March 2026 in “Food Science and Biotechnology” The study investigates the effects of blue honeysuckle fruit aqueous extraction (BHAE) and its major component, cyanidin-3-O-glucoside (C3G), on hair growth. BHAE was shown to enhance the proliferation of human hair follicle dermal papilla cells and activate the β-catenin signaling pathway. In C57BL/6 mice, oral administration of BHAE accelerated the transition from the telogen to anagen phase, increasing hair follicle size and number. Molecular analysis revealed that β-catenin activation upregulated growth factors and cyclins. C3G replicated these effects, suggesting that BHAE, rich in C3G, promotes hair growth by activating β-catenin signaling, highlighting its potential as a functional food or cosmeceutical for hair regeneration.
28 citations
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May 2000 in “Proceedings of the National Academy of Sciences” The Walleye dermal sarcoma virus cyclin causes excessive skin cell growth in mice.
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92 citations
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November 2006 in “Proceedings of the National Academy of Sciences of the United States of America” BMP signaling controls hair follicle size and cell growth by affecting cell cycle genes.
30 citations
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April 2017 in “European Journal of Cell Biology” CIP/KIP proteins help stop cell division and support hair growth.