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research Shushing down the epigenetic landscape towards stem cell differentiation
The document concludes that pig iPSCs show promise for transplant therapies and the field is advancing in controlling cell behavior for biology and medicine.
research Single-cell chromatin landscapes of mouse skin development
The study maps how genes are regulated during mouse hair growth.
research 1431 Skin aging and hair follicle stem cell dysfunction caused by T cells with defective mitochondrial metabolism
Defective T cell metabolism can cause early skin aging and poor hair follicle stem cell function.
research 768 Dermal fibroblast expression of lef1 is critical to normal skin and hair development and regenerative wound healing in mice
Lef1 is essential for normal skin, hair growth, and healing wounds in mice.
research Transcriptional and epigenetic mechanisms governing epidermal stem cell regulation
This review examines the transcriptional and epigenetic mechanisms that regulate epidermal and hair follicle stem cells, crucial for skin maintenance and regeneration. It highlights the roles of transcription factors like p63, YAP, TCF3, SOX9, and LHX2, and epigenetic regulators such as polycomb repressive complexes and histone modifiers in maintaining stem cell identity and function. The review underscores the importance of these mechanisms in balancing stem cell self-renewal and differentiation, with disruptions leading to skin diseases like basal cell carcinoma, psoriasis, and hidradenitis suppurativa. It also discusses the plasticity of hair follicle stem cells in aiding epidermal regeneration and the potential of single-cell technologies to uncover stem cell heterogeneity and chromatin landscapes. Understanding these regulatory networks is vital for developing therapeutic strategies for skin disorders.
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5 / 1000+ resultscommunity A Summary of the Latest Research regarding PFS, and How Supplementing Allopregnanolone Might Protect Against It
Post Finasteride Syndrome (PFS) may result from epigenetic changes and gut microbiota alterations. Supplementing with Allopregnanolone might protect against these adverse effects.
community Any MD/DO’s in this subreddit?
The conversation discusses hair loss treatments, specifically Minoxidil, finasteride, and RU58841. The user seeks input from medical professionals and scientists on these treatments.
community Hey so i started using rogaine 5% Minoxidil 2 times a day and i micro needle and use nizoral shampoo
The user has been using 5% Minoxidil twice daily, microneedling, and Nizoral shampoo for three months with noticeable progress. They are considering adding finasteride but currently take saw palmetto due to concerns about side effects.
community It's not just about your hair, it's also about YOU!
The user has been on Finasteride and oral Minoxidil for hair loss and experienced minimal side effects. They suggest that a healthy lifestyle, including good sleep, exercise, diet, skincare, and mental health care, may help reduce the perceived side effects of Finasteride, although another user disagrees, emphasizing that side effects can vary and may not be mitigated by lifestyle alone.
community Why dont we research more on body hair
Body hair is more resilient than scalp hair due to different gene expressions and DHT sensitivity. Treatments like minoxidil and finasteride are used for hair loss, but they have varying effects on body and scalp hair.