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research Pathogenic Mechanisms and Mechanism‐Directed Therapies for Androgenetic Alopecia: Current Understanding and Future Directions

January 2025 in “Dermatologic Therapy”

Targeting multiple pathways may improve treatments for androgenetic alopecia.

research Finasteride for female androgenetic alopecia

51 citations , October 2002 in “British Journal of Dermatology”

Finasteride increases hair density in female androgenetic alopecia, but individual results may vary.

research Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways

1 citations , May 2017 in “InTech eBooks”

Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.

research The role of prostaglandins in androgenetic alopecia

4 citations , February 2021 in “International Journal of Dermatology”

Prostaglandins may contribute to male hair loss; targeting them could help treat it.

research Advancements in Bioactive Compounds and Therapeutic Agents for Alopecia: Trends and Future Perspectives

December 2025 in “Cosmetics”

New treatments for alopecia show promise in restoring hair growth by targeting immune and hormonal factors.

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community Dental technician is convinced that he has found the cause of pattern hair loss

in Research/Science 314 upvotes 2 years ago

A dental technician claims malocclusion causes pattern hair loss due to poor scalp circulation. Users debate this, noting treatments like finasteride, minoxidil, and microneedling focus on DHT and blood flow.

community The "DHT" itch myth - it's more complicated

in Product 6 upvotes 3 years ago

A user found that scalp itch might be linked to inflammation rather than DHT alone and noticed hair improvement with certain cancer drugs. They also discovered that black seed oil relieved their scalp itch and are experimenting with a mix of essential oils for dry scalp, questioning if oils affect minoxidil absorption.

community Opinions on Scalp fibrosis and DHT?

in Research/Science 9 upvotes 4 years ago

The conversation discusses the theory that scalp fibrosis contributes to male pattern baldness (MPB) by increasing DHT concentration, and mentions treatments like Minoxidil. The user seeks opinions on the theory and the effectiveness of scalp massages.

community Research: Minoxidil grows hair by suppressing androgen activity (DHT) in hair follicles.

in Minoxidil 43 upvotes 6 years ago

Minoxidil may suppress androgen activity in hair follicles, potentially aiding in hair growth and prostate cancer treatment. Users discuss the effectiveness of minoxidil and finasteride for hair maintenance and regrowth, with some preferring topical applications over oral due to safety concerns.

community Stumbled on some research

in Research/Science 6 upvotes 5 years ago

Elevated PGD2 levels in bald scalp tissue may contribute to hair loss, and treatments like castor oil, finasteride, and minoxidil are discussed as potential solutions. Some users explore alternatives like oral castor oil and cetirizine for those who cannot use finasteride.

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