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GlossaryDNA fragmentation

breaking of DNA strands into smaller pieces

DNA fragmentation refers to the breaking of DNA strands into smaller pieces. This can occur naturally during processes like apoptosis (programmed cell death) or can be induced by external factors such as radiation or certain chemicals. In a clinical or research setting, measuring DNA fragmentation can be important for understanding cell health, diagnosing diseases, or assessing the quality of sperm in fertility studies.

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Research

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research Faculty Opinions recommendation of Tracking research trends and hotspots in sperm DNA fragmentation testing for the evaluation of male infertility: a scientometric analysis.

January 2020 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

More research is needed to make sperm DNA fragmentation a reliable tool for diagnosing male infertility.

research Tracking research trends and hotspots in sperm DNA fragmentation testing for the evaluation of male infertility: a scientometric analysis

48 citations , December 2019 in “Reproductive Biology and Endocrinology”

More research is needed to confirm sperm DNA fragmentation as a reliable tool for diagnosing male infertility.

research Finasteride-induced secondary infertility associated with sperm DNA damage

36 citations , February 2011 in “Fertility and Sterility”

Finasteride use may cause sperm damage and infertility, stopping it can improve sperm health.

research Apoptosis in human skin development: Morphogenesis, periderm, and stem cells

253 citations , March 1994 in “Developmental dynamics”

Apoptosis is essential for human skin development and forming a functional epidermis.

research Recent advances in understanding and managing male infertility

104 citations , May 2019 in “F1000Research”

Losing weight, fixing varicoceles, and using advanced sperm selection methods improve male infertility treatment outcomes.

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community IVF process on Finasteride and effects of stopping finasteride.

in Finasteride/Dutasteride 137 upvotes 7 months ago

Concerns about finasteride affecting sperm quality and embryo abnormalities during IVF. The user plans to stop finasteride for 6 months and use minoxidil, microneedling, a red light cap, and saw palmetto shampoo to manage hair loss.

community Haunting study is making me considering cycling fin/dut

in Research/Science 158 upvotes 1 year ago

Concerns about the long-term effects of dutasteride and finasteride on fertility, with discussions on cycling these medications to mitigate risks. The conversation highlights skepticism about study methodologies and the importance of weighing treatment risks against potential fertility issues.

community New warning by FDA on topical finasteride

in Research/Science 194 upvotes 1 year ago

The FDA warned that topical finasteride can cause serious side effects like sexual dysfunction and brain fog, similar to oral finasteride. Compounded topical formulations pose additional risks due to lack of regulation.

community Dutasteride Infertility Debunked: Low T causes true infertility.

in Finasteride/Dutasteride 167 upvotes 1 year ago

Dutasteride and finasteride may temporarily affect semen quality but are unlikely to cause permanent infertility. The Kim et al. study is criticized for poor methodology, and many prefer hair retention over potential fertility concerns, using treatments like dutasteride, finasteride, and minoxidil.

community Fresh off the press: Dutasteride may cause chronic infertility

in Research/Science 643 upvotes 1 year ago

Dutasteride may cause chronic infertility by reducing semen volume and motility, with concerns about irreversible prostate fibrosis. Users consider switching to finasteride or using treatments like minoxidil and microneedling, weighing hair preservation against fertility.

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learn sh-Polypeptide-7

learn Thymosin Beta 4

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