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This systematic review and meta-analysis evaluated the efficacy and safety of lasers and energy-based devices (EBDs) in treating androgenetic alopecia (AGA), involving 3,298 patients across 37 studies. Low-level light therapy (LLLT) increased hair density by 18.56 hairs/cm² and shaft thickness by 10.62 µm compared to sham treatments. Fractional laser monotherapy showed a more substantial increase in density (102.23 hairs/cm²) and a moderate increase in thickness (5.93 µm). Combination protocols with fractional lasers and agents like minoxidil, PRP, or growth factors resulted in even greater improvements in hair density (+33.6 hairs/cm²) and thickness (+11.22 µm), with global photographic improvement rates of 77.2% for monotherapy and 95.3% for combination treatments. Adverse events were mild and transient, indicating that LLLT and fractional lasers are effective and safe for AGA, especially when combined with other treatments.

This systematic review and meta-analysis evaluated the efficacy and safety of lasers and energy-based devices (EBDs) in treating androgenetic alopecia (AGA), involving 3,298 patients across 37 studies. Low-level light therapy (LLLT) showed a mean increase in hair density of 18.56 hairs/cm² and shaft thickness of 10.62 µm compared to sham treatments. Fractional laser monotherapy increased hair density by 102.23 hairs/cm² and thickness by 5.93 µm, while combination protocols with minoxidil, PRP, or growth factors further improved density by 33.6 hairs/cm² and thickness by 11.22 µm. Global photographic improvement rates were 77.2% for fractional laser monotherapy and 95.3% for combination protocols. Adverse events were mild and transient, indicating that LLLT and fractional lasers are effective and safe for AGA, especially when combined with other treatments.