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GlossaryEnzymatic Digestion

Enzymatic digestion refers to the biochemical process in which enzymes break down complex molecules into simpler forms, facilitating nutrient absorption and metabolism. In the context of hair biology, enzymatic digestion can influence the degradation of hair follicle components and extracellular matrix proteins, which may play a role in hair loss conditions such as androgenetic alopecia. Key distinguishing characteristics include the specificity of enzymes for particular substrates and the role of this process in maintaining healthy hair follicle function and overall scalp health.

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research Impact of the Different Preparation Methods to Obtain Human Adipose-Derived Stromal Vascular Fraction Cells (AD-SVFs) and Human Adipose-Derived Mesenchymal Stem Cells (AD-MSCs): Enzymatic Digestion Versus Mechanical Centrifugation

124 citations , November 2019 in “International Journal of Molecular Sciences”

Standardized kits improve the quality and consistency of isolating stem cells from fat tissue.

research Bulge-Derived Epithelial Cells Isolated from Human Hair Follicles Using Enzymatic Digestion or Explants Result in Comparable Tissue-Engineered Skin

1 citations , February 2025 in “International Journal of Molecular Sciences”

Enzymatic digestion is an efficient method for isolating cells from hair follicles for tissue-engineered skin.

Enzymatic Digestion of Scalp Hair Follicle Bulge Yields More Stem Keratinocytes Than Explant Isolation

research 1435 Enzymatic digestion of scalp hair follicle bulge allows to have more bulge-derived stem keratinocytes than explant isolation

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Using enzymes to break down scalp hair follicles gets more stem cells for skin and hair growth than the old method.

research Bioactive peptides derived from food proteins preventing lifestyle‐related diseases

223 citations , January 2000 in “BioFactors”

Food-derived peptides may help prevent diseases like high blood pressure and high cholesterol, and can support the immune system.

Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma, and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects

research Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects

70 citations , February 2021 in “International Journal of Molecular Sciences”

Fat-derived stem cells, platelet-rich plasma, and biomaterials show promise for healing chronic skin wounds and improving soft tissue with few side effects.

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community The theory that explains everything - First Evidence of Hair regrow attributed to upregulating 3aHSD

in Treatment 174 upvotes 5 years ago

Hair regrowth treatment involving 3aHSD enzyme shows 6% improvement in 18 weeks. Sulforaphane, L-Menthol, and Dexpanthenol are potential ingredients for new hair loss solution.

community The theory that explains everything. Please help me make this big!

in Research/Science 2446 upvotes 5 years ago

The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 2 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community Creatine is the opposite of minoxidil !

in Research/Science 315 upvotes 9 months ago

Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

community Quit vaping/smoking = 80% less loss

in Research/Science 235 upvotes 2 years ago

Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

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