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Research

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research [Epididymis in an experimental model of DHT deficiency: immunolocalization of ERalpha and ERbeta in rat epididymal epithelial cells. In vivo and in vitro studies].

4 citations , January 2006 in “PubMed”

DHT deficiency may disrupt rat epididymis function by affecting estrogen receptors.

research 202 Activation of breast cancer cell proliferation by ROR-alpha through aromatase promoter

March 2010 in “Ejc Supplements”

ROR-alpha may increase the growth of certain breast cancer cells by boosting aromatase, which could affect breast cancer prognosis.

research Hair Cycle Control by Estrogens: Catagen Induction via Estrogen Receptor (ER)-α Is Checked by ERβ Signaling

92 citations , February 2005 in “Endocrinology”

Estrogen receptors affect hair growth, with ER beta slowing down the hair cycle changes caused by ER alpha.

research The Modulation of Aromatase and Estrogen Receptor Alpha in Cultured Human Dermal Papilla Cells by Dexamethasone: A Novel Mechanism for Selective Action of Estrogen via Estrogen Receptor Beta?

65 citations , May 2006 in “Journal of Investigative Dermatology”

Dexamethasone may influence hair growth by altering estrogen receptor activity in hair cells.

research Ferulic acid promotes hair growth via estrogen receptor alpha activation in cultured human dermal papilla cells

March 2026 in “Scientific Reports”

Ferulic acid may help hair grow by activating certain receptors in cells.

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Clinics

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Community Join

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community Mechanism of action of alfatradiol (17 alpha estradiol)

in Research/Science 5 upvotes 2 years ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community Update: Chest discomfort from RU58841

in Update 35 upvotes 2 years ago

A user experienced severe chest pains and shortness of breath after using RU58841 for hair loss and was advised by a doctor that blocking androgens can weaken the heart. They decided to continue with finasteride, minoxidil, and a hair transplant instead.

community Vitamin E

18 upvotes 7 years ago

Vitamin E was discussed as a treatment for hair shedding, with a specific form mentioned. A user shared a link to a study and started taking the Vitamin E variants used.

community 5 Months on topical Fin/Min progress: grows hair and boobs

in Progress Pictures 159 upvotes 9 months ago

The user experienced significant hair growth using topical finasteride and minoxidil but noticed nipple changes, suggesting early gynecomastia. They plan to stop the treatment and consider blood work to check hormonal balance.

community Dutasteride takes 1-3 months to work in the scalp. Not weeks. Be careful.

in Finasteride/Dutasteride 41 upvotes 1 year ago

Dutasteride takes 1-3 months to affect scalp DHT levels, not just a week. The prostate absorbs Dutasteride faster than the scalp due to different vascular networks and enzyme densities.

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Experts

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