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research Niacinamide Down-Regulates the Expression of DKK-1 and Protects Cells from Oxidative Stress in Cultured Human Dermal Papilla Cells

1 citations , October 2021 in “Clinical, Cosmetic and Investigational Dermatology”

Vitamin B3 may help prevent hair loss and promote hair growth by protecting scalp cells from stress and reducing hair growth-blocking proteins.

research Dickkopf-1 Expression in Androgenetic Alopecia and Alopecia Areata in Male Patients

9 citations , January 2019 in “American Journal of Dermatopathology”

DKK-1 gene linked to hair loss in AGA and AA patients; more research needed for potential therapy.

Ectodysplasin-A2 Induces Dickkopf 1 Expression in Human Balding Dermal Papilla Cells Overexpressing the Ectodysplasin A2 Receptor

research Ectodysplasin-A2 induces dickkopf 1 expression in human balding dermal papilla cells overexpressing the ectodysplasin A2 receptor

4 citations , July 2020 in “Biochemical and Biophysical Research Communications”

A protein called ectodysplasin-A2 increases a hair growth inhibitor in balding cells, which could be a target for hair loss treatment.

L-Ascorbic Acid 2-Phosphate Represses Dihydrotestosterone-Induced Dickkopf-1 Expression in Human Balding Dermal Papilla Cells

research I‐Ascorbic acid 2‐phosphate represses the dihydrotestosterone‐induced dickkopf‐1 expression in human balding dermal papilla cells

13 citations , November 2010 in “Experimental Dermatology”

Vitamin C derivative reduces hair loss-related protein in cells.

research Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosteroneinduced dickkopf-1 expression in human hair dermal papilla cells

31 citations , October 2010 in “BMB Reports”

L-threonate may help prevent balding by blocking a key protein.

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community Has anyone used Magnesium L-Threonate ?

70 upvotes 7 years ago

Magnesium L-Threonate may help treat balding by reducing DKK-1 expression without affecting DHT. Users discuss its potential effectiveness and application methods, with some considering trying it topically.

community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

in Research/Science 93 upvotes 4 years ago

The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

community A Theory on Why Microneedling Works

170 upvotes 6 years ago

Microneedling may enhance hair regrowth by transferring stem cells to dormant follicles, improving the effects of minoxidil. Users discuss using microneedling with needle lengths around 1.5mm to stimulate hair growth.

community Trialing the probiotics BB536, PTA 6475 so you don’t have to

in Research/Science 75 upvotes 1 year ago

Probiotics like L. reuteri ATCC PTA 6475 and B. longum BB536 may improve hair growth and density by reducing inflammation and reversing DHT damage. The user is trialing these probiotics personally, ordering them from the U.S. to Canada, and plans to continue if no adverse effects occur.

community Better Than Minoxidil? Topical Sodium Valproate

in Research/Science 50 upvotes 1 year ago

Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.

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