research CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata 64 citations , July 2016 in “Journal of Immunology” Blocking the CXCR3 receptor reduces T cell accumulation in the skin and prevents hair loss in mice.
research PD-1+CXCR5−CD4+T cells are correlated with the severity of systemic lupus erythematosus 71 citations , May 2019 in “Rheumatology” Tph cells are linked to the severity of systemic lupus erythematosus.
research Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration October 2025 in “Cell Reports” Regulatory T cells help hair growth by using the Cxcr4-Cxcl12 pathway.
research Cross-species comparative spatial transcriptomics of hair follicle-T cell interactions identifies conserved drivers of cutaneous lupus erythematosus skin disease and associated hair loss July 2026 in “Nature Communications” CXCR3+ T cells and B cells drive skin disease and hair loss in lupus, with potential targets identified for treatment.
research Alopecia areata possibly induced by autoimmune reaction in a patient with human T‐cell lymphotropic virus‐1‐associated myelopathy 6 citations , May 2013 in “The Journal of Dermatology” Autoimmune reactions may cause both alopecia areata and HAM.