community Pp405 - lowkey kinda bad results
PP405 increased hair density by 20% in 31% of participants, but results are considered underwhelming. Minoxidil and finasteride are seen as more effective treatments.
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community What kind of balding is this?
A 34-year-old male is experiencing hair loss on the sides of his head, with inflammation and itchiness, while the top remains thick. He is using topical dutasteride and keto shampoo to address the issue.
community 22M Dut+min+microneedling. Diffuse AGA.
A 22-year-old male uses dutasteride, a serum with 10% minoxidil and 0.5% finasteride, and microneedling for diffuse androgenetic alopecia. Progress pictures show changes from July 2025 to February 2026.
community Saw Palmetto/Pumkin seed gives basically same results as Fin
A user reported that Procerin, containing Saw Palmetto and Pumpkin seed oil, provided similar hair thickening results as finasteride but with milder side effects. They experienced reduced libido and watery ejaculations but are adjusting the dose to minimize these effects.
community Can nizoral cause hair to shed with different thicknesses/lengths or is that just miniaturization?
The user is experiencing hair shedding of different thicknesses/lengths and is using Nizoral, ciclopirox, and pyrithione zinc conditioner. They are concerned whether the shedding is due to these treatments, miniaturization, or their low-calorie diet.
community If PP405 goes systemic this would be quite catastrophic
Concerns about the potential systemic effects and safety of PP405 for hair loss, with discussions on its comparison to existing treatments like finasteride and minoxidil. Users express skepticism about untested research chemicals and emphasize the importance of clinical trials to ensure safety and efficacy.
community No side effects on pyrilutamide / KX-826 so far
User TopBack56 and friends tried pyrilutamide (KX-826) for hair loss without experiencing negative side effects. They observed fine vellus hairs but no thick hair growth yet, and plan to add GT20029 to their regime after safety trials.
community PP405 (Everychem 3HP) Users - Assemble and share your story!
Users discussed the effectiveness of Everychem's solution, similar to PP405, with some reporting improved hair thickness and new growth. Concerns were raised about safety and the legitimacy of the product, with some users advising against purchasing research chemicals.
community IGE Hair Loss and Miniaturization
A 23-year-old male is experiencing diffuse hair loss and miniaturization, possibly due to high IGE levels after using tofacitinib. He seeks advice and has not yet consulted a dermatologist.
community Kintor Pharma Announced Successful Dosing of the First Patient for Acne Vulgaris Phase II Clinical Trial of KX-826
Kintor Pharma successfully dosed the first patient in a Phase II trial for KX-826 for acne vulgaris. Users are more interested in results for male pattern baldness (MPB).
community Prolonged shedding over last 15 months
The user has been experiencing prolonged hair shedding despite using Dutasteride, Minoxidil, and topical Finasteride, with blood tests showing high free testosterone and low SHBG. Suggestions include adjusting Minoxidil dosage, considering topical anti-androgens like RU58841, and addressing metabolic factors to increase SHBG.
community What treatment should I take? and is it really bad?
OP is experiencing significant hair loss despite GFC and PRP treatments and has abnormal lab results. They are advised to consult a hair-focused dermatologist for further evaluation.
community 4.5 months of Dut/5% topical min
OP saw significant hair growth after starting scalp exfoliation and using 5% topical minoxidil for 4.5 months, along with microneedling initially. Users discussed the benefits of exfoliation and inquired about experiences with finasteride and dutasteride.
community Progress(?) update photos 2.5 months of pyrilutamide and minoxidil
The conversation discusses hair regrowth progress after 2.5 months using pyrilutamide and minoxidil. Participants note visible improvement in a short time.
community VDPHL01 works really quickly .. apparently?
VDPHL01 shows faster and stronger hair growth compared to standard minoxidil, with no major side effects reported. Users discuss combining it with other treatments like dutasteride and finasteride for better results, while expressing skepticism about the effectiveness of PP405.
community Actifolic RU58841 and others Scam?
Actifolic's RU58841 and Pyri products are perceived as ineffective, with users reporting no side effects or improvements, suggesting possible quality issues. Users recommend alternative sources and emphasize the importance of timing when using RU58841 with Minoxidil.
community P-1075: a BETTER version of Minoxidil
P-1075 is a more potent hair growth agent than Minoxidil, but it poses significant heart risks, making it unsafe for use. Despite promising results in macaques, concerns about its cardiotoxicity in rats have halted its development.
community 6 Months on Minoxidil: Bald Spots Still Visible, Seeking Advice Before Dermatologist Visit
The user has been using minoxidil for 6 months and has seen improvements but still has bald spots. They plan to consult a dermatologist to address their concerns.
community RU58841 vehicle penetration (Study for minoxidil)
The user mixes their own RU58841 solution and found that increasing the ethanol content improved absorption and reduced scalp itching. A study on minoxidil showed that penetration increased with higher ethanol concentrations, reaching maximum penetration at 90% ethanol.
community Peptide Therapy -> GHK-CU, ZN-Thumulin, PTD-DBM
The conversation is about the use of peptide therapies for hair loss, specifically GHK-CU, ZN-Thymulin, and PTD-DBM. The user is seeking feedback on the effectiveness of these treatments from those who have tried them.
community Mystery hair loss and colour change
The user is experiencing severe hair loss and color change despite low testosterone levels and healthy lifestyle changes. They have tried ketoconazole shampoo and consulted a dermatologist, who found no scalp issues but suggested using Toppik for coverage.
community Fin EOD, topical min 1x day, keto 2x a week, Vitamin D3 + Zinq - Some progress, i hope for more. Temples gotton better too, lots of babyhairs everywhere.
The user reports progress in hair regrowth using finasteride every other day, topical minoxidil once daily, ketoconazole twice a week, and Vitamin D3 with zinc. They note improvement in temple areas and the appearance of baby hairs.
community Finasteride topical formulation (pharmacy vs stemoxydine)
Hair loss discussion includes treatments like hinoki tree oil and procyanidin b2. Experiences and effectiveness of these treatments are shared.
community 5 months post op in 5 days 4500 graphs - hair is starting to fill out nicely 🥹 low dosage RU .25ml on native hairs daily ( avoiding transplant hair ) prp once a month. No other medications and ALL hair loss has halted - Next update will post up between 6-8 months.
The user "Curious_Conflict_959" shared a progress picture of their hair transplant after 5 months. They used a low dosage of RU on native hairs and had PRP treatments. All hair loss has stopped.
community I tried mixing 3 grams RU58841 into 60ml minoxidil 5% solution and shook for 5 minutes and I can still see tiny crystals floating around like a snow globe when I shine a torch in the bottle
OP mixed RU58841 with minoxidil and initially saw crystals, but realized they were bubbles. They asked for advice on application frequency for a 5% solution.
community Topical Dutasteride Recommended doses and concentrations with microneedling?
Topical dutasteride with microneedling is effective for androgenetic alopecia, improving hair thickness and density. Further research is needed to confirm long-term efficacy.
community 2 months progress?? on fin 1mg everyday and derma rolling .5 once a week.
A user shared their 2-month progress on finasteride 1mg daily and weekly derma rolling, showing noticeable hair regrowth. Replies confirm visible improvement, though some attribute it partially to lighting.
community Autoimmune issue?
The user experienced severe hair loss, itchy scalp, and skin issues after trying no-shampoo, and wonders if it's male pattern baldness or an immune issue. They have a history of eczema, dermatitis, and jock itch, and have tried various treatments like coconut oil, peppermint, pumpkin seed, and onion.
community Don’t Get Too Hyped About PP405. We've Seen This Movie Before.
PP405 is a new hair loss treatment showing early promise with a 20% hair density increase, but skepticism exists due to past failures of similar treatments like Pyrilutamide, RU58841, and Bimatoprost. Users debate its potential effectiveness, with some hopeful due to Google's involvement, while others urge caution without more evidence.
community How did you all stop the itching that occurs where you are balding?
People discussed solutions for scalp itching related to hair loss, with treatments including finasteride, dutasteride, ketoconazole shampoo, and Alpecin Hybrid shampoo. Some users found relief by adjusting dosages of finasteride or switching to dutasteride, while others recommended specific shampoos or prescription options like olux foam.