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Discoid lupus erythematosus involves immune activation and fibrosis around hair follicles, with shared pathways across humans, dogs, and mice, suggesting potential treatments for both humans and animals.

Potential therapeutic targets for scarring hair loss are identified.

Chemokine signaling is important for hair development.

CXCL12+ fibroblasts help recruit neutrophils to fight skin infections.

Plerixafor may help treat pigmentation disorders by promoting skin repigmentation.