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GlossaryVasoconstrictors

substances that narrow blood vessels, reducing blood flow

Vasoconstrictors are substances that cause blood vessels to narrow, reducing blood flow and increasing blood pressure. They can be naturally occurring in the body, like adrenaline, or used in medications to treat conditions such as low blood pressure or to reduce blood flow during surgery.

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community Does nicotine have an effect on hair despite using finasteride?

in Research/Science 11 upvotes 2 months ago

Nicotine may negatively affect hair by reducing blood flow due to its vasoconstrictor properties, but its impact might be minimal. Finasteride users are advised to avoid nicotine to prevent potential hair loss issues.

community Could coffee contribute to hair loss?

in Research/Science 4 upvotes 4 years ago

Coffee may negatively impact hair health due to its vasoconstrictor effects, potential to increase DHT, and interference with nutrient absorption. There is no strong clinical evidence linking caffeine to hair loss or regrowth in humans, but moderation is advised.

community 2 years of dut, 1 year of loss 24m

in Progress Pictures 526 upvotes 3 months ago

The user experienced hair regrowth with dutasteride but later lost progress despite using minoxidil foam and dermastamping. Suggestions included reducing dermastamping frequency, conducting blood tests, and considering oral minoxidil or different brands of dutasteride.

community 13 months TOPICAL ONLY progress! (Diffuse thinner)

in Update 552 upvotes 5 months ago

The conversation is about a user's progress in treating diffuse hair thinning using a topical regimen including finasteride, minoxidil, ketoconazole, microneedling, saw palmetto, collagen, and vitamins, along with lifestyle changes. The user plans to switch from topical to oral finasteride for potentially better results.

community People who continue to lose hair on fin/dut, Are you on Nicotine?

in Research/Science 81 upvotes 11 months ago

Nicotine use, especially from vaping, may worsen hair shedding and reduce the effectiveness of finasteride and dutasteride. Quitting nicotine seems to improve hair health.

community Forgotten 'Total Revival' Stack

in Research/Science 42 upvotes 1 year ago

Cyclosporine A is discussed as a powerful hair growth stimulant, potentially more effective than minoxidil, but concerns about safety and side effects, including cancer risk, limit its use. The conversation highlights the need for further research and experimentation with topical application, despite its risks.

community Before and after? NO Fin/NO Minoxidil. Just DHT Blocking Shampoo&Microneedling

in Microneedling 54 upvotes 1 year ago

The user experienced hair thinning and used microneedling, DHT blocking shampoo, and Biotin DHT blocking oil to address it, avoiding finasteride and minoxidil unless necessary later. They reported mild improvement but received mixed feedback, with some suggesting other conditions or treatments like ciclopirox shampoo.

community High Nicotine use and Hair Loss

in Chat 91 upvotes 1 year ago

Heavy nicotine use can lead to hair thinning and loss, but quitting can reverse these effects. The user noticed significant hair regrowth after quitting vaping.

community 6 months on minoxidil shedding again

in Update 265 upvotes 2 months ago

A user experienced hair shedding after six months of using topical minoxidil and is considering adding finasteride to their routine. Many suggest that minoxidil alone is insufficient for stopping hair loss and recommend combining it with finasteride or dutasteride for better results.

community New drug for hair loss announced by Amplifica

in Research/Science 161 upvotes 3 years ago

Amplifica starting clinical trials for new hair loss drug. SCUBE3 protein discovered, stimulates hair growth, could be alternative to Minoxidil and Finasteride.

community hmi115 is coming. Prepare yourselves for what's coming

in Technology 107 upvotes 2 years ago

The conversation discusses HMI-115, a potential cure for hair loss. Users share mixed opinions, with some expressing skepticism and others sharing anecdotal evidence of its effectiveness, including photos of significant hair regrowth from a trial participant.

community Topical Minoxidil since April 2025. Finasteride since Sept 2025. Bald spot has gotten larger in area size and more noticeable in recent months. Trying to be patient but situation doesn’t seem to be resolving

in Minoxidil 8 upvotes 7 months ago

The user has been using topical Minoxidil since April 2025 and Finasteride since September 2025, but their bald spot has worsened. They are considering switching to oral Minoxidil and have been advised to be patient, see a dermatologist, and possibly try additional treatments like derma rolling.

community On the big 6 but very slow , needs acceleration

in Is this regrowth? 30 upvotes 11 months ago

The user is using a hair regrowth protocol including dutasteride, topical and oral minoxidil, dermarolling, ketoconazole shampoo, and tretinoin, but is experiencing slow progress and seeks advice for faster regrowth. Suggestions include quitting smoking, adjusting the regimen, and considering additional treatments like topical finasteride or RU58841.

community I can’t continue using oral minoxidil. I want to so badly though!

in Minoxidil 33 upvotes 1 year ago

The user experienced anxiety and heart pounding from oral minoxidil, despite its effectiveness, and switched back to topical minoxidil. After managing anxiety, they found oral minoxidil more effective, but side effects differ for each person.

community Quit vaping/smoking = 80% less loss

in Research/Science 235 upvotes 2 years ago

Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

community Dr Huberman - Cafeine when rubbed on the scalp can be as effective at times as minoxidil because it triggers 1GF-1

in Update 268 upvotes 3 years ago

Whether topical caffeine can be as effective for hair growth as minoxidil and finasteride, with various replies discussing the efficacy of these treatments and criticism of Dr. Huberman's research methods.

community Should I take creatine if Im on fin?

in Finasteride/Dutasteride 6 upvotes 11 months ago

Creatine is unlikely to worsen hair loss for those on finasteride, with no strong scientific evidence linking it to increased hair loss. Many users report no negative effects on hair while using creatine.

community One+ year 1mg Fin, Ketoconazole, and 3.75 Oral Min. I have DUPA. Switched from Topical to Oral Min.

in Progress Pictures 142 upvotes 3 years ago

A user's experience with hair loss treatments such as finasteride, ketoconazole, and oral minoxidil that have not yielded any results; other users suggest shaving the head or getting a wig, while others offer additional advice such as seeing a dermatologist, checking thyroid levels, switching to dutasteride and adding needling, and trying stemoxydine.

community Brotzu lotion update

in Update 89 upvotes 8 years ago

A new hair loss lotion by Dr. Brotzu, expected to regrow up to 5 years of lost hair, is set to be released by Fidia Farmaceutici. It claims to work like minoxidil and finasteride without side effects, but skepticism exists due to its classification as a cosmetic product.

community 1.5 Year - Bad Results (HT, FIN, MINO, PRP, etc)

in Progress Pictures 66 upvotes 1 year ago

A user shared their disappointing results after 1.5 years of hair treatments, including a hair transplant, finasteride, minoxidil, PRP, vegan shampoo, and more. They are considering switching to dutasteride, oral minoxidil, and improving their microneedling routine.

community Dental technician is convinced that he has found the cause of pattern hair loss

in Research/Science 316 upvotes 1 year ago

A dental technician claims malocclusion causes pattern hair loss due to poor scalp circulation. Users debate this, noting treatments like finasteride, minoxidil, and microneedling focus on DHT and blood flow.

community 7 months fin, 10 months min, 4 months dut. Should I continue?

in Is this regrowth? 159 upvotes 1 year ago

The user has been using finasteride for 7 months, minoxidil for 10 months, and dutasteride for 4 months with minimal results and is considering stopping treatment. Replies suggest continuing treatment, adding microneedling, and checking DHT levels.

community A hill on which I will die: The DHT itch absolutely exists

in Research/Science 210 upvotes 2 years ago

The DHT itch is linked to hair loss and persists despite finasteride use; switching to dutasteride helped alleviate the itch and promoted regrowth. Some users suggest seborrheic dermatitis as a cause and recommend treatments like medicated shampoos, vitamin D, and minoxidil.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 677 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community This is the best time in human history to be fighting hair loss

in Treatment 194 upvotes 3 years ago

This conversation discusses the advancements in treatments for hair loss, including finasteride, dutasteride, minoxidil and new promising treatments such as pyrilutamide and verteporfin. Other treatments discussed were taking minoxidil orally, tretinoin to turn non-responders into responders and microneedling to further boost growth.

community 4.5 months/ Fin+Niz+Keto+Vitamins+Derm+Cold Water only washes

in Progress Pictures 618 upvotes 4 years ago

User achieved hair regrowth in 4.5 months using Fin, Min, Nizoral, vitamins, dermarolling, and cold water washes. Cold water washes improved scalp health, but unsure if significant contributor to regrowth.

community Switching from Topical to Oral Minoxidil.

in Minoxidil 397 upvotes 11 months ago

Switching from topical to oral minoxidil for hair loss, with plans to use it alongside dutasteride. Users report mixed experiences, including increased body hair, potential heart-related side effects, and varying hair regrowth.

community My hair stopped falling out after I quit smoking

in Update 60 upvotes 1 year ago

Quitting smoking led to reduced hair loss for the original poster, who also used finasteride and topical minoxidil. Other users shared mixed experiences with smoking and hair loss, with some noticing improvements after quitting and others seeing no change.

community 10months on minoxidil as an “ok responder”

in Progress Pictures 205 upvotes 8 months ago

The user added topical minoxidil to their finasteride regimen, resulting in healthier hair and some regrowth, especially after quitting nicotine. They experienced minimal shedding and noted improvements in hairline density, finding the treatment mostly preventative.

community HMI 115 Phase 2 - Leaked pics from Discord

in Research/Science 362 upvotes 2 years ago

The conversation discusses HMI 115, a new hair loss treatment with promising results, showing a significant increase in hair density after two months. Some users are skeptical, while others are hopeful for its release and potential affordability.