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5alpha-Reductase Inhibitors Dampen L-DOPA-Induced Dyskinesia via Normalization of Dopamine D1-Receptor Signaling Pathway and D1-D3 Receptor Interaction

research 5alpha-reductase inhibitors dampen L-DOPA-induced dyskinesia via normalization of dopamine D1-receptor signaling pathway and D1-D3 receptor interaction

26 citations , September 2018 in “Neurobiology of Disease”

Finasteride and dutasteride reduce unwanted movements from Parkinson's disease treatment by normalizing certain brain signals.

research Epigenetic Effects of Finasteride on Dopaminergic Signaling Pathways: A potential contributor to Post-Finasteride Syndrome

May 2024 in “Physiology”

Finasteride may cause changes in dopamine-related genes, possibly leading to post-finasteride syndrome.

research Inhibition of 5α-reductase in the nucleus accumbens counters sensorimotor gating deficits induced by dopaminergic activation

53 citations , October 2011 in “Psychoneuroendocrinology”

Finasteride may help improve certain brain function issues linked to dopamine.

research Regulation of itch-induced scratching by nucleus accumbens dopamine receptor-expressing neurons

April 2026 in “bioRxiv (Cold Spring Harbor Laboratory)”

Dopamine receptors in the brain influence itch-related scratching behavior.

research Androgens and Parkinson’s disease: the role in humans and in experiment

1 citations , September 2022 in “Problems of Endocrinology”

Dutasteride shows promise as a potential treatment for Parkinson's disease.

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community Taking finasteride turned me bicurious - a cautionary tale.

in Satire 623 upvotes 3 years ago

A user's experience taking finasteride, which resulted in them having an unexpected emotional reaction, and the replies to this post focus on the humorous aspects of cautionary tales about hair loss treatments.

community Why HMI115 should work if it doesn’t affect dht?

in Research/Science 16 upvotes 3 years ago

Hair growth can be induced without stopping DHT, as seen with Minoxidil. HMI115 may work by promoting follicle growth, not targeting the root cause of hair loss (DHT).

community Finasteride does deplete important nuero-active steroids

in Research/Science 10 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community Why does finasteride stop working?

in Finasteride/Dutasteride 26 upvotes 1 year ago

Finasteride may seem less effective over time due to increased DHT sensitivity or aging, but it still suppresses DHT. Switching to dutasteride offers stronger DHT suppression but may increase estrogen levels.

community DHT is NOT very important for adults, is it?

in Finasteride/Dutasteride 120 upvotes 3 months ago

A user experienced negative side effects, including low libido and lack of motivation, after using finasteride for hair loss and felt better after stopping it. Others shared similar experiences with finasteride and dutasteride, while some reported no side effects, showing varied individual responses.

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