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GlossaryDiffuse Alopecia

widespread hair thinning across the entire scalp

Diffuse Alopecia, also known as Diffuse Hair Loss or Diffuse Thinning, is a condition characterized by a widespread thinning of hair across the entire scalp rather than in localized patches. This type of hair loss can be caused by various factors, including nutritional deficiencies, hormonal imbalances, stress, or underlying medical conditions, and it typically does not result in scarring of the scalp.

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Research

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research Diffuse scalp alopecia in a middle-aged patient

2 citations , June 2013 in “Clinical and Experimental Dermatology”

Thorough evaluation is crucial for understanding diffuse scalp hair loss.

research Iron deficiency and diffuse nonscarring scalp alopecia in women: More pieces to the puzzle

30 citations , October 2010 in “Journal of The American Academy of Dermatology”

The conclusion suggests a possible link between iron levels and hair health in women, recommending further research on iron supplementation for hair loss.

research Diffuse alopecia of the scalp in borderline-lepromatous leprosy in an Indian patient

2 citations , January 1997 in “Leprosy Review”

A neglected leprosy treatment led to rare scalp hair loss in an Indian woman, which improved with proper medication.

research Diffuse neurofibroma of the scalp with alopecia areata as the initial presentation: a case report

January 2014 in “International Journal of Dermatology and Venereology”

A man with hair loss and a scalp lump was diagnosed with a diffuse neurofibroma but chose not to have surgery.

research Localized Acquired Perforating Dermatosis on Scalp Presented With Acute and Diffuse Total Alopecia

January 2026 in “International Journal of Dermatology”

Treatment improved scalp conditions and hair loss with no recurrence after 1 year.

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Community Join

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community Androgenic alopecia exclusively on the vertex of the scalp

in Chat 6 upvotes 2 years ago

A user experienced androgenic alopecia starting at the vertex without frontal hairline recession and is seeking information on this pattern. Another user noted that vertex or diffuse hair loss is common among men.

community DUPA / APHK discussion ( Diffuse unpatterned alopecia / Acquired Progressive Hair Kinkering )

in Treatment 4 upvotes 7 years ago

The user discusses their experience with diffuse unpatterned alopecia and acquired progressive hair kinkering, noting improvements with treatments including biotin, pantothenic acid, finasteride, ketoconazole, and zinc pyrithione shampoo. They report thicker, healthier hair and improved scalp condition, attributing success mainly to biotin, pantothenic acid, and finasteride.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Effectiveness of Dutasteride 0.5mg: Scalp vs Follicle DHT Reduction for AGA

in Treatments 97 upvotes 9 months ago

Dutasteride 0.5 mg significantly reduces both scalp and hair follicle DHT, with a greater reduction in hair follicle DHT. The discussion questions which reduction is more important for androgenetic alopecia and diffuse thinning.

community Diffuse Alopecia

in Female 5 upvotes 5 years ago

A 19-year-old female with Diffuse Alopecia was advised by a dermatologist to use vitamin supplements, a hair serum, and antifungal drops, leading to some improvement. Other users suggested treatments like minoxidil, microneedling, and consulting a different dermatologist for further advice.

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