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GlossaryDihydrotestosterone Synthesis

enzyme 5-alpha-reductase converts testosterone into potent androgen DHT

Dihydrotestosterone (DHT) synthesis is the process by which the enzyme 5-alpha-reductase converts testosterone into DHT, a more potent androgen hormone. DHT plays a crucial role in the development of male characteristics and is also implicated in conditions like male pattern baldness and prostate enlargement.

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Research

5 / 1000+ results

research Neo-synthesis of estrogenic or androgenic neurosteroids determine whether long-term potentiation or depression is induced in hippocampus of male rat

32 citations , October 2015 in “Frontiers in Cellular Neuroscience”

DHT is needed for long-term depression, while E2 is needed for full long-term potentiation in male rat brains.

research Androgen Receptors and Androgen-Dependent Initiation of Protein Synthesis in the Prostate

59 citations , January 1976 in “Vitamins and hormones”

Prostate cells have proteins that bind to specific hormones, which can increase protein production when activated by these hormones.

research Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts

57 citations , April 2009 in “The Journal of Steroid Biochemistry and Molecular Biology”

Steroidogenesis inhibitors change but don't stop androgen production in prostate cancer.

Dihydrotestosterone Stimulates 5α-Reductase Activity in Pubic Skin Fibroblasts

research Dihydrotestosterone Stimulates 5a-Reductase Activity in Pubic Skin Fibroblasts*

57 citations , February 1983 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.

Inhibition of Rat 5α-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract of Quercus Acutissima Cortex

research Inhibition of Rat 5α-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract ofQuercus acutissimaCortex

37 citations , January 2015 in “Evidence-based Complementary and Alternative Medicine”

An extract from Quercus acutissima bark was found to reduce sebum production and block an enzyme linked to acne.

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Community Join

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community Why is dht bad for scalp hair but good for hair on the rest of body?

in Satire 109 upvotes 3 years ago

The conversation discusses why DHT (dihydrotestosterone) negatively affects scalp hair but promotes growth elsewhere on the body. Various opinions include genetic predispositions, differences in hair follicle reactions to DHT, and the potential role of Omega-3 in reducing inflammation and promoting hair health.

community I'm conducting the biggest study on Creatine Monohydrate's effects on Hair Health

in Research/Science 286 upvotes 8 months ago

Creatine monohydrate's potential link to hair loss, with mixed opinions on its effects. Treatments like minoxidil, finasteride, and RU58841 are discussed.

community Creatine Doesn’t Cause Hair Loss: Stop the BS

in Research/Science 140 upvotes 9 months ago

Creatine does not cause hair loss, despite many users reporting personal experiences of hair shedding. Scientific evidence shows no link between creatine and increased hair loss or hormone changes.

community Summary of Procapil video by Haircafe

in Minoxidil 2 upvotes 1 year ago

Procapil is marketed as a natural hair loss treatment but lacks strong evidence and is industry-biased. Minoxidil and Finasteride are the only FDA-approved treatments for androgenetic alopecia.

community risks with finasteride and dutasteride

in Research/Science 141 upvotes 1 year ago

Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

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