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GlossaryDesmosomes

specialized cell structures that glue adjacent cells together

Desmosomes are specialized structures in the cell membrane that act like glue, holding cells together, particularly in tissues that experience a lot of stress, such as skin and heart muscle. They are composed of proteins that link the cytoskeletons of adjacent cells, providing mechanical strength and stability to tissues.

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research Immunolocalization of Junctional Proteins in Human Hairs Indicates That the Membrane Complex Stabilizes the Inner Root Sheath While Desmosomes Contact the Companion Layer Through Specific Keratins

12 citations , January 2013 in “Acta Histochemica”

Junctional proteins stabilize the inner root sheath and connect the companion layer in human hair.

research Desmosomes in Developing Human Epidermis

11 citations , January 2010 in “Dermatology Research and Practice”

Desmosomes are crucial for human skin development, increasing in density as the skin matures.

research Using the Frog Epidermis to Uncover Desmosome Function and Regulation in the Developing Embryo

January 2018 in “VCU Scholars Compass (Virginia Commonwealth University)”

Desmosomes are crucial for skin and heart development, and JNK may help regulate them.

research Patterns of Desmocollin Synthesis in Human Epithelia: Immunolocalization of Desmocollins 1 and 3 in Special Epithelia and Cultured Cells

96 citations , September 1996 in “PubMed”

Desmocollin 1 and 3 have distinct patterns in human tissues, with Dsc1 in specific skin and hair layers and Dsc3 in various epithelial layers.

research Increased Expression of Keratin 16 Causes Anomalies in Cytoarchitecture and Keratinization in Transgenic Mouse Skin

94 citations , October 1994 in “The Journal of Cell Biology”

Too much keratin 16 in mice skin causes abnormal skin thickening and structure.

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