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      community Trestolone (MENT) as a nuclear treatment

      in Treatment  99 upvotes 3 years ago
      Experimenting with trestolone as a treatment for hair loss in an attempt to avoid DHT-related treatments such as finasteride and dutasteride, and discussing the potential effects of its receptor selectivity on the androgen receptors in the scalp.

      community Study: You can safely conceive on Dutasteride

      in Research/Science  95 upvotes 1 year ago
      Dutasteride is considered safe for conception, with semen concentrations being too low to cause harm. Users discuss switching between dutasteride and finasteride, with some experiencing side effects like acne and heart issues, and advice is given to maintain a consistent treatment regimen.

      community Will taking DHT blockers at 17 prevent FULL facial bone growth?

      in Basic Questions  153 upvotes 1 month ago
      A 17-year-old is concerned that taking finasteride might affect facial bone growth and is considering switching to topical finasteride due to its reduced systemic effects. They are also using oral minoxidil and exploring other hair loss treatments like microneedling and ketoconazole shampoo.

      community progress pics (HRT, fin, min, microneedling) (35, trans non-binary)

      in Transgender  11 upvotes 1 year ago
      A non-binary transfeminine person experienced significant hair regrowth after starting finasteride, minoxidil, microneedling, and hormone replacement therapy with estradiol. They encourage trans individuals concerned about hair loss to consider estrogen as it has greatly improved their hair condition.

      community Why was fluridil abandoned and never made past phase 2?

      in Chat  4 upvotes 4 years ago
      Fluridil was abandoned due to its weak effectiveness and low binding affinity to the androgen receptor, making it less competitive against DHT and testosterone. Users discuss its limited results compared to other treatments like pyrilutamide and RU58841.

      community [Research/Science] What's the General Consensus On Pyrilutamide So Far?

      in Research/Science  8 upvotes 3 years ago
      Pyrilutamide is considered to work for hair loss but less effectively than expected, similar to RU58841, and may cause side effects like chest tightness and sexual issues. It's unclear if it's suitable for diffuse thinners, and one user cannot use minoxidil or finasteride due to side effects and personal circumstances.

      community Brutal... RU58841 , is that true ?

      in Update  162 upvotes 1 year ago
      The conversation discusses hair loss treatments, specifically Minoxidil, finasteride, and RU58841. Concerns are raised about the lack of studies on RU58841 and its potential effects.

      community Having androgen receptor density and sensitivity at wrong f*ing place

      in Satire  7 upvotes 1 year ago
      The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

      community Dutasteride and it’s effect on Erections

      in General  105 upvotes 11 months ago
      The user switched from finasteride to dutasteride and initially experienced increased energy and libido but is now facing erection issues. They are unsure if it's due to performance anxiety and are seeking advice while wanting to continue dutasteride for its benefits.

      community Finasteride FTM experiences after being on T for 2+ years?

      in Transgender  6 upvotes 2 years ago
      People are discussing experiences with finasteride for hair loss after being on testosterone for over two years. Users report varying results, with some experiencing regrowth and no side effects, while others emphasize the importance of starting treatment early to prevent further hair loss.

      community Anagen is now selling pyrilutamide

      in Product  138 upvotes 3 years ago
      Pyrilutamide, a potential hair loss treatment that has recently been released for sale, and is thought to have similar efficacy to Dutasteride without side effects. It was discussed in terms of its effectiveness compared to Finasteride, its use by females, and whether it can be safely mixed with RU58841.

      community Finasteride to Dutasteride 6 months teenager 17M AMA

      in Progress Pictures  313 upvotes 1 year ago
      A 17-year-old is using oral dutasteride, finasteride, and topical minoxidil for hair loss, with plans to increase dutasteride and consider surgery. They report significant regrowth but are worried about side effects and the effects of blocking DHT at a young age.

      community Oral fin -> topical, shedding like hell

      in Finasteride/Dutasteride  19 upvotes 1 month ago
      The user experienced severe side effects from oral finasteride, including sexual dysfunction and mental health issues, and switched to topical finasteride, which led to significant hair shedding. They are considering other treatments like RU58841 or topical dutasteride and are advised to check testosterone levels and address potential underlying health issues.

      community DHEA, the culprit behind DUPA ? Read this!

      in Research/Science  19 upvotes 2 years ago
      High DHEA levels may contribute to hair loss by increasing DHT in hair follicles, potentially explaining why finasteride is ineffective for some. Treatments like high-dose dutasteride and RU58841 are suggested, but the underlying cause, such as adrenal issues, should be investigated.

      community The hardest hair protocol ever!

      in Research/Science  10 upvotes 3 years ago
      The user is using RU58841, finasteride, dutasteride, and minoxidil to slow down aggressive hair loss but is still experiencing hair shedding due to high testosterone levels. They plan to use ostarine to lower testosterone and prevent hair loss while maintaining muscle mass, and will continue using the other treatments.

      community Is this broscience? From More Plates, More Dates

      in Research/Science  21 upvotes 2 years ago
      The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

      community PCOS Hair Loss: What’s Helped Me (and What Didn’t)

      in Treatment  11 upvotes 9 months ago
      OP shares their experience with PCOS-related hair loss, highlighting that addressing vitamin D and ferritin deficiencies, managing hormones with spironolactone, and using gentle hair care products helped improve their condition. They advise against relying on "miracle" hair oils and emphasize the importance of medical evaluation and a combined approach to treatment.

      community Tretinoin for some men(not all) can cause non-telogen effluvium hair loss

      in Research/Science  5 upvotes 11 months ago
      Tretinoin can cause non-telogen hair loss in some men by inducing catagen-like changes in hair follicles and through retinoid toxicity, especially when used with minoxidil. Some users report hair loss even when using retinoids on the face, while others experience benefits when combined with treatments like finasteride and minoxidil.

      community Mechanism of action of alfatradiol (17 alpha estradiol)

      in Research/Science  5 upvotes 2 years ago
      The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

      community Dutasteride , bloodwork and dht.

      in Finasteride/Dutasteride  16 upvotes 2 years ago
      The user reported high testosterone and estradiol levels within range, but unexpectedly high DHT levels after using finasteride and dutasteride for hair loss. Another person suggested the dutasteride might be fake or a bad batch and recommended using the branded Avodart.