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research MLL histone methylases in estrogen‐mediated regulation of HOX genes involved in hair follicle development and leukemia

3 citations , April 2010 in “The FASEB Journal”

Estrogen and MLL enzymes work together to regulate genes important for hair growth and leukemia.

research Decision letter: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage

June 2021

Different types of sun exposure can damage skin cells and affect healing, with chronic exposure being more harmful, and certain immune cells help in the repair process.

Androgen Receptor Activation Integrates Complex Transcriptional Effects in Osteoblasts, Involving the Growth Factors TGF-β and IGF-I, and Transcription Factor C/EBPδ

research Androgen receptor activation integrates complex transcriptional effects in osteoblasts, involving the growth factors TGF-β and IGF-I, and transcription factor C/EBPδ

11 citations , July 2015 in “Gene”

DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.

Identification of Transcriptional Targets of Wnt/β-Catenin Signaling in Dermal Papilla Cells of Human Scalp Hair Follicles: EP2 Is a Novel Transcriptional Target of Wnt3a

research Identification of transcriptional targets of Wnt/β-catenin signaling in dermal papilla cells of human scalp hair follicles: EP2 is a novel transcriptional target of Wnt3a

29 citations , March 2010 in “Journal of Dermatological Science”

Wnt3a activates certain genes in hair follicle cells, including a newly discovered one, EP2, which may affect hair growth.

research Polyamine Oxidase Expression Is Downregulated by 17β-Estradiol via Estrogen Receptor 2 in Human MCF-7 Breast Cancer Cells

8 citations , July 2022 in “International Journal of Molecular Sciences”

17β-estradiol lowers polyamine oxidase levels in breast cancer cells through estrogen receptor 2.

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community Getting bloods done whilst on finasteride

in General 98 upvotes 1 year ago

Finasteride can affect hormone levels within two weeks, and a break of several weeks is recommended for baseline results. Monitoring E2 and testosterone is suggested to assess the risk of gynecomastia.

community It's not fair I'm the one who's supposed to have the most hair.

in Satire 78 upvotes 11 months ago

People discussed hair loss treatments, including finasteride, minoxidil, and microneedling, with varying results and concerns about genetics and hormone levels. Some users shared personal experiences with medication dosages and side effects, while others mentioned the impact of stress on hair loss.

community How is it that golden era bodybuilders kept their hair while blasting gear while in the modern era most are bald? I’m convinced there’s something in our food and water causing MPB to speed up

in Satire 726 upvotes 2 years ago

The conversation is about the difference in hair loss between bodybuilders in the "Golden Era" and modern bodybuilders. Some users speculate that factors such as the types and doses of steroids used, genetics, diet, microplastics, and overall health may contribute to hair loss. Hair loss prevention medication and transplants are mentioned as potential treatments.

community What can be the real reason of Finasteride SE ?

in Finasteride/Dutasteride 19 upvotes 1 year ago

Finasteride can cause side effects like erectile dysfunction and decreased libido, possibly due to increased estradiol from testosterone aromatization, especially in those with higher body fat. Side effects vary widely and may also be influenced by genetic factors or neurosteroid inhibition.

community Estradiol blood test on fin. Doctor dont want to give me the test.

in Finasteride/Dutasteride 10 upvotes 2 years ago

The user has been taking 0.5 finasteride for 10 months and wants to repeat blood tests, including estradiol. However, their doctor is reluctant to test estradiol, arguing it's typically low in men, and the user is considering seeking a second opinion.

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