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GlossaryCytokeratins

fibrous proteins providing structural support in epithelial cells

Cytokeratins, also known as keratin proteins or CKs, are a group of fibrous structural proteins that form the intermediate filaments in epithelial cells. They provide mechanical support and help maintain the integrity of cells and tissues. In a clinical context, cytokeratins are often used as biomarkers in the diagnosis and study of various cancers, as their expression patterns can indicate the type and origin of a tumor.

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research Different keratin polypeptides in epidermis and other epithelia of human skin: a specific cytokeratin of molecular weight 46,000 in epithelia of the pilosebaceous tract and basal cell epitheliomas.

277 citations , October 1982 in “The Journal of Cell Biology”

Basal-cell epitheliomas and the pilosebaceous tract share a unique keratin, distinguishing them from other skin areas.

research Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues. I. Human and bovine hair follicles

248 citations , April 1988 in “Differentiation”

Human and bovine hair follicles have distinct cytokeratins specific to hair-forming cells.

research Cytokeratins as Markers of Follicular Differentiation

121 citations , December 2001 in “American Journal of Dermatopathology”

TB and BCC tumors show similar follicular differentiation patterns.

research Immunohistochemical localization of cytokeratins and involucrin in calcifying epithelioma: comparative studies with normal skin

49 citations , July 2006 in “British Journal of Dermatology”

Calcifying epithelioma cells can differentiate into hair cortex and outer root sheath.

research A Novel Type II Cytokeratin, mK6irs, is Expressed in the Huxley and Henle Layers of the Mouse Inner Root Sheath

45 citations , March 2001 in “Journal of Investigative Dermatology”

A new protein, mK6irs, is found in specific hair layers and may help understand hair growth and diseases.

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