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5 / 1000+ resultsresearch XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss
The study explores the role of DDRGK1-mediated ER-phagy in noise-induced hearing loss (NIHL), revealing that ER-phagy is crucial for maintaining ER homeostasis and cell survival. It was found that noise exposure decreases XIAP and DDRGK1 protein levels, inhibiting ER-phagy. XIAP binds to DDRGK1, enhancing its stability and activating ER-phagy. In noise-exposed CBA/CaJ mice, gastrodin, a traditional Chinese medicine ingredient, mitigates cochlear hair cell loss, synaptic damage, and hearing loss by promoting XIAP expression, which increases DDRGK1 levels and activates ER-phagy. These results suggest that targeting XIAP-DDRGK1-mediated ER-phagy could be a novel therapeutic approach for treating NIHL.
research Calreticulin: non‐endoplasmic reticulum functions in physiology and disease
Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.
research The Hair Follicle as an Estrogen Target and Source
Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.
research Pharmacological activation of estrogen receptors-α and -β differentially modulates keratinocyte differentiation with functional impact on wound healing
Activating ER-β, not ER-α, improves skin cell growth and wound healing.
research Development of phage-containing hydrogel for treating Enterococcus faecalis-infected wounds
Phage-containing hydrogels effectively heal wounds infected with Enterococcus faecalis.
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5 / 1000+ resultscommunity I ended up in the ER due to oral Minoxodil.
A user experienced severe side effects, including heart issues, after taking oral minoxidil without consulting a doctor. They are now considering alternatives like dutasteride, PRP, or laser treatments for hair loss.
community Oral Minoxidil- Be Careful!!!!!
Oral minoxidil can cause severe side effects, including heart issues, even at low doses. Users suggest starting with a lower dose or using topical treatments to minimize risks.
community Extreme caution: my experience using Ru58841 only once
An 18-year-old experienced severe side effects, including heart palpitations and high blood pressure, after using RU58841 once, leading to a referral to cardiology for suspected left ventricular hypertrophy. The user regrets using RU58841 and seeks advice on recovery, while others suggest preexisting conditions or genetic predispositions may be factors.
community I don’t get Finasteride prescribed anymore..
Finasteride is expensive in Germany, but cheaper alternatives are available in other countries like Turkey, Greece, and Russia. Users suggest traveling to these countries or seeking online prescriptions to save money.
community 2 months in, I think it's working
The user reported positive progress in hair regrowth after two months using finasteride, topical minoxidil, microneedling, and ketoconazole, later switching to dutasteride. Some users doubted the authenticity of the results, while others were impressed and encouraged by the progress.