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GlossaryEpithelial Stem Cells

cells that regenerate and repair skin and hair follicles

Epithelial Stem Cells are a type of stem cell found in the epithelial tissues, which line the surfaces and cavities of organs and structures throughout the body, including the skin and hair follicles. These cells have the unique ability to self-renew and differentiate into various specialized cell types, playing a crucial role in tissue repair, regeneration, and maintaining the integrity of the epithelial layers.

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Research

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research Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche

220 citations , June 2013 in “The Journal of Pathology”

Lichen planopilaris may be an autoimmune disease causing hair loss due to immune system issues in hair follicles.

research Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices

214 citations , April 2017 in “Cell”

Different small areas within hair follicles send specific signals that control what type of cells stem cells become.

research 09-P006 Epithelial–mesenchymal interactions promote hair follicle neogenesis and a new stem cell niche in adult corneal epithelium

August 2009 in “Mechanisms of Development”

Adult hair follicle cells can create new hair follicles from corneal cells with the right support.

research The Epithelial Stem Cell Niche in Skin

9 citations , January 2017 in “Elsevier eBooks”

Skin's epithelial stem cells are crucial for repair and maintenance, and understanding them could improve treatments for skin problems.

research Tooth, hair and claw: Comparing epithelial stem cell niches of ectodermal appendages

14 citations , February 2014 in “Experimental Cell Research”

The conclusion is that teeth, hair, and claws have similar stem cell niches, which are important for growth and repair, and more research is needed on their regulation and potential markers.

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community Researchers working on ways to regenerate lost hair from stem cells identified a recipe for normal hair regeneration in the lab. “A method for cyclical regeneration of hair follicles from hair follicle stem cells and will help make hair follicle regeneration therapy a reality in the near future.”

in Research/Science 263 upvotes 5 years ago

Hair loss treatments like finasteride, minoxidil, and hair transplants have side effects and limitations. There is hope for future advancements in stem cell therapy and hair follicle regeneration, though skepticism about their effectiveness and timeline persists.

community DHT Isn’t the Only Factor in Hair Loss and That Might Be the Key to a Real Cure

in Research/Science 372 upvotes 5 months ago

Hair loss involves more than just DHT, with genetic factors like TRPS affecting hair follicles. Treatments such as Amplifica's AMP-601 and AMP-303 target stem cells for potential hair growth solutions.

community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

in Research/Science 59 upvotes 4 months ago

Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 443 upvotes 5 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 4 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

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