Search
for

    GlossaryProgerin

    defective protein causing premature aging in Hutchinson-Gilford Progeria Syndrome

    Progerin is a defective protein that is produced in cells due to a mutation in the LMNA gene, which normally codes for the lamin A protein. This abnormal protein is associated with Hutchinson-Gilford Progeria Syndrome (HGPS), a rare genetic disorder that causes accelerated aging in children. Progerin disrupts the normal structure and function of the cell nucleus, leading to various symptoms of premature aging.

    Related Terms

    Sort by

    Clinics