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      learn KY19382

      compound that activates Wnt/β-catenin to promote hair regrowth and create new hair follicles

      learn Valproic acid

      an anticonvulsant repurposed for hair loss via histone inhibition

      learn Tofacitinib

      a JAK inhibitor for alopecia areata and other autoimmune conditions

      learn Bimatoprost

      a synthetic prostamide used to treat eyelashes also shows promise for stimulating hair growth on scalp

    Research

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      community Hair loss research is a money grab

      in Chat  227 upvotes 5 months ago
      Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community DHT and 5AR respect post, it's importance within the brain

      in Research/Science  111 upvotes 2 years ago
      The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

      community Creatine is the opposite of minoxidil !

      in Research/Science  321 upvotes 5 months ago
      Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

      community How is dht not beneficial to you?

      in Finasteride/Dutasteride  111 upvotes 2 months ago
      DHT is important for sexual function and mood, but finasteride and dutasteride can reduce DHT, causing side effects like reduced libido and erectile dysfunction. These treatments are effective for hair loss, but their impact on DHT leads to debate.