ago
      Dutasteride is associated with increased blood glucose, HbA1c, LDL cholesterol, and liver enzyme activity, potentially leading to diabetes, NAFLD, and liver metabolism changes. The conversation highlights concerns about these adverse effects and calls for more studies, including on finasteride.

      community Terrible experience with MV Supplements and no support

      in Product  3 upvotes 2 years ago
      A user had a bad experience with MV Supplements when their Pyril powder and ethanol order leaked during shipping, making the products unusable. Despite contacting support and providing evidence, the company's return policy did not allow for a refund or replacement.

      community My current nuclear stack. Thoughts?

      in Chat  7 upvotes 2 years ago
      The user is using RU58841 twice daily, dutasteride 0.5mg every two days, dutasteride mesotherapy every three months, and 20mg oral minoxidil daily. Other users suggest this regimen is excessive and recommend adding microneedling and ketoconazole shampoo.

      community What happens to the excess testosterone after using dut?

      in Finasteride/Dutasteride  23 upvotes 1 year ago
      Using dutasteride or finasteride can increase free testosterone, which may convert to estradiol, potentially causing side effects like increased estrogen levels. Individual responses vary, and some users report changes in cholesterol, hair texture, and side effects like gyno or increased sex drive.
      18m what norwood is this and what can i do please help

      community 18m what norwood is this and what can i do please help

      in General  162 upvotes 10 months ago
      The user is concerned about hair loss and is using treatments like dutasteride, microneedling, and topical finasteride, while considering adding RU58841. They are also using Minoxidil on the temples and are worried about testosterone-related hair loss.

      community 4 months on dut and topical min as a 23 year old

      in Progress Pictures  76 upvotes 1 year ago
      A 23-year-old shares progress in hair quality after 4 months using dutasteride, topical minoxidil, and other treatments, noting improved crown thickness but persistent temple thinning. They switched from finasteride to dutasteride due to side effects and started testosterone replacement therapy, which they believe helps mitigate side effects.

      community Venting My Frustration with Doctors

      in Chat  14 upvotes 1 year ago
      A 22.5-year-old male is frustrated with doctors for not taking his diffuse thinning seriously. He has been using finasteride for 2.5 years, avoids topical minoxidil due to dandruff, and is hesitant about oral minoxidil due to weight and injury concerns.

      community just saw my hair under harsh sunlight and devastated..

      in Chat  121 upvotes 1 year ago
      The conversation discusses hair loss struggles and treatments, including oral minoxidil, oral finasteride, and RU58841. Users share experiences and advice, suggesting options like topical minoxidil, microneedling, hair transplants, and scalp micropigmentation.

      community Topical VPA - Anyone experiences here?

      in Question  2 upvotes 8 years ago
      The conversation is about using topical valproic acid (VPA) for hair loss, focusing on its application method, usage frequency, and combination with other treatments like micro-needling. No specific experiences with VPA were shared.

      community The best vehicle/carrier for RU58841

      in Treatment  2 upvotes 2 years ago
      The conversation is about the best vehicle for RU58841, comparing trichosol and Garnier/Vichy Stemoxydine, avoiding propylene glycol (PG) or ethanol due to previous scalp damage. The user is also seeking sources for these products in the EU.

      community The case for 5ARI-free hair transplants: Dr. Zarev, Pittella, Sethi, Miln, and future treatments in development

      in Treatment  14 upvotes 7 months ago
      Some individuals experience side effects from 5AR inhibitors like finasteride and are considering hair transplants without these medications, with some opting for surgeons like Dr. Zarev. Others are exploring alternative treatments and waiting for new medications in development, while some discuss managing side effects through lifestyle changes or additional medications.

      community Applying topicals before bed..

      in Treatment  4 upvotes 4 years ago
      Applying hair loss treatments like minoxidil and finasteride, with concerns about side effects and application timing. Some users experience side effects, while others manage without issues, and there's interest in future treatments like pyrilutamide.

      community ashwagandha while taking finasteride

      in Finasteride/Dutasteride  5 upvotes 7 months ago
      The user is considering taking ashwagandha while on finasteride to manage side effects, noting it reduces stress but may cause hair thinning. They are unsure if the thinning is due to ashwagandha or normal shedding from finasteride.

      community Minoxidil: How It Changes the Scalp Hormone Environment

      in Research/Science  80 upvotes 4 months ago
      Minoxidil increases blood supply to the scalp, strengthening dormant follicles and extending the growth phase, but may increase scalp activity that can be countered with DHT blockers. Women experiencing side effects from finasteride or dutasteride for hair loss might consider alternatives like estrogen, especially if on birth control.

      community Using the nuclear stack and still losing hair... Is this the end for my hair?

      in Update  4 upvotes 3 years ago
      The user is experiencing ongoing hair loss despite using a comprehensive treatment regimen including dutasteride, oral minoxidil, cyproterone acetate, transdermal estradiol, and topical bicalutamide. They suspect cyproterone acetate may be worsening their hair loss and are considering switching to injection monotherapy.