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A new topical medication, Clascoterone, shows promise for hair loss, improving hair count significantly. Trials for Breezula are ending, but sign-ups for PP405 trials are available for 2026.

OP is considering making a 5% topical Clascoterone (Breezula) for hair loss, as they use Minoxidil but can't use Finasteride due to side effects. They seek advice on creating the topical safely, possibly with help from a trained chemist.

The conversation is about a user's 5-month progress using topical Minoxidil (5%) and Finasteride (0.1%) twice daily, along with derma stamping, improved Vitamin D levels, and increased protein intake for hair regrowth. The user is considering dutasteride if progress plateaus and uses a sulfate and paraben-free shampoo.

The user is experiencing hair loss without a family history and suspects stress or telogen effluvium (TE) as the cause, despite using finasteride without results. Others suggest stress, vitamin deficiencies, or other conditions could be factors, and some mention that balding can occur without a family history.

The user is concerned about hair loss and is hesitant to use treatments like finasteride and minoxidil due to potential side effects. Another user suggests gradually introducing finasteride to minimize side effects and maximize results.

The conversation discusses using a 0.03% topical Dutasteride solution for hair loss, as it may be more effective than Finasteride with fewer systemic side effects. OP plans to apply it daily for 100 days, then reduce frequency, due to past negative cognitive effects from oral treatments.

The user is considering stopping topical minoxidil due to health risks and inconvenience, while continuing oral minoxidil, dutasteride, and vitamins. Others suggest that oral minoxidil carries more risk, and results from treatments may take 3-6 months to appear.

A 30-year-old is using rosemary oil and starting microneedling to address weakening hair, seeking advice on frequency and combination. Another user suggests using finasteride and minoxidil for better results, criticizing the effectiveness of rosemary oil and emphasizing the importance of understanding hair loss causes.

Oleic acid, microneedling, and emu oil are discussed as potential hair growth treatments, with some users expressing skepticism about their effectiveness. Minoxidil and finasteride are recommended as current reliable treatments until more proven solutions are available.

Results for PP405 are expected next year, with concerns about its pricing and potential black market availability. Some users believe it may be slightly more effective than finasteride and dutasteride, and combining it with treatments like minoxidil and microneedling could be beneficial.

The user did not respond to minoxidil and is considering using tretinoin to improve results. They also explored finasteride, microneedling, adapalene, red light therapy, and oral minoxidil as potential treatments.

The user is considering switching from Minoxidil to dutasteride for hair loss treatment but is concerned about the potential for increased shedding. They are seeking advice on whether to wait for the current shedding phase to subside before starting dutasteride.

A 22-year-old male experienced significant hair regrowth after five months using 1mg finasteride and 5mg minoxidil, with plans to switch to dutasteride. He reported emotional changes and thicker eyebrows and eyelashes as side effects.

The user experienced significant hair improvement after 8.5 months on finasteride and 4 months on 2.5mg oral minoxidil, with recent addition of dutasteride. Bald spots have disappeared, and hair looks normal now.

The user experienced scalp irritation from a Finasteride and Minoxidil spray and serum. They are considering switching to foam, oral treatments, or another provider.

The user is using oral finasteride and minoxidil 2mg for hair loss and is considering adding a scalp serum with caffeine, but is concerned it might interfere with minoxidil. They seek advice on maintaining a hydrated, non-oily scalp.

A user has been using finasteride and minoxidil for 4-5 months, along with D3 and Biotin supplements, and is seeking feedback on hair regrowth progress. Responses are mixed, with some noticing slight improvements in density and thickness, while others see no change.

A user experienced a loss of libido and anhedonia after severe dietary restriction while on Finasteride and Minoxidil for hair loss. They are considering reducing the Finasteride dose or taking a break to see if symptoms improve.

The user has been using finasteride inconsistently for 2 years and minoxidil for 6 months without seeing hair growth. They are considering switching to dutasteride and restarting minoxidil to address thinning at the right temple, with advice suggesting consistent use for better results.

DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

The user is using a hair regrowth treatment plan that includes finasteride, microneedling, minoxidil foam, ketoconazole shampoo, and piroctone olamine shampoo. They are seeking advice on the effectiveness of their regimen and dosage of finasteride, and are curious about others' experiences with piroctone olamine.

A 26-year-old male experiencing hair knotting and breakage has been using finasteride for 7 months, noticing some improvement. He uses keto shampoo, conditioner, leave-in conditioner, and argan oil, and is considering adding minoxidil and vitamins for hair strength.

A user is considering using both oral and topical finasteride for hair loss, despite having elevated liver enzymes. They currently use a topical spray with finasteride and minoxidil and are seeking advice on whether using both forms is advisable.

Some users experienced erectile dysfunction with finasteride but not with dutasteride, while others had issues with both. Individual reactions vary, with some reporting improved mood and hair growth on dutasteride.

Tretinoin may enhance minoxidil absorption, potentially improving hair regrowth when combined with microneedling. Users discuss various treatments like minoxidil, finasteride, dutasteride, and microneedling, with mixed results and concerns about side effects and scarring.

Some people may not respond to topical minoxidil due to low SULT1A1 enzyme activity, but oral minoxidil can be effective. Tretinoin may enhance minoxidil's effectiveness, and some users prefer oral minoxidil despite side effects.

A 41-year-old has been using finasteride for 16 years with great results but is now experiencing temporal hair loss. Suggestions include switching to dutasteride, adding oral minoxidil, and considering a combination of treatments, while noting that supplements and weightlifting likely don't interfere with finasteride's effectiveness.

The conversation is about making homemade topical finasteride by crushing pills and mixing them with ethanol and propylene glycol or minoxidil. Users discuss sourcing options and share experiences with DIY solutions.

White spots on a bald scalp, likely tinea versicolor, can be treated with ketoconazole or selenium sulfide shampoos like Selsun Blue. Consulting a dermatologist is recommended for proper diagnosis and treatment.

The user reduced serum DHT by 60% using Advanced Trichology's natural DHT blocker but saw no improvement in hair loss. They are considering switching to finasteride due to its proven effectiveness in inhibiting scalp DHT.