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GlossaryFatigue

state of physical or mental weariness from exertion or stress

Fatigue, also known as tiredness or exhaustion, is a state of physical and/or mental weariness that can result from prolonged exertion, lack of sleep, stress, or underlying medical conditions. It is characterized by a reduced capacity for work and efficiency of accomplishment, often accompanied by a feeling of lethargy and a lack of motivation. In a clinical context, fatigue can be a symptom of various health issues, including anemia, chronic fatigue syndrome, and depression.

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Research

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Fatigue, Alopecia, and Stomatitis Among Patients With Breast Cancer Receiving Cyclin-Dependent Kinase 4 and 6 Inhibitors: A Systematic Review and Meta-Analysis

research Fatigue, alopecia and stomatitis among patients with breast cancer receiving cyclin-dependent kinase 4 and 6 inhibitors: a systematic review and meta-analysis

28 citations , July 2017 in “Expert Review of Anticancer Therapy”

Breast cancer patients taking CDK4/6 inhibitors are more likely to experience fatigue, hair loss, and mouth sores.

research Transitional Changes in Fatigue-Related Symptoms Due to Long COVID: A Single-Center Retrospective Observational Study in Japan

8 citations , October 2022 in “Medicina-lithuania”

Patients with long COVID after Omicron had fewer hospitalizations and milder symptoms but more fatigue, insomnia, and cough compared to those with Delta.

research Beyond Perceived Stress: Hair Cortisol is linked with Cognition and Fatigue in Black and White Patients with Multiple Sclerosis

June 2026 in “Psychoneuroendocrinology”

Higher cortisol levels and stress are linked to worse cognition and more fatigue in MS patients.

research Increased risk of chronic fatigue and hair loss following COVID-19 in individuals with hypohidrotic ectodermal dysplasia

2 citations , September 2021 in “Orphanet Journal of Rare Diseases”

People with hypohidrotic ectodermal dysplasia are more likely to experience long-term fatigue and hair loss after COVID-19.

Qualitative Patient Interview Study in Patients with Systemic Lupus Erythematosus to Assess Patient Perception of Fatigue and Skin-Related Symptoms

research QUALITATIVE PATIENT INTERVIEW STUDY IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS TO ASSESS PATIENT PERCEPTION OF FATIGUE AND SKIN-RELATED SYMPTOMS

May 2025 in “The Journal of Rheumatology”

People with lupus find fatigue and skin issues very bothersome, and even small improvements are meaningful.

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Community Join

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community Experiencing Anxiety and Fatigue After 1 Week on Finasteride – Looking for Advice

in Finasteride 74 upvotes 7 months ago

The user experienced anxiety, dizziness, and fatigue after starting finasteride and is seeking advice on whether to continue, adjust the dose, or consult a doctor. They stopped taking finasteride and are unsure if it caused their symptoms.

community Experiencing Dizziness, Heart Thumping, and Fatigue on 0.625mg Oral Minoxidil After 5 Days - Should I Continue?

in Basic Questions 46 upvotes 4 months ago

Oral minoxidil at 0.625mg/day caused dizziness, heart thumping, and fatigue. The user is concerned if these side effects will subside or indicate unsuitability for the medication.

community Finally decided to buzz my head after experiencing hair loss since I was 17 (23 now). I think it looks decent, swipe to see what I was rocking before during the pandemic. Who knows maybe I’ll hop on fin but as someone who struggles with chronic fatigue and low test I’m hesitant.

in Shaved/buzzed 326 upvotes 3 years ago

A user's decision to shave their head after experiencing hair loss since the age of 17, and discussion around the potential use of Fin for treating hair loss.

community Can I switch from Min to Nanoxidil?

in Minoxidil 1 upvotes 1 year ago

The user is considering switching from Minoxidil to Nanoxidil due to severe fatigue while continuing with Topical Finasteride and oral Dutasteride. They hope to maintain hair gains without the side effects of Minoxidil.

community What are the 'safer' alternatives to RU58841?

in Research/Science 2 upvotes 2 years ago

A user discusses switching from RU58841 to Pyrilutamide due to side effects like fatigue, brain fog, and elevated heart rate. They have used dutasteride, finasteride, and minoxidil, and are seeking safer alternatives.

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