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Tumor Necrosis Factor Alpha, Interferon Gamma, and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin

research Tumour Necrosis Factor Alpha, Interferon Gamma and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin

24 citations , April 2013 in “PLOS ONE”

TNFα, IFNγ, and Substance P significantly affect prolactin levels in human skin, suggesting new treatments for skin and hair conditions.

research Utilizing the hair follicle to dissect the regulation and autocrine/paracrine activities of prolactin in humans

12 citations , May 2012 in “Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism”

Human scalp hair follicles can be used to study how prolactin affects hair growth and cell death.

research Prolactin and the Skin: A Dermatological Perspective on an Ancient Pleiotropic Peptide Hormone

98 citations , December 2008 in “Journal of Investigative Dermatology”

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

research Prolactin: an emerging force along the cutaneous–endocrine axis

51 citations , July 2010 in “Trends in Endocrinology and Metabolism”

Prolactin may play a significant role in skin and hair health and could be a target for treating skin and hair disorders.

Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression

research Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression

128 citations , March 2006 in “American Journal of Pathology”

Prolactin contributes to hair loss by promoting hair follicle shrinkage and cell death.

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community A New Hair Loss Drug Could Cure Balding and Reverse Graying

in Research/Science 368 upvotes 9 months ago

ABS-201, a prolactin receptor blocker, shows promise in reversing hair loss and graying, with early success in macaques. Current treatments like finasteride, minoxidil, and RU58841 are still widely used, but new options like PP405 are eagerly anticipated.

community Why HMI115 should work if it doesn’t affect dht?

in Research/Science 16 upvotes 3 years ago

Hair growth can be induced without stopping DHT, as seen with Minoxidil. HMI115 may work by promoting follicle growth, not targeting the root cause of hair loss (DHT).

community Further prolactin research....

in Research/Science 6 upvotes 2 years ago

HMI 115 did not work as expected for hair regrowth in humans, unlike in macaque monkeys. There is anticipation for further research on prolactin's role in hair loss, with expectations that pharmaceutical companies will likely solve this before universities.

community Whats up with Prolactine these days?

in Research/Science 20 upvotes 3 years ago

The conversation discusses the potential role of prolactin in hair loss and mentions treatments like HMI115, mucuna pruriens, Zinc, and B6 P5P for lowering prolactin levels. It also touches on the use of natural compounds and the lack of studies due to funding issues.

community If inhibiting DHT can cause Prolactin to increase then is the opposite also true?

in Treatment 5 upvotes 2 years ago

The conversation discusses using P5P (Vitamin B6) supplements to reduce elevated Prolactin levels and concerns about its potential effect on increasing DHT levels. The user is not currently using finasteride or any anti-androgens.

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learn HMI-115

much-hyped research compound targeting prolactin receptor in scalp

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